PMID- 36203711
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231002
IS  - 1793-9453 (Electronic)
IS  - 1793-8759 (Print)
IS  - 1793-9453 (Linking)
VI  - 14
IP  - 4
DP  - 2022 Oct
TI  - Conception of Saviour Siblings: Religious Views in Malaysia.
PG  - 363-377
LID - 10.1007/s41649-022-00216-3 [doi]
AB  - The advancement of human reproductive technology has made it possible for parents 
      with a child affected by a haematological disorder to select and bring into 
      being, a prospective child who can act as a matched stem cell donor. This can be 
      done through the use of preimplantation genetic diagnosis (PGD) coupled with 
      human leukocyte antigen (HLA) typing (PGD-HLA typing), or HLA tying as a 
      standalone procedure, where a healthy embryo, which is an HLA match to the 
      existing sick sibling, is chosen for implantation. The creation of such a sibling 
      (saviour sibling) is normally taken as a last resort when there is no related or 
      unrelated matched donor. While the conception of a saviour sibling may serve as a 
      reliable and realistic treatment option for the ailing child, it also poses new 
      moral questions that challenge a religiously pluralistic society such as 
      Malaysia. The use of PGD-HLA typing may be controversial as it involves creating 
      a life to save a life, selection of compatible human embryos and destruction of 
      the unselected embryos. At present, there is no legal framework regulating the 
      conception of saviour siblings. The development of ethically sound and 
      appropriate local laws and policies should consider the views of religious 
      communities, especially when it involves a controversial subject such as the 
      conception of saviour siblings. This article seeks to explore the perceptions of 
      religious scholars and representatives of the major religions professed and 
      practised in Malaysia, namely Islam, Buddhism, Christianity and Hinduism, through 
      qualitative interviews.
CI  - (c) National University of Singapore and Springer Nature Singapore Pte Ltd. 2022, 
      Springer Nature or its licensor holds exclusive rights to this article under a 
      publishing agreement with the author(s) or other rightsholder(s); author 
      self-archiving of the accepted manuscript version of this article is solely 
      governed by the terms of such publishing agreement and applicable law.
FAU - Kuek, Chee Ying
AU  - Kuek CY
AUID- ORCID: 0000-0001-5545-2846
AD  - Faculty of Law, Multimedia University, Melaka, Malaysia. GRID: grid.411865.f. 
      ISNI: 0000 0000 8610 6308
FAU - A/P Gurmukh Singh, Sharon Kaur
AU  - A/P Gurmukh Singh SK
AUID- ORCID: 0000-0001-7809-3292
AD  - Faculty of Law, University of Malaya, Kuala Lumpur, Malaysia. GRID: 
      grid.10347.31. ISNI: 0000 0001 2308 5949
LA  - eng
PT  - Journal Article
DEP - 20220903
PL  - England
TA  - Asian Bioeth Rev
JT  - Asian bioethics review
JID - 101608807
PMC - PMC9530092
OTO - NOTNLM
OT  - HLA typing
OT  - Haematopoietic stem cell transplantation
OT  - Preimplantation genetic diagnosis
OT  - Religion
OT  - Reproductive Ethics
OT  - Saviour sibling
COIS- Conflict of InterestThe authors declare no competing interests.
EDAT- 2022/10/08 06:00
MHDA- 2022/10/08 06:01
PMCR- 2023/10/01
CRDT- 2022/10/07 02:39
PHST- 2022/05/14 00:00 [received]
PHST- 2022/08/12 00:00 [revised]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2022/10/07 02:39 [entrez]
PHST- 2022/10/08 06:00 [pubmed]
PHST- 2022/10/08 06:01 [medline]
PHST- 2023/10/01 00:00 [pmc-release]
AID - 216 [pii]
AID - 10.1007/s41649-022-00216-3 [doi]
PST - epublish
SO  - Asian Bioeth Rev. 2022 Sep 3;14(4):363-377. doi: 10.1007/s41649-022-00216-3. 
      eCollection 2022 Oct.