PMID- 36204135
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221009
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 15
DP  - 2022
TI  - Corticotropin-releasing factor system in the lateral septum: Implications in the 
      pathophysiology of obesity.
PG  - 1020903
LID - 10.3389/fnmol.2022.1020903 [doi]
LID - 1020903
AB  - Obesity is a pandemic associated with lifestyles changes. These include excess 
      intake of obesogenic foods and decreased physical activity. Brain areas, like the 
      lateral hypothalamus (LH), ventral tegmental area (VTA), and nucleus accumbens 
      (NAcc) have been linked in both homeostatic and hedonic control of feeding in 
      experimental models of diet-induced obesity. Interestingly, these control systems 
      are regulated by the lateral septum (LS), a relay of gamma-aminobutyric (GABA) acid 
      neurons (GABAergic neurons) that inhibit the LH and GABAergic interneurons of the 
      VTA. Furthermore, the LS has a diverse receptor population for neurotransmitters 
      and neuropeptides such as dopamine, glutamate, GABA and corticotropin-releasing 
      factor (CRF), among others. Particularly, CRF a key player in the stress 
      response, has been related to the development of overweight and obesity. 
      Moreover, evidence shows that LS neurons neurophysiologically regulate reward and 
      stress, although there is little evidence of LS taking part in homeostatic and 
      hedonic feeding. In this review, we discuss the evidence that supports the role 
      of LS and CRF on feeding, and how alterations in this system contribute to weight 
      gain obesity.
CI  - Copyright (c) 2022 Olivares-Barraza, Marcos, Martinez-Pinto, Fuenzalida, Bravo, 
      Gysling and Sotomayor-Zarate.
FAU - Olivares-Barraza, Rossy
AU  - Olivares-Barraza R
AD  - Facultad de Ciencias, Centro de Neurobiologia y Fisiopatologia Integrativa 
      (CENFI), Instituto de Fisiologia, Universidad de Valparaiso, Valparaiso, Chile.
AD  - Programa de Doctorado en Ciencias Mencion Neurociencias, Universidad de 
      Valparaiso, Valparaiso, Chile.
FAU - Marcos, Jose Luis
AU  - Marcos JL
AD  - Facultad de Ciencias, Centro de Neurobiologia y Fisiopatologia Integrativa 
      (CENFI), Instituto de Fisiologia, Universidad de Valparaiso, Valparaiso, Chile.
AD  - Programa de Doctorado en Ciencias e Ingenieria para la Salud, Universidad de 
      Valparaiso, Valparaiso, Chile.
AD  - Escuela de Ciencias Agricolas y Veterinarias, Universidad Vina del Mar, Vina del 
      Mar, Chile.
FAU - Martinez-Pinto, Jonathan
AU  - Martinez-Pinto J
AD  - Facultad de Ciencias, Centro de Neurobiologia y Fisiopatologia Integrativa 
      (CENFI), Instituto de Fisiologia, Universidad de Valparaiso, Valparaiso, Chile.
FAU - Fuenzalida, Marco
AU  - Fuenzalida M
AD  - Facultad de Ciencias, Centro de Neurobiologia y Fisiopatologia Integrativa 
      (CENFI), Instituto de Fisiologia, Universidad de Valparaiso, Valparaiso, Chile.
FAU - Bravo, Javier A
AU  - Bravo JA
AD  - Facultad de Ciencias, Grupo de NeuroGastroBioquimica, Instituto de Quimica, 
      Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile.
FAU - Gysling, Katia
AU  - Gysling K
AD  - Facultad de Ciencias Biologicas, Departmento de Biologia Celular y Molecular, 
      Pontificia Universidad Catolica de Chile, Santiago, Chile.
FAU - Sotomayor-Zarate, Ramon
AU  - Sotomayor-Zarate R
AD  - Facultad de Ciencias, Centro de Neurobiologia y Fisiopatologia Integrativa 
      (CENFI), Instituto de Fisiologia, Universidad de Valparaiso, Valparaiso, Chile.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220920
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC9530601
OTO - NOTNLM
OT  - CRF system
OT  - addiction
OT  - feeding control
OT  - lateral septum (LS)
OT  - obesity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/08 06:00
MHDA- 2022/10/08 06:01
PMCR- 2022/01/01
CRDT- 2022/10/07 02:47
PHST- 2022/08/16 00:00 [received]
PHST- 2022/09/05 00:00 [accepted]
PHST- 2022/10/07 02:47 [entrez]
PHST- 2022/10/08 06:00 [pubmed]
PHST- 2022/10/08 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2022.1020903 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2022 Sep 20;15:1020903. doi: 10.3389/fnmol.2022.1020903. 
      eCollection 2022.