PMID- 36204175
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221009
IS  - 2158-8333 (Print)
IS  - 2158-8341 (Electronic)
IS  - 2158-8333 (Linking)
VI  - 19
IP  - 7-9
DP  - 2022 Jul-Sep
TI  - Abnormality of Contingent Negative Variation Correlates with Parkinson's Disease 
      Severity.
PG  - 71-76
AB  - OBJECTIVE: We sought to assess the influence of Parkinson's disease (PD) on 
      contingent negative variation (CNV). PATIENTS AND METHODS: This prospective study 
      included 49 patients with PD (69.7+/-16.5; 35 male) and 35 age- and sex-matched 
      controls. The PD cohort was subdivided, according to the Hoehn-Yahr Scale, 
      Unified Parkinson's Disease Rating Scale (UPDRS), and UPDRS Part III, into 30 
      cases of uncomplicated PD and 19 cases of advanced PD. CNV was recorded over the 
      frontal and central vertex with a linked bimastoid reference using a 
      dual-stimulus paradigm with interstimulus intervals (ISIs) of 1.7 and 2.0 
      seconds. RESULTS: In advanced PD, the amplitude of the late CNV over the central 
      vertex was markedly reduced (p<0.005) at ISI of 1.7 seconds and correlated 
      negatively with UPDRS (r=-0.32; p<0.003) and motor score (UPDRS Part III) 
      (r=-0.45; p<0.002). CONCLUSION: Late CNV amplitude was significantly abnormal in 
      PD and correlated with the severity of the motor manifestations.
CI  - Copyright (c) 2022. Matrix Medical Communications. All rights reserved.
FAU - Tzvetanov, Plamen
AU  - Tzvetanov P
AD  - Prof. Tzvetanov is with the Department of Clinical Neurophysiology, Broomfield 
      Hospital Mid Essex Hospital Trust in Broomfield, United Kingdom.
FAU - Lisichkov, Ivan
AU  - Lisichkov I
AD  - Dr. Lisichkov is with the Department of Neurology, Multiprofile Hospital for 
      Active Treatment of Russe in Ruse, Bulgaria.
FAU - Rousseff, Rossen T
AU  - Rousseff RT
AD  - Dr. Rousseff is with the Medical University of Pleven, Bulgaria.
FAU - Hegde, Vishwajit
AU  - Hegde V
AD  - Dr. Hegde is a Consultant Neurologisy and Neurophysiologist, University Hospitals 
      of Coventry and Warwickshire in Conventry, United Kingdom.
FAU - Kostadinov, Sergey
AU  - Kostadinov S
AD  - Dr. Kostadinov is an Assistant Professor, Department of General Medicine, 
      Forensic Medicine and Deontology, Faculty of Public Health, Medical University in 
      Pleven, Bulgaria.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Innov Clin Neurosci
JT  - Innovations in clinical neuroscience
JID - 101549695
PMC - PMC9507138
OTO - NOTNLM
OT  - CNV
OT  - Parkinson's disease
OT  - slow cortical potentials
COIS- DISCLOSURES: The authors have no conflicts of interest relevant to the contents 
      of this article.
EDAT- 2022/10/08 06:00
MHDA- 2022/10/08 06:01
PMCR- 2022/07/01
CRDT- 2022/10/07 02:48
PHST- 2022/10/07 02:48 [entrez]
PHST- 2022/10/08 06:00 [pubmed]
PHST- 2022/10/08 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
PST - ppublish
SO  - Innov Clin Neurosci. 2022 Jul-Sep;19(7-9):71-76.