PMID- 36205586
OWN - NLM
STAT- MEDLINE
DCOM- 20221215
LR  - 20221215
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 36
IP  - 12
DP  - 2022 Dec
TI  - The effects of curcumin-containing supplements on inflammatory biomarkers in 
      hemodialysis patients: A systematic review and meta-analysis.
PG  - 4361-4370
LID - 10.1002/ptr.7642 [doi]
AB  - In the past decade, the effect of curcumin or turmeric supplementation on many 
      aspects of health status in different populations has been evaluated. In the 
      present study, a systematic review and meta-analysis were conducted to estimate 
      the effect of curcumin administration on inflammatory markers in hemodialysis 
      (HD) patients. A systematic search was performed in MEDLINE, EMBASE, Scopus, and 
      Clarivate Analytics Web of Science databases from 1997 until June2022 for terms 
      related to curcumin/turmeric and hemodialysis (HD). Randomized, 
      double-blind/single-blind studies examining the effects of curcumin/turmeric on 
      the inflammation of HD participants older than 18 years were considered eligible 
      for inclusion. Data were pooled using the weighted mean difference (WMD) and 95% 
      CI as the summary statistic, considering a random-effects analysis model. The 
      data that were pooled from nine studies with 472 patients indicated that 
      curcumin-containing supplement had significant effect on serum C-reactive protein 
      (CRP) levels (WMD = -3.3 mg/L; 95% CI: -5.4 to -1.3; p < 0.001, I(2)  = 76.7%, 8 
      studies, 467 participants), and interlukine-6 (IL-6) levels (SMD: -0.4; 95% CI: 
      -0.8 to -0.07; p = 0.02, I(2)  = 31.6%, 3 studies, 153 participants) compared 
      control group. Although curcumin intervention could not change tumor neurosis 
      factor-alpha (TNF-alpha) concentration (SMD = -0.3; 95% CI: -0.7 to 0.04; p = 0.08, I(2) 
       = 25.3%, 3 studies, 153 participants), when compared with the placebo group. Our 
      study's main limitations were small number of studies, overall high risk of bias 
      in the included trials, and high heterogeneity in some results. The present 
      meta-analysis suggested that intervention with curcumin-containing supplements 
      was associated with a significant reduction in serum hs-CRP and IL-6 
      concentrations in HD patients. The curcumin intervention in the reduction of 
      hs-CRP levels was greater than the minimal clinically important difference (MCID) 
      for CRP (0.5 mg/L), which can be helpful in physicians' clinical decisions.
CI  - (c) 2022 John Wiley & Sons Ltd.
FAU - Arabi, Seyyed Mostafa
AU  - Arabi SM
AD  - Noncommunicable Diseases Research Center, Neyshabur University of Medical 
      Sciences, Neyshabur, Iran.
AD  - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Bahari, Hossein
AU  - Bahari H
AD  - Metabolic Syndrome Research Center, Department of Nutrition, School of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Hamidipor, Sina
AU  - Hamidipor S
AD  - Department of Physical Education & Sport Sciences, Mashhad Branch, Islamic Azad 
      University, Mashhad, Iran.
FAU - Bahrami, Leila Sadat
AU  - Bahrami LS
AD  - Noncommunicable Diseases Research Center, Neyshabur University of Medical 
      Sciences, Neyshabur, Iran.
AD  - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Feizy, Zahra
AU  - Feizy Z
AD  - Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA.
FAU - Nematy, Mohsen
AU  - Nematy M
AD  - Metabolic Syndrome Research Center, Department of Nutrition, School of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Kesharwani, Prashant
AU  - Kesharwani P
AUID- ORCID: 0000-0002-0890-769X
AD  - Department of Pharmaceutics, School of Pharmaceutical Education and Research, 
      Jamia Hamdard, New Delhi, India.
FAU - Sahebkar, Amirhossein
AU  - Sahebkar A
AUID- ORCID: 0000-0002-8656-1444
AD  - Applied Biomedical Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - School of Medicine, The University of Western Australia, Perth, Western 
      Australia, Australia.
AD  - Department of Biotechnology, School of Pharmacy, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20221007
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - IT942ZTH98 (Curcumin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Humans
MH  - *Curcumin/pharmacology/therapeutic use
MH  - Single-Blind Method
MH  - C-Reactive Protein
MH  - Interleukin-6
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - curcumin
OT  - cytokines
OT  - hemodialysis patients
OT  - inflammation
OT  - systematic reviews and meta-analysis
OT  - turmeric
EDAT- 2022/10/08 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/10/07 10:06
PHST- 2022/06/27 00:00 [revised]
PHST- 2022/02/03 00:00 [received]
PHST- 2022/09/18 00:00 [accepted]
PHST- 2022/10/08 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/10/07 10:06 [entrez]
AID - 10.1002/ptr.7642 [doi]
PST - ppublish
SO  - Phytother Res. 2022 Dec;36(12):4361-4370. doi: 10.1002/ptr.7642. Epub 2022 Oct 7.