PMID- 36205692
OWN - NLM
STAT- MEDLINE
DCOM- 20221230
LR  - 20230124
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 151
IP  - 1
DP  - 2023 Jan 1
TI  - Silicone Breast Implant Surface Texture Impacts Gene Expression in Periprosthetic 
      Fibrous Capsules.
PG  - 85-95
LID - 10.1097/PRS.0000000000009800 [doi]
AB  - BACKGROUND: Silicone breast implants with smooth outer shells are associated with 
      higher rates of capsular contracture, whereas textured implants have been linked 
      to the development of breast implant-associated anaplastic large cell lymphoma. 
      By assessing the gene expression profile of fibrous capsules formed in response 
      to smooth and textured implants, insight into the development of breast 
      implant-associated abnormalities can be gained. METHODS: Miniature smooth or 
      textured silicone implants were surgically inserted into female rats ( n = 10) 
      and harvested for the surrounding capsules at postoperative week 6. RNA 
      sequencing and quantitative polymerase chain reaction were performed to identify 
      genes differentially expressed between smooth and textured capsules. For clinical 
      correlation, the expression of candidate genes was assayed in implant capsules 
      harvested from human patients with and without capsular contracture. RESULTS: Of 
      18,555 differentially expressed transcripts identified, three candidate genes 
      were selected: matrix metalloproteinase-3 ( MMP3 ), troponin-T3 ( TNNT3 ), and 
      neuregulin-1 ( NRG1 ). In textured capsules, relative gene expression and 
      immunostaining of MMP3 and TNNT3 was up-regulated, whereas NRG1 was 
      down-regulated compared to smooth capsules [mean relative fold change, 8.79 ( P = 
      0.0059), 4.81 ( P = 0.0056), and 0.40 ( P < 0.0001), respectively]. 
      Immunostaining of human specimens with capsular contracture revealed similar gene 
      expression patterns to those of animal-derived smooth capsules. CONCLUSIONS: An 
      expression pattern of low MMP3 /low TNNT3 /high NRG1 is specifically associated 
      with smooth implant capsules and human implant capsules with capsular 
      contracture. The authors' clinically relevant breast implant rat model provides a 
      strong foundation to further explore the molecular genetics of implant texture 
      and its effect on breast implant-associated abnormalities. CLINICAL RELEVANCE 
      STATEMENT: The authors have demonstrated that there are distinct gene expression 
      profiles in response to smooth versus textured breast implants. Since surface 
      texture may be linked to implant-related pathology, further molecular analysis of 
      periprosthetic capsules may yield strategies to mitigate implant-related 
      complications.
CI  - Copyright (c) 2022 by the American Society of Plastic Surgeons.
FAU - Daneshgaran, Giulia
AU  - Daneshgaran G
AD  - From the Division of Plastic and Reconstructive Surgery.
AD  - Department of Surgery.
FAU - Gardner, Daniel J
AU  - Gardner DJ
AD  - From the Division of Plastic and Reconstructive Surgery.
AD  - Department of Surgery.
FAU - Chen, Hsuan-Hsiu Annie
AU  - Chen HA
AD  - From the Division of Plastic and Reconstructive Surgery.
AD  - Department of Surgery.
FAU - Niknam-Bienia, Solmaz
AU  - Niknam-Bienia S
AD  - From the Division of Plastic and Reconstructive Surgery.
AD  - Department of Surgery.
FAU - Soundararajan, Vinaya
AU  - Soundararajan V
AD  - From the Division of Plastic and Reconstructive Surgery.
AD  - Department of Surgery.
FAU - Raghuram, Anjali C
AU  - Raghuram AC
AD  - From the Division of Plastic and Reconstructive Surgery.
AD  - Department of Surgery.
FAU - Kim, Gene H
AU  - Kim GH
AD  - Department of Dermatology, University of Southern California Keck School of 
      Medicine.
FAU - Labaj, Pawel
AU  - Labaj P
AD  - Malopolska Centre of Biotechnology, Jagiellonian University.
AD  - Department of Bioinformatics, the University of Natural Resources and Life 
      Sciences, Vienna.
FAU - Kreil, David P
AU  - Kreil DP
AD  - Department of Bioinformatics, the University of Natural Resources and Life 
      Sciences, Vienna.
FAU - Wang, Charles
AU  - Wang C
AD  - Center for Genomics and Department of Basic Sciences, School of Medicine, Loma 
      Linda University.
FAU - Hong, Young-Kwon
AU  - Hong YK
AD  - From the Division of Plastic and Reconstructive Surgery.
AD  - Department of Surgery.
FAU - Wong, Alex K
AU  - Wong AK
AD  - From the Division of Plastic and Reconstructive Surgery.
AD  - Department of Surgery.
LA  - eng
PT  - Journal Article
DEP - 20221007
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - 0 (Capsules)
RN  - 0 (Silicones)
SB  - IM
MH  - Humans
MH  - Female
MH  - Rats
MH  - Animals
MH  - *Breast Implants/adverse effects
MH  - Matrix Metalloproteinase 3
MH  - Capsules
MH  - *Breast Diseases
MH  - Postoperative Complications
MH  - Silicones
MH  - Gene Expression
MH  - *Contracture
EDAT- 2022/10/08 06:00
MHDA- 2022/12/31 06:00
CRDT- 2022/10/07 10:33
PHST- 2022/10/08 06:00 [pubmed]
PHST- 2022/12/31 06:00 [medline]
PHST- 2022/10/07 10:33 [entrez]
AID - 00006534-202301000-00019 [pii]
AID - 10.1097/PRS.0000000000009800 [doi]
PST - ppublish
SO  - Plast Reconstr Surg. 2023 Jan 1;151(1):85-95. doi: 10.1097/PRS.0000000000009800. 
      Epub 2022 Oct 7.