PMID- 3620585
OWN - NLM
STAT- MEDLINE
DCOM- 19871006
LR  - 20061115
IS  - 0753-3322 (Print)
IS  - 0753-3322 (Linking)
VI  - 41
IP  - 4
DP  - 1987
TI  - Circadian rhythm of serum total immunoglobin E (IgE) in asthmatic children.
PG  - 186-8
AB  - Time of day related changes in serum total IgE (and cortisol as marker rhythm) 
      were documented in 6 non-allergic children (2 girls, 4 boys, 6 to 10 years old) 
      and 3 boys (10 to 14 years) with allergic asthma but symptom free at the time of 
      the study. Subjects were synchronized with a diurnal activity from 07.00 to 21.00 
      and a nocturnal rest. Venous blood was sampled at fixed times (07.30, 11.30, 
      16.30 and 22.30) during a 24 hours span for the healthy children and during a 48 
      hours span for the asthmatics. Radioimmunoassay methods were used for the 
      determinations. Time series were analyzed according to conventional (t tested 
      differences, ANOVA) and Cosinor methods. No IgE circadian rhythm was validated in 
      healthy children while a large amplitude (approximately equal to 30% of the 24 
      hours mean) circadian rhythm with 2 diurnal peaks and a nocturnal trough was 
      demonstrated (P less than 0.0023) in the asthmatics. Therefore, time qualified 
      references are needed for the interpretation of total IgE as they are for many 
      biological variables. Circadian rhythm of IgE is presumably related to those of 
      lymphocyte subpopulations such as B, T and T-suppressor cells.
FAU - Gaultier, C
AU  - Gaultier C
FAU - De Montis, G
AU  - De Montis G
FAU - Reinberg, A
AU  - Reinberg A
FAU - Motohashi, Y
AU  - Motohashi Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/*immunology
MH  - Child
MH  - *Circadian Rhythm
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Male
MH  - Reference Values
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
PST - ppublish
SO  - Biomed Pharmacother. 1987;41(4):186-8.