PMID- 36206994
OWN - NLM
STAT- MEDLINE
DCOM- 20221219
LR  - 20221222
IS  - 1095-9947 (Electronic)
IS  - 1050-4648 (Linking)
VI  - 131
DP  - 2022 Dec
TI  - Modulatory effects of curcumin on Singapore grouper iridovirus 
      infection-associated apoptosis and autophagy in vitro.
PG  - 84-94
LID - S1050-4648(22)00640-4 [pii]
LID - 10.1016/j.fsi.2022.09.074 [doi]
AB  - Singapore grouper iridovirus (SGIV) with high pathogenicity can cause great 
      economic losses to aquaculture industry. Thus, it is of urgency to find effective 
      antiviral strategies to combat SGIV. Curcumin has been demonstrated effective 
      antiviral activity on SGIV infection. However, the molecular mechanism behind 
      this action needs to be further explanations. In view of the fact that apoptosis 
      (type I programmed cell death) and autophagy (type II programmed cell death) were 
      key regulators during SGIV infection, we aimed to investigate the relevance 
      between antiviral activity of curcumin and SGIV-associated programmed and clarify 
      the role of potential signaling pathways. Our results showed that curcumin 
      suppressed SGIV-induced apoptosis. At the same time, the activities of 
      caspase-3/8/9 and activating protein-1 (AP-1), P53, nuclear factor-kappaB (NF-KappaB) 
      promoters were inhibited. Besides, the activation of extracellular regulated 
      protein kinases (ERK), c-Jun N-terminal kinase (JNK) and p38 mitogen activate 
      protein kinase (p38 MAPK) signal pathways were suppressed in curcumin-treated 
      cells. On the other hand, curcumin down-regulated protein kinase B 
      (AKT)/mammalian target of rapamycin (mTOR) signaling pathway to promote autophagy 
      representing by increased LC3 II and Beclin1 expression. Curcumin also hindered 
      the transition of cells from G1 to S phase, as well as down-regulating the 
      expression of CyclinD1. Our findings revealed the resistance curcumin induced to 
      the effects of DNA virus on cell apoptosis and autophagy and the insights gained 
      from this study may be of assistance to understand the molecular mechanism of 
      curcumin against DNA virus infection.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Wang, Yuexuan
AU  - Wang Y
AD  - College of Marine Sciences, South China Agricultural University, Guangdong 
      Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
FAU - Xu, Suifeng
AU  - Xu S
AD  - College of Marine Sciences, South China Agricultural University, Guangdong 
      Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
FAU - Han, Chengzong
AU  - Han C
AD  - College of Marine Sciences, South China Agricultural University, Guangdong 
      Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
FAU - Huang, Youhua
AU  - Huang Y
AD  - College of Marine Sciences, South China Agricultural University, Guangdong 
      Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
FAU - Wei, Jingguang
AU  - Wei J
AD  - College of Marine Sciences, South China Agricultural University, Guangdong 
      Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China.
FAU - Wei, Shina
AU  - Wei S
AD  - College of Marine Sciences, South China Agricultural University, Guangdong 
      Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China. Electronic 
      address: weisn@scau.edu.cn.
FAU - Qin, Qiwei
AU  - Qin Q
AD  - College of Marine Sciences, South China Agricultural University, Guangdong 
      Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China; Southern 
      Marine Science and Engineering Guangdong Laboratory, Zhuhai, 528478, China; 
      Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for 
      Marine Science and Technology, Qingdao, 266000, China. Electronic address: 
      qinqw@scau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20221004
PL  - England
TA  - Fish Shellfish Immunol
JT  - Fish & shellfish immunology
JID - 9505220
RN  - IT942ZTH98 (Curcumin)
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - Animals
MH  - *Iridovirus/physiology
MH  - *Bass
MH  - *Curcumin/pharmacology
MH  - Singapore
MH  - *Fish Diseases
MH  - *Ranavirus/physiology
MH  - *DNA Virus Infections/veterinary
MH  - Apoptosis
MH  - Autophagy
MH  - Antiviral Agents/pharmacology
MH  - Mammals
OTO - NOTNLM
OT  - Apoptosis
OT  - Autophagy
OT  - Curcumin
OT  - Singapore grouper iridovirus (SGIV)
EDAT- 2022/10/08 06:00
MHDA- 2022/12/20 06:00
CRDT- 2022/10/07 19:23
PHST- 2022/09/02 00:00 [received]
PHST- 2022/09/30 00:00 [revised]
PHST- 2022/09/30 00:00 [accepted]
PHST- 2022/10/08 06:00 [pubmed]
PHST- 2022/12/20 06:00 [medline]
PHST- 2022/10/07 19:23 [entrez]
AID - S1050-4648(22)00640-4 [pii]
AID - 10.1016/j.fsi.2022.09.074 [doi]
PST - ppublish
SO  - Fish Shellfish Immunol. 2022 Dec;131:84-94. doi: 10.1016/j.fsi.2022.09.074. Epub 
      2022 Oct 4.