PMID- 36207795
OWN - NLM
STAT- MEDLINE
DCOM- 20221011
LR  - 20221026
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 10
IP  - 19
DP  - 2022 Oct
TI  - Associating local strains to global pressure-volume mouse lung mechanics using 
      digital image correlation.
PG  - e15466
LID - 10.14814/phy2.15466 [doi]
LID - e15466
AB  - Pulmonary diseases alter lung mechanical properties, can cause loss of function, 
      and necessitate use of mechanical ventilation, which can be detrimental. 
      Investigations of lung tissue (local) scale mechanical properties are sparse 
      compared to that of the whole organ (global) level, despite connections between 
      regional strain injury and ventilation. We examine ex vivo mouse lung mechanics 
      by investigating strain values, local compliance, tissue surface heterogeneity, 
      and strain evolutionary behavior for various inflation rates and volumes. A 
      custom electromechanical, pressure-volume ventilator is coupled with digital 
      image correlation to measure regional lung strains and associate local to global 
      mechanics by analyzing novel pressure-strain evolutionary measures. Mean strains 
      at 5 breaths per minute (BPM) for applied volumes of 0.3, 0.5, and 0.7 ml are 
      5.0, 7.8, and 11.3%, respectively, and 4.7, 8.8, and 12.2% for 20 BPM. Similarly, 
      maximum strains among all rate and volume combinations range 10.7%-22.4%. Strain 
      values (mean, range, mode, and maximum) at peak inflation often exhibit 
      significant volume dependencies. Additionally, select evolutionary behavior 
      (e.g., local lung compliance quantification) and tissue heterogeneity show 
      significant volume dependence. Rate dependencies are generally found to be 
      insignificant; however, strain values and surface lobe heterogeneity tend to 
      increase with increasing rates. By quantifying strain evolutionary behavior in 
      relation to pressure-volume measures, we associate time-continuous local to 
      global mouse lung mechanics for the first time and further examine the role of 
      volume and rate dependency. The interplay of multiscale deformations evaluated in 
      this work can offer insights for clinical applications, such as 
      ventilator-induced lung injury.
CI  - (c) 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on 
      behalf of The Physiological Society and the American Physiological Society.
FAU - Nelson, Talyah M
AU  - Nelson TM
AD  - Department of Mechanical Engineering, University of California, Riverside, 
      California, USA.
FAU - Quiros, Kathrine A M
AU  - Quiros KAM
AD  - Department of Mechanical Engineering, University of California, Riverside, 
      California, USA.
FAU - Mariano, Crystal A
AU  - Mariano CA
AD  - Department of Mechanical Engineering, University of California, Riverside, 
      California, USA.
FAU - Sattari, Samaneh
AU  - Sattari S
AD  - Department of Mechanical Engineering, University of California, Riverside, 
      California, USA.
FAU - Ulu, Arzu
AU  - Ulu A
AD  - BREATHE Center, School of Medicine University of California, Riverside, 
      California, USA.
AD  - Division of Biomedical Sciences, School of Medicine, University of California, 
      Riverside, California, USA.
FAU - Dominguez, Edward C
AU  - Dominguez EC
AD  - BREATHE Center, School of Medicine University of California, Riverside, 
      California, USA.
AD  - Division of Biomedical Sciences, School of Medicine, University of California, 
      Riverside, California, USA.
FAU - Nordgren, Tara M
AU  - Nordgren TM
AD  - BREATHE Center, School of Medicine University of California, Riverside, 
      California, USA.
AD  - Division of Biomedical Sciences, School of Medicine, University of California, 
      Riverside, California, USA.
FAU - Eskandari, Mona
AU  - Eskandari M
AUID- ORCID: 0000-0002-9657-2614
AD  - Department of Mechanical Engineering, University of California, Riverside, 
      California, USA.
AD  - BREATHE Center, School of Medicine University of California, Riverside, 
      California, USA.
AD  - Department of Bioengineering, University of California, Riverside, California, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
SB  - IM
MH  - Animals
MH  - Lung
MH  - Lung Compliance
MH  - Lung Volume Measurements
MH  - Mice
MH  - *Respiration, Artificial/methods
MH  - *Respiratory Mechanics
MH  - Tidal Volume
PMC - PMC9547081
OTO - NOTNLM
OT  - compliance
OT  - digital image correlation
OT  - heterogeneity
OT  - lung
OT  - real-time
OT  - strain
EDAT- 2022/10/09 06:00
MHDA- 2022/10/12 06:00
PMCR- 2022/10/07
CRDT- 2022/10/08 00:52
PHST- 2022/08/22 00:00 [revised]
PHST- 2022/05/19 00:00 [received]
PHST- 2022/08/28 00:00 [accepted]
PHST- 2022/10/08 00:52 [entrez]
PHST- 2022/10/09 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/10/07 00:00 [pmc-release]
AID - PHY215466 [pii]
AID - 10.14814/phy2.15466 [doi]
PST - ppublish
SO  - Physiol Rep. 2022 Oct;10(19):e15466. doi: 10.14814/phy2.15466.