PMID- 36210268
OWN - NLM
STAT- MEDLINE
DCOM- 20221124
LR  - 20230209
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 144
DP  - 2022 Dec
TI  - High-frequency oscillations-based precise temporal resolution of short latency 
      afferent inhibition in the human brain.
PG  - 135-141
LID - S1388-2457(22)00892-6 [pii]
LID - 10.1016/j.clinph.2022.09.006 [doi]
AB  - OBJECTIVE: Sensorimotor integration is a crucial process for adaptive behaviour 
      and can be explored non-invasively with a conditioned transcranial magnetic 
      stimulation (TMS) paradigm - i.e. short-latency afferent inhibition (SAI). To 
      gain insight into the sensorimotor integration phenomenon, we used two different 
      approaches to combine peripheral and cortical stimulation in the SAI paradigm, 
      measuring not only the latency of low frequency somatosensory evoked potentials 
      (SEPs) but also the peaks of high frequency oscillations (HFOs) underlying SEPs. 
      METHODS: The interstimulus intervals (ISIs) between the electrical stimulation of 
      the median nerve and the motor cortex magnetic stimulation were determined 
      relative to the latency of the earliest SEPs cortical potential (N20) or the HFOs 
      peaks. In particular, the first and last negative and positive peaks of HFOs were 
      extracted through a custom-made MATLAB script. RESULTS: Thirty-three healthy 
      subjects participated in this study. We found out that muscle responses after TMS 
      were suppressed when ISIs were comprised between -1 to +3 ms relative to the N20 
      peak and at all ISIs relative to HFOs peaks, except for the first negative peak. 
      CONCLUSIONS: Coupling peripheral and cortical stimulation at early interstimulus 
      intervals - before the SEPs N20 peak - may modulate muscle response. 
      SIGNIFICANCE: Our findings confirm that afferent inhibition is produced both 
      through a direct (thalamus-motor cortex) and indirect 
      (thalamus-somatosensory-motor cortex) pathway.
CI  - Copyright (c) 2022 International Federation of Clinical Neurophysiology. Published 
      by Elsevier B.V. All rights reserved.
FAU - Motolese, Francesco
AU  - Motolese F
AD  - Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, 
      Universita Campus Bio-Medico di Roma, Rome, Italy. Electronic address: 
      f.motolese@policlinicocampus.it.
FAU - Rossi, Mariagrazia
AU  - Rossi M
AD  - Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, 
      Universita Campus Bio-Medico di Roma, Rome, Italy.
FAU - Capone, Fioravante
AU  - Capone F
AD  - Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, 
      Universita Campus Bio-Medico di Roma, Rome, Italy.
FAU - Cruciani, Alessandro
AU  - Cruciani A
AD  - Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, 
      Universita Campus Bio-Medico di Roma, Rome, Italy.
FAU - Musumeci, Gabriella
AU  - Musumeci G
AD  - Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, 
      Universita Campus Bio-Medico di Roma, Rome, Italy.
FAU - Manzo, Marco
AU  - Manzo M
AD  - Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, 
      Universita Campus Bio-Medico di Roma, Rome, Italy.
FAU - Pilato, Fabio
AU  - Pilato F
AD  - Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, 
      Universita Campus Bio-Medico di Roma, Rome, Italy.
FAU - Di Pino, Giovanni
AU  - Di Pino G
AD  - Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, 
      Universita Campus Bio-Medico di Roma, Rome, Italy; Research Unit of 
      Neurophysiology and Neuroengineering of Human-Technology Interaction, Department 
      of Medicine, Universita Campus Bio-Medico di Roma, Rome, Italy.
FAU - Di Lazzaro, Vincenzo
AU  - Di Lazzaro V
AD  - Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, 
      Universita Campus Bio-Medico di Roma, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220923
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
CIN - Clin Neurophysiol. 2022 Dec;144:119-120. PMID: 36244913
MH  - Humans
MH  - *Evoked Potentials, Motor/physiology
MH  - Neural Inhibition/physiology
MH  - Transcranial Magnetic Stimulation
MH  - *Motor Cortex/physiology
MH  - Evoked Potentials, Somatosensory/physiology
MH  - Median Nerve/physiology
MH  - Electric Stimulation
MH  - Afferent Pathways/physiology
OTO - NOTNLM
OT  - HFOs
OT  - High-frequency oscillations
OT  - SAI
OT  - Sensorimotor integration
OT  - Short-latency afferent inhibition
EDAT- 2022/10/10 06:00
MHDA- 2022/11/25 06:00
CRDT- 2022/10/09 22:05
PHST- 2022/06/12 00:00 [received]
PHST- 2022/09/08 00:00 [revised]
PHST- 2022/09/15 00:00 [accepted]
PHST- 2022/10/10 06:00 [pubmed]
PHST- 2022/11/25 06:00 [medline]
PHST- 2022/10/09 22:05 [entrez]
AID - S1388-2457(22)00892-6 [pii]
AID - 10.1016/j.clinph.2022.09.006 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2022 Dec;144:135-141. doi: 10.1016/j.clinph.2022.09.006. Epub 
      2022 Sep 23.