PMID- 36211067
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221011
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 7
IP  - 39
DP  - 2022 Oct 4
TI  - Rapid Sublingual Delivery of Piroxicam from Electrospun Cyclodextrin Inclusion 
      Complex Nanofibers.
PG  - 35083-35091
LID - 10.1021/acsomega.2c03987 [doi]
AB  - Piroxicam (Px) is a nonsteroidal anti-inflammatory drug (NSAID) used for the 
      treatment of osteoarthritis and rheumatoid arthritis. It is administered orally; 
      however, its poor water solubility causes low loading to the nonconventional drug 
      delivery systems (DDSs), such as electrospun fibers. Furthermore, the rapid 
      dissolution of DDS and fast release of the embedded drugs are crucial for oral 
      delivery of drugs to patients who are unconscious or suffering from dysphagia. In 
      this regard, this study reports the development of rapidly dissolving 
      cyclodextrin (CD)-based inclusion complex (IC) nanofibers by waterborne 
      electrospinning for fast oral delivery of Px. Scanning electron microscopy 
      analysis revealed the formation of bead-free fibers with a mean diameter range of 
      170-500 nm at various concentrations of Px; increasing the Px loading decreased 
      the fiber diameter. The formation of IC was demonstrated by X-ray diffraction 
      (XRD) analysis by the disappearance of crystalline peaks of Px. Likewise, 
      differential scanning calorimetry (DSC) analysis showed the disappearance of the 
      melting peak of the embedded Px due to IC formation. Both Fourier transform 
      infrared (FTIR) and thermogravimetric analysis (TGA) confirmed the presence of Px 
      within the fibers. (1)H NMR experiments demonstrated Px preservation in the 
      fibers after six months. Px-loaded nanofibers were employed for sublingual drug 
      delivery. To mimic the environment of the mouth, the nanofibers were treated with 
      artificial saliva, which revealed the instant dissolution of the nanofibers. 
      Furthermore, dissolution experiments were performed on the tissues wetted with 
      artificial saliva, where the dissolution of the fibers could be extended to a few 
      seconds, demonstrating the suitability of the materials for sublingual oral drug 
      delivery. Overall, this paper, for the first time, reports the rapid oral 
      delivery of Px from polymer-free CD fibers produced by waterborne electrospinning 
      without the requirement of any carrier polymer and toxic solvent.
CI  - (c) 2022 The Author. Published by American Chemical Society.
FAU - Topuz, Fuat
AU  - Topuz F
AUID- ORCID: 0000-0002-9011-4495
AD  - Department of Chemistry, Faculty of Science and Letters, Istanbul Technical 
      University, Sariyer, 34467 Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220919
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC9535703
COIS- The author declares no competing financial interest.
EDAT- 2022/10/11 06:00
MHDA- 2022/10/11 06:01
PMCR- 2022/09/19
CRDT- 2022/10/10 03:48
PHST- 2022/06/26 00:00 [received]
PHST- 2022/09/08 00:00 [accepted]
PHST- 2022/10/10 03:48 [entrez]
PHST- 2022/10/11 06:00 [pubmed]
PHST- 2022/10/11 06:01 [medline]
PHST- 2022/09/19 00:00 [pmc-release]
AID - 10.1021/acsomega.2c03987 [doi]
PST - epublish
SO  - ACS Omega. 2022 Sep 19;7(39):35083-35091. doi: 10.1021/acsomega.2c03987. 
      eCollection 2022 Oct 4.