PMID- 36212038
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230918
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 14
DP  - 2022
TI  - The functional connectivity of language network across the life span: 
      Disentangling the effects of typical aging from Alzheimer's disease.
PG  - 959405
LID - 10.3389/fnagi.2022.959405 [doi]
LID - 959405
AB  - Language is usually characterized as the most preserved cognitive function during 
      typical aging. Several neuroimaging studies have shown that healthy aging is 
      characterized by inter-network compensation which correlates with better language 
      performance. On the contrary, language deficits occur early in the course of 
      Alzheimer's disease (AD). Therefore, this study compares young participants, 
      healthy older participants, and prodromal AD participants, to characterize 
      functional connectivity changes in language due to healthy aging or prodromal AD. 
      We first compared measures of integrated local correlations (ILCs) and fractional 
      amplitude of low-frequency oscillations (fALFFs) in language areas. We showed 
      that both groups of older adults had lower connectivity values within frontal 
      language-related areas. In the healthy older group, higher integrated local 
      correlation (ILC) and fALFF values in frontal areas were positively correlated 
      with fluency and naming tasks. We then performed seed-based analyses for more 
      precise discrimination between healthy aging and prodromal AD. Healthy older 
      adults showed no functional alterations at a seed-based level when the seed area 
      was not or only slightly impaired compared to the young adults [i.e., inferior 
      frontal gyrus (IFG)], while prodromal AD participants also showed decreased 
      connectivity at a seed-based level. On the contrary, when the seed area was 
      similarly impaired in healthy older adults and prodromal AD participants on ILC 
      and fALFF measures, their connectivity maps were also similar during 
      seed-to-voxel analyses [i.e., superior frontal gyrus (SFG)]. Current results show 
      that functional connectivity measures at a voxel level (ILC and fALFF) are 
      already impacted in healthy aging. These findings imply that the functional 
      compensations observed in healthy aging depend on the functional integrity of 
      brain areas at a voxel level.
CI  - Copyright (c) 2022 Rafiq, Jucla, Guerrier, Peran, Pariente and Pistono.
FAU - Rafiq, Marie
AU  - Rafiq M
AD  - Department of Neurology, Neuroscience Centre, Toulouse University Hospital, 
      Toulouse, France.
AD  - Toulouse NeuroImaging Center, Toulouse University, Inserm, University Paul 
      Sabatier (UPS), Toulouse, France.
FAU - Jucla, Melanie
AU  - Jucla M
AD  - Octogone-Lordat Interdisciplinary Research Unit (EA 4156), University of Toulouse 
      II-Jean Jaures, Toulouse, France.
FAU - Guerrier, Laura
AU  - Guerrier L
AD  - Toulouse NeuroImaging Center, Toulouse University, Inserm, University Paul 
      Sabatier (UPS), Toulouse, France.
FAU - Peran, Patrice
AU  - Peran P
AD  - Toulouse NeuroImaging Center, Toulouse University, Inserm, University Paul 
      Sabatier (UPS), Toulouse, France.
FAU - Pariente, Jeremie
AU  - Pariente J
AD  - Department of Neurology, Neuroscience Centre, Toulouse University Hospital, 
      Toulouse, France.
AD  - Toulouse NeuroImaging Center, Toulouse University, Inserm, University Paul 
      Sabatier (UPS), Toulouse, France.
FAU - Pistono, Aurelie
AU  - Pistono A
AD  - Department of Experimental Psychology, Ghent University, Ghent, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20220923
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC9537133
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - aging
OT  - functional connectivity
OT  - language
OT  - language network
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/11 06:00
MHDA- 2022/10/11 06:01
PMCR- 2022/01/01
CRDT- 2022/10/10 04:04
PHST- 2022/06/01 00:00 [received]
PHST- 2022/08/29 00:00 [accepted]
PHST- 2022/10/10 04:04 [entrez]
PHST- 2022/10/11 06:00 [pubmed]
PHST- 2022/10/11 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2022.959405 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2022 Sep 23;14:959405. doi: 10.3389/fnagi.2022.959405. 
      eCollection 2022.