PMID- 36212172
OWN - NLM
STAT- MEDLINE
DCOM- 20221011
LR  - 20221011
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2022
DP  - 2022
TI  - Identification of Significant Genes and Pathways for the Chronic and Subacute 
      Cutaneous Lupus Erythematosus via Bioinformatics Analysis.
PG  - 9891299
LID - 10.1155/2022/9891299 [doi]
LID - 9891299
AB  - BACKGROUND: Chronic cutaneous lupus erythematosus (CCLE) and subacute cutaneous 
      lupus erythematosus (SCLE) are both common variants of cutaneous lupus 
      erythematosus (CLE) that mainly involve the skin and mucous membrane. Oral 
      mucosal involvement is frequently observed in patients of CLE. Despite that they 
      have different clinicopathological features, whether there is a significant 
      difference in pathogenesis between them remains unclear. Herein, we investigated 
      specific genes and pathways of SCLE and CCLE via bioinformatics analysis. 
      METHODS: Microarray expression datasets of GSE109248 and GSE112943 were both 
      retrieved from the GEO database. Differentially expressed genes (DEGs) between 
      CCLE or SCLE skin tissues and health controls were selected by GEO2R. Common DEGs 
      were picked out via the Venn diagram software. Then, functional enrichment and 
      PPI network analysis were conducted, and the top 10 key genes were identified via 
      Cytohubba. RESULTS: Totally, 176 DEGs of SCLE and 287 DEGs of CCLE were 
      identified. The GO enrichment and KEGG analysis of DEGs of SCLE is significantly 
      enriched in the response to virus, defense response to virus, response to 
      IFN-gamma, cellular response to IFN-gamma, type I IFN signaling pathway, chemokine 
      activity, chemokine receptor binding, NOD-like receptor signaling pathway, etc. 
      The GO enrichment and KEGG analysis of DEGs of CCLE is significantly enriched in 
      the response to virus, regulation of multiorganism process, negative regulation 
      of viral process, regulation of lymphocyte activation, chemokine receptor 
      binding, CCR chemokine receptor binding, NOD-like receptor signaling pathway, 
      etc. The top 10 hub genes of SCLE and CCLE, respectively, include STAT1, CXCL10, 
      IRF7, ISG15, and RSAD2 and CXCL10, IRF7, IFIT3, CTLA4, and ISG15. CONCLUSION: Our 
      finding suggests that SCLE and CCLE have the similar potential key genes and 
      pathways and majority of them belong to IFN signatures and IFN signaling pathway. 
      Besides, the NOD-like receptor signaling pathway might also have an essential 
      role in the pathogenesis of SCLE and CCLE. Together, the identified genes and 
      signaling pathways have enhanced our understanding of the mechanism underlying 
      the occurrence and development of both SCLE and CCLE.
CI  - Copyright (c) 2022 Yan Teng et al.
FAU - Teng, Yan
AU  - Teng Y
AD  - Health Management Center, Department of Dermatology, Zhejiang Provincial People's 
      Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 
      310014, China.
FAU - Li, Sujing
AU  - Li S
AD  - Bengbu Medical College, Bengbu, China.
FAU - Ding, Yang
AU  - Ding Y
AD  - Health Management Center, Department of Dermatology, Zhejiang Provincial People's 
      Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 
      310014, China.
FAU - Fan, Yibin
AU  - Fan Y
AD  - Health Management Center, Department of Dermatology, Zhejiang Provincial People's 
      Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 
      310014, China.
FAU - He, Miao
AU  - He M
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, 
      410008 Hunan, China.
FAU - Li, Hengzhen
AU  - Li H
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, 
      410008 Hunan, China.
FAU - Tao, Xiaohua
AU  - Tao X
AD  - Health Management Center, Department of Dermatology, Zhejiang Provincial People's 
      Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 
      310014, China.
FAU - Huang, Youming
AU  - Huang Y
AUID- ORCID: 0000-0001-7871-1644
AD  - Health Management Center, Department of Dermatology, Zhejiang Provincial People's 
      Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 
      310014, China.
LA  - eng
PT  - Journal Article
DEP - 20220929
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (Chemokines)
RN  - 0 (NLR Proteins)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - CTLA-4 Antigen
MH  - Chemokines
MH  - Computational Biology
MH  - *Graft vs Host Disease
MH  - Humans
MH  - *Lupus Erythematosus, Cutaneous/genetics/pathology
MH  - *Lupus Erythematosus, Discoid/genetics/pathology
MH  - NLR Proteins
MH  - Receptors, Chemokine
PMC - PMC9537011
COIS- The authors declare no conflicting interests.
EDAT- 2022/10/11 06:00
MHDA- 2022/10/12 06:00
PMCR- 2022/09/29
CRDT- 2022/10/10 04:07
PHST- 2022/07/04 00:00 [received]
PHST- 2022/07/26 00:00 [revised]
PHST- 2022/09/10 00:00 [accepted]
PHST- 2022/10/10 04:07 [entrez]
PHST- 2022/10/11 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/09/29 00:00 [pmc-release]
AID - 10.1155/2022/9891299 [doi]
PST - epublish
SO  - Dis Markers. 2022 Sep 29;2022:9891299. doi: 10.1155/2022/9891299. eCollection 
      2022.