PMID- 36213264
OWN - NLM
STAT- MEDLINE
DCOM- 20221011
LR  - 20221207
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - A functional polymorphism of microRNA-143 is associated with the risk of type 2 
      diabetes mellitus in the northern Chinese Han population.
PG  - 994953
LID - 10.3389/fendo.2022.994953 [doi]
LID - 994953
AB  - OBJECTIVE: To explore the association between two polymorphisms of microRNA-143 
      (miR-143) and the risk of type 2 diabetes mellitus (T2DM) in the northern Chinese 
      Han population. STUDY DESIGN: This case-control study involved 326 patients with 
      T2DM and 342 healthy controls. Two genetic variants (rs4705342 and rs353292) of 
      miR-143 were genotyped by the polymerase chain reaction/ligase detection reaction 
      (PCR-LDR) method. The levels of miR-143 in the serum from 52 T2DM patients and 55 
      healthy subjects were investigated by quantitative real-time PCR (qRT-PCR). 
      RESULTS: The CC genotype frequency of rs4705342 was significantly higher in the 
      T2DM patients than in the healthy controls (P = 0.012). After adjusting for sex, 
      age, and body mass index, the rs4705342 CC genotype was also related to a 
      significantly increased risk of T2DM compared with the TT genotype (adjusted OR: 
      1.87; 95% CI = 1.09-3.19; P = 0.022). Stratified analyses demonstrated that T2DM 
      patients with the rs4705342 CC genotype had significantly higher levels of 
      low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), and 
      glycated haemoglobin (HbA1C) than those carrying the rs4705342 TT genotype. The 
      qRT-PCR results showed that the expression levels of miR-143 were significantly 
      higher in the serum of cases than in the serum of controls (P < 0.001). 
      Furthermore, the levels of miR-143 were significantly higher in the serum of T2DM 
      patients carrying the rs4705342 CC genotype than in those carrying the TC and TT 
      genotypes of rs4705342 (P = 0.005 and 0.003, respectively). CONCLUSION: The CC 
      genotype of rs4705342 might be a risk factor for developing T2DM by increasing 
      the expression of miRNA-143 in the northern Chinese Han population.
CI  - Copyright (c) 2022 Kong, Duan, Wang and Liu.
FAU - Kong, Dexian
AU  - Kong D
AD  - Department of Endocrinology, Fourth Affiliated Hospital, Hebei Medical 
      University, Shijiazhuang, China.
FAU - Duan, Ya
AU  - Duan Y
AD  - Department of Obstetrics, Hebei General Hospital, Shijiazhuang, China.
FAU - Wang, Jinli
AU  - Wang J
AD  - Department of Infirmary, Hebei Public Security Police Vocational College, 
      Shijiazhuang, China.
FAU - Liu, Yabin
AU  - Liu Y
AD  - Department of General Surgery, Fourth Affiliated Hospital, Hebei Medical 
      University, Shijiazhuang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220923
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (MIRN143 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - EC 6.- (Ligases)
SB  - IM
MH  - Blood Glucose
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Cholesterol, LDL
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Genetic Predisposition to Disease
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Ligases/genetics
MH  - *MicroRNAs/genetics
MH  - Polymorphism, Single Nucleotide
PMC - PMC9538736
OTO - NOTNLM
OT  - MiRNA-143
OT  - expression
OT  - polymorphism
OT  - risk
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/11 06:00
MHDA- 2022/10/12 06:00
PMCR- 2022/01/01
CRDT- 2022/10/10 04:28
PHST- 2022/07/15 00:00 [received]
PHST- 2022/09/05 00:00 [accepted]
PHST- 2022/10/10 04:28 [entrez]
PHST- 2022/10/11 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.994953 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Sep 23;13:994953. doi: 
      10.3389/fendo.2022.994953. eCollection 2022.