PMID- 36213963
OWN - NLM
STAT- MEDLINE
DCOM- 20230323
LR  - 20230323
IS  - 1552-4175 (Electronic)
IS  - 1099-8004 (Linking)
VI  - 25
IP  - 2
DP  - 2023 Apr
TI  - Effects of Exercise Training on Inflammatory and Cardiometabolic Risk Biomarkers 
      in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis 
      of Randomized Controlled Trials.
PG  - 250-266
LID - 10.1177/10998004221132841 [doi]
AB  - BACKGROUND: The interaction between type 2 diabetes mellitus (T2DM) and 
      cardiometabolic morbidity and mortality stems from the progressive nature of 
      inflammation underpinning both diseases. Exercise training is considered an 
      effective treatment strategy for T2DM and cardiometabolic diseases. OBJECTIVE: 
      The current systematic review and meta-analysis investigated the effects of 
      exercise training on inflammatory and cardiometabolic risk biomarkers in patients 
      with T2DM. DATA SOURCES: Electronic databases (PubMed/Medline, Embase, Cochrane 
      Library, CINAHL, Google Scholar, Scopus, and Web of Science) were searched for 
      randomized controlled trials (RCTs) from inception to January 2022. We used 
      random effects models to estimate weighted mean differences with 95% confidence 
      intervals. STUDY SELECTION: Twenty-five RCTs were included (N = 1257 
      participants; mean age = 52 years). Included studies had moderate to good overall 
      methodological quality (TESTEX = 9 (range 7-13). RESULTS: Meta-analysis indicated 
      that exercise training significantly increased adiponectin and decreased fasting 
      insulin, homeostatic model assessment for insulin resistance, tumor necrosis 
      factor-alpha, interleukin-6, and C-reactive protein (ps </= 0.05). Subgroup analysis by 
      type of training indicated that aerobic exercise had the most consistent 
      beneficial effects as compared to other types of exercise training; however, 
      there was high heterogeneity among studies. CONCLUSION: Different types of 
      exercise training increase adiponectin levels and decrease pro-inflammatory 
      cytokines such as TNF-alpha, IL-6, and CRP, as well as fasting insulin and insulin 
      resistance markers in patients with T2DM. However, these effects were not 
      beneficial for more commonly measured cardiometabolic risk factors (i.e., lipid 
      profiles). Additional relevant clinical trials are required to confirm these 
      results. TRIAL REGISTRATION: This systematic review and meta-analysis was 
      prospectively registered in the PROSPERO database (CRD42022307396).
FAU - Hejazi, Keyvan
AU  - Hejazi K
AUID- ORCID: 0000-0002-4590-8018
AD  - Department of Physical Education and Sport Sciences, 185150Hakim Sabzevari 
      University, Sabzevar, Iran.
FAU - Mohammad Rahimi, Gholam Rasul
AU  - Mohammad Rahimi GR
AUID- ORCID: 0000-0002-8159-2065
AD  - Faculty of Sport Sciences, Department of Exercise Physiology, 48440Ferdowsi 
      University of Mashhad, Mashhad, Iran.
FAU - Rosenkranz, Sara K
AU  - Rosenkranz SK
AUID- ORCID: 0000-0002-3297-1640
AD  - Department of Kinesiology and Nutrition Sciences, School of Integrated Health 
      Sciences, University of Nevada, Las Vegas, Las Vegas, NV, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20221010
PL  - United States
TA  - Biol Res Nurs
JT  - Biological research for nursing
JID - 9815758
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Adiponectin/analysis
MH  - Biomarkers/analysis
MH  - *Cardiovascular Diseases/prevention & control/therapy
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - Exercise
MH  - Insulin/analysis
MH  - *Insulin Resistance
MH  - Interleukin-6/analysis
MH  - Randomized Controlled Trials as Topic
MH  - Tumor Necrosis Factor-alpha/analysis
OTO - NOTNLM
OT  - diabetes
OT  - exercise training
OT  - inflammatory biomarkers
OT  - meta-analysis
EDAT- 2022/10/11 06:00
MHDA- 2023/03/21 06:00
CRDT- 2022/10/10 04:41
PHST- 2022/10/11 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
PHST- 2022/10/10 04:41 [entrez]
AID - 10.1177/10998004221132841 [doi]
PST - ppublish
SO  - Biol Res Nurs. 2023 Apr;25(2):250-266. doi: 10.1177/10998004221132841. Epub 2022 
      Oct 10.