PMID- 36214127
OWN - NLM
STAT- MEDLINE
DCOM- 20230130
LR  - 20230403
IS  - 1029-2330 (Electronic)
IS  - 1026-7158 (Linking)
VI  - 31
IP  - 2
DP  - 2023 Feb
TI  - Titanium surface polyethylene glycol hydrogel and gentamicin-loaded cross-linked 
      starch microspheres release system for anti-infective drugs.
PG  - 217-224
LID - 10.1080/1061186X.2022.2134395 [doi]
AB  - OBJECTIVE: To design and construct a hydrogel drug-controlled release system 
      loaded with gentamicin on a titanium surface, and to evaluate the in vitro drug 
      release behaviour and antibacterial properties and biocompatibility of the 
      controlled release system. METHODS: Titanium (Ti) surface was coated with poly 
      dopamine (PDA) substrate, and then polyethylene glycol (PEG) was attached to PDA. 
      The composite drug microsphere controlled release layer formed by gentamicin 
      (GEN) and cross-linked starch (CSt) were subsequently covered with poly 
      lactic rectangleco rectangleglycolic acid (PLGA) as a barrier to construct a Ti-GEN-Cst-PLGA 
      anti-infective drug controlled release system. RESULTS: The hydrogel drug release 
      system was successfully constructed. The results of in vitro anti-staphylococcus 
      aureus (SAU) assay, anti-staphylococcus epidermidis (SEP) assay and 
      anti-Escherichia coli (ECO) assay showed that Ti-GEN-Cst-PLGA could effectively 
      inhibit the growth of three bacteria. Assay in the New Zealand rabbit found that 
      Ti-GEN-Cst-PLGA could promote wound healing at the 3rd week after implantation, 
      and the pathology assay found that the Ti-GEN-Cst-PLGA group had less 
      inflammatory reactions and significant tissue proliferation at the endophyte 
      contact surface. CONCLUSION: Ti-GEN-Cst-PLGA can effectively inhibit the 
      inflammatory response and promote wound healing, or may be a potential treatment 
      for orthopaedic endophytes.
FAU - Wu, Yunfeng
AU  - Wu Y
AD  - Medical School of Chinese PLA, Beijing, China.
AD  - Department of Orthopedics, The Eighth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Hu, Fanqi
AU  - Hu F
AD  - Department of Orthopedics, The Eighth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Yang, Xiaoqing
AU  - Yang X
AD  - Department of Orthopedics, The Eighth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Zhang, Shaofu
AU  - Zhang S
AD  - Department of Orthopedics, The Eighth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
FAU - Jia, Chengqi
AU  - Jia C
AD  - Medical School of Chinese PLA, Beijing, China.
FAU - Liu, Xiaole
AU  - Liu X
AD  - Medical School of Chinese PLA, Beijing, China.
FAU - Zhang, Xuesong
AU  - Zhang X
AD  - Department of Orthopedics, The Eighth Medical Centre, Chinese PLA General 
      Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20221019
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - D1JT611TNE (Titanium)
RN  - 0 (Gentamicins)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Biocompatible Materials)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 0 (Hydrogels)
RN  - 9005-25-8 (Starch)
SB  - IM
MH  - Animals
MH  - Rabbits
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - *Titanium/pharmacology
MH  - *Gentamicins/pharmacology
MH  - Delayed-Action Preparations
MH  - Microspheres
MH  - Biocompatible Materials
MH  - Polyethylene Glycols/chemistry
MH  - Hydrogels
MH  - Starch/chemistry
OTO - NOTNLM
OT  - Titanium
OT  - antibacterial
OT  - gentamicin
OT  - hydrogel drug release system
EDAT- 2022/10/11 06:00
MHDA- 2023/01/31 06:00
CRDT- 2022/10/10 05:03
PHST- 2022/10/11 06:00 [pubmed]
PHST- 2023/01/31 06:00 [medline]
PHST- 2022/10/10 05:03 [entrez]
AID - 10.1080/1061186X.2022.2134395 [doi]
PST - ppublish
SO  - J Drug Target. 2023 Feb;31(2):217-224. doi: 10.1080/1061186X.2022.2134395. Epub 
      2022 Oct 19.