PMID- 36214523
OWN - NLM
STAT- MEDLINE
DCOM- 20230309
LR  - 20230309
IS  - 1943-7730 (Electronic)
IS  - 0007-5027 (Linking)
VI  - 54
IP  - 2
DP  - 2023 Mar 7
TI  - Association of the rs3856806 Polymorphism in the PPARG Gene with Type 2 Diabetes 
      Mellitus: A Meta-Analysis of 11,811 Individuals.
PG  - 193-198
LID - 10.1093/labmed/lmac095 [doi]
AB  - This study investigated the role of the rs3856806 single nucleotide variant (SNV) 
      on the peroxisome proliferator-activated receptor gamma with the development of type 
      2 diabetes mellitus (T2DM) by conducting a meta-analysis. Relevant studies were 
      searched in PubMed and were selected according to the inclusion criteria. Data 
      were extracted and subjected to analysis using Review Manager 5.4.1. Pooled odds 
      ratios (OR) and 95% confidence intervals (CI) were computed to measure the 
      association of the SNV with T2DM development. Nine studies published in English 
      were retrieved up to October 1, 2021. Homogeneity (I2 = 3%, P = .41) was achieved 
      for the allelic model with significant outcomes (OR: 0.82; 95% CI: 0.76-0.89; P < 
      .00001). Genotypic models also yielded significant associations for the 
      co-dominant, dominant, and recessive models. All genotypic analysis showed 
      homogeneity (I2 = 0-31%, P = .17-0.76) of the pooled outcomes. Our findings 
      suggest that carrying the T allele of the rs3856806 SNV significantly decreases 
      the risk of acquiring T2DM. However, further studies are necessary to support our 
      claims.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of American 
      Society for Clinical Pathology. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Tiongco, Raphael Enrique
AU  - Tiongco RE
AUID- ORCID: 0000-0002-7793-6558
AD  - Department of Medical Technology, College of Allied Medical Professions, Angeles 
      University Foundation, Angeles City, Philippines.
FAU - Basilio, Henry
AU  - Basilio H
AD  - Department of Medical Technology, College of Allied Medical Professions, Angeles 
      University Foundation, Angeles City, Philippines.
FAU - Camacho, Dharleen Ryanne
AU  - Camacho DR
AD  - Department of Medical Technology, College of Allied Medical Professions, Angeles 
      University Foundation, Angeles City, Philippines.
FAU - Ellorin, Willie Mae
AU  - Ellorin WM
AD  - Department of Medical Technology, College of Allied Medical Professions, Angeles 
      University Foundation, Angeles City, Philippines.
FAU - Sico, Clarisse Arianne
AU  - Sico CA
AD  - Department of Medical Technology, College of Allied Medical Professions, Angeles 
      University Foundation, Angeles City, Philippines.
FAU - Arceo, Engracia
AU  - Arceo E
AD  - Department of Medical Technology, College of Allied Medical Professions, Angeles 
      University Foundation, Angeles City, Philippines.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - England
TA  - Lab Med
JT  - Laboratory medicine
JID - 0250641
RN  - 0 (PPAR gamma)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - PPAR gamma/genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
OTO - NOTNLM
OT  - PPARG
OT  - gene polymorphism
OT  - meta-analysis
OT  - rs3856806
OT  - single nucleotide variant
OT  - type 2 diabetes mellitus
EDAT- 2022/10/11 06:00
MHDA- 2023/03/10 06:00
CRDT- 2022/10/10 08:43
PHST- 2022/10/11 06:00 [pubmed]
PHST- 2023/03/10 06:00 [medline]
PHST- 2022/10/10 08:43 [entrez]
AID - 6754791 [pii]
AID - 10.1093/labmed/lmac095 [doi]
PST - ppublish
SO  - Lab Med. 2023 Mar 7;54(2):193-198. doi: 10.1093/labmed/lmac095.