PMID- 36214865
OWN - NLM
STAT- MEDLINE
DCOM- 20230112
LR  - 20240415
IS  - 1432-1912 (Electronic)
IS  - 0028-1298 (Linking)
VI  - 396
IP  - 2
DP  - 2023 Feb
TI  - Anticancer potential of oroxylin A: from mechanistic insight to synergistic 
      perspectives.
PG  - 191-212
LID - 10.1007/s00210-022-02298-0 [doi]
AB  - Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has 
      been used in ethnomedicine already for centuries in treating various neoplastic 
      disorders. However, only recent molecular studies have revealed the different 
      mechanisms behind its action, demonstrating antiproliferative, anti-inflammatory, 
      and proapoptotic effects, restricting also the spread of cancer cells to distant 
      organs. A variety of cellular targets and modulated signal transduction pathways 
      regulated by OA have been determined in diverse cells derived from different 
      malignant tissues. In this review article, these anticancer activities are 
      thoroughly described, representing OA as a potential lead structure for the 
      design of novel more potent anticancer medicines. In addition, co-effects of this 
      natural compound with conventional anticancer agents are analyzed and the 
      advantages provided by nanotechnological methods for more efficient application 
      of OA are discussed. In this way, OA might represent an excellent example of 
      using ethnopharmacological knowledge for designing modern medicines.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Tuli, Hardeep Singh
AU  - Tuli HS
AD  - Department of Biotechnology, Maharishi Markandeshwar Engineering College, 
      Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala, Haryana, 
      133207, India. hardeep.biotech@gmail.com.
FAU - Garg, Vivek Kumar
AU  - Garg VK
AD  - Department of Medical Laboratory Technology, University Institute of Applied 
      Health Sciences, Chandigarh University, Gharuan, Mohali, 140413, Punjab, India.
FAU - Kumar, Ajay
AU  - Kumar A
AD  - Department of Botanical and Environmental Sciences, Guru Nanak Dev University, 
      Amritsar , 143005, Punjab, India.
FAU - Aggarwal, Diwakar
AU  - Aggarwal D
AD  - Department of Biotechnology, Maharishi Markandeshwar Engineering College, 
      Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala, Haryana, 
      133207, India.
FAU - Anand, Uttpal
AU  - Anand U
AD  - Department of Life Sciences, Ben-Gurion University of the Negev, 84105, 
      Beer-Sheva, Israel.
FAU - Parashar, Nidarshana Chaturvedi
AU  - Parashar NC
AD  - Department of Biotechnology, Maharishi Markandeshwar Engineering College, 
      Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala, Haryana, 
      133207, India.
FAU - Saini, Adesh K
AU  - Saini AK
AD  - Department of Biotechnology, Maharishi Markandeshwar Engineering College, 
      Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala, Haryana, 
      133207, India.
FAU - Mohapatra, Ranjan K
AU  - Mohapatra RK
AD  - Department of Chemistry, Government College of Engineering, Keonjhar, 758002, 
      Odisha, India.
FAU - Dhama, Kuldeep
AU  - Dhama K
AD  - Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar 
      Pradesh, 243122, India.
FAU - Kumar, Manoj
AU  - Kumar M
AD  - Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala 
      134007, Haryana, India.
FAU - Singh, Tejveer
AU  - Singh T
AD  - School of Life Science, Jawaharlal Nehru University, New Delhi, India.
FAU - Kaur, Jagjit
AU  - Kaur J
AD  - Graduate School of Biomedical Engineering, ARC Centre of Excellence in Nanoscale 
      Biophotonics (CNBP), Faculty of Engineering, The University of New South Wales, 
      Sydney, 2052, Australia.
FAU - Sak, Katrin
AU  - Sak K
AD  - NGO Praeventio, 50407, Tartu, Estonia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20221010
PL  - Germany
TA  - Naunyn Schmiedebergs Arch Pharmacol
JT  - Naunyn-Schmiedeberg's archives of pharmacology
JID - 0326264
RN  - 53K24Z586G (5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one)
RN  - 0 (Flavonoids)
RN  - 0 (Antineoplastic Agents)
SB  - IM
EIN - Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr 15;:. PMID: 38619590
MH  - *Flavonoids/pharmacology/therapeutic use
MH  - *Antineoplastic Agents/pharmacology/therapeutic use
MH  - Signal Transduction
MH  - Cell Line, Tumor
OTO - NOTNLM
OT  - Anti-inflammatory
OT  - Anti-neoplastic
OT  - Cancer
OT  - Flavonoids
OT  - Oroxylin-A
EDAT- 2022/10/11 06:00
MHDA- 2023/01/13 06:00
CRDT- 2022/10/10 11:14
PHST- 2022/07/01 00:00 [received]
PHST- 2022/09/20 00:00 [accepted]
PHST- 2022/10/11 06:00 [pubmed]
PHST- 2023/01/13 06:00 [medline]
PHST- 2022/10/10 11:14 [entrez]
AID - 10.1007/s00210-022-02298-0 [pii]
AID - 10.1007/s00210-022-02298-0 [doi]
PST - ppublish
SO  - Naunyn Schmiedebergs Arch Pharmacol. 2023 Feb;396(2):191-212. doi: 
      10.1007/s00210-022-02298-0. Epub 2022 Oct 10.