PMID- 36215573
OWN - NLM
STAT- MEDLINE
DCOM- 20230203
LR  - 20230303
IS  - 1535-5667 (Electronic)
IS  - 0161-5505 (Linking)
VI  - 64
IP  - 2
DP  - 2023 Feb
TI  - Fetal Dose from PET and CT in Pregnant Patients.
PG  - 312-319
LID - 10.2967/jnumed.122.263959 [doi]
AB  - When pregnancy is discovered during or after a diagnostic examination, the 
      physician or the patient may request an estimate of the radiation dose received 
      by the fetus as per guidelines and standard operating procedures. This study 
      provided the imaging community with dose estimates to the fetus from PET/CT with 
      protocols that are adapted to University of Michigan low-dose protocols for 
      patients known to be pregnant. Methods: There were 9 patients analyzed with data 
      for the first, second, and third trimesters, the availability of which is quite 
      rare. These images were used to calculate the size-specific dose estimate (SSDE) 
      from the CT scan portion and the SUV and (18)F-FDG uptake dose from the PET scan 
      portion using the MIRD formulation. The fetal dose estimates were tested for 
      correlation with each of the following independent measures: gestational age, 
      fetal volume, average water-equivalent diameter of the patient along the length 
      of the fetus, SSDE, SUV, and percentage of dose from (18)F-FDG. Stepwise multiple 
      linear regression analysis was performed to assess the partial correlation of 
      each variable. To our knowledge, this was the first study to determine fetal 
      doses from CT and PET images. Results: Fetal self-doses from (18)F for the first, 
      second, and third trimesters were 2.18 mGy (single data point), 0.74-1.82 mGy, 
      and 0.017-0.0017 mGy, respectively. The combined SSDE and fetal self-dose ranged 
      from 1.2 to 8.2 mGy. These types of images from pregnant patients are rare. 
      Conclusion: Our data indicate that the fetal radiation exposure from (18)F-FDG 
      PET and CT performed, when medically necessary, on pregnant women with cancer is 
      low. All efforts should be made to minimize fetal radiation exposure by modifying 
      the protocol.
CI  - (c) 2023 by the Society of Nuclear Medicine and Molecular Imaging.
FAU - Burton, Christiane Sarah
AU  - Burton CS
AD  - St. Jude Children's Research Hospital, Memphis, Tennessee; 
      christiane.burton@stjude.org.
FAU - Frey, Kirk
AU  - Frey K
AD  - Michigan Medicine, Ann Arbor, Michigan.
FAU - Fahey, Frederic
AU  - Fahey F
AD  - Children's Hospital, Boston, Massachusetts.
FAU - Kaminski, Mark S
AU  - Kaminski MS
AD  - University of Michigan, Ann Arbor, Michigan; and.
FAU - Brown, Richard K J
AU  - Brown RKJ
AD  - University of Utah School of Medicine, Salt Lake City, Utah.
FAU - Pohlen, Judith M
AU  - Pohlen JM
AD  - Michigan Medicine, Ann Arbor, Michigan.
FAU - Shulkin, Barry L
AU  - Shulkin BL
AD  - St. Jude Children's Research Hospital, Memphis, Tennessee.
LA  - eng
PT  - Journal Article
DEP - 20220908
PL  - United States
TA  - J Nucl Med
JT  - Journal of nuclear medicine : official publication, Society of Nuclear Medicine
JID - 0217410
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Humans
MH  - Female
MH  - Pregnancy
MH  - *Positron Emission Tomography Computed Tomography
MH  - *Fluorodeoxyglucose F18
MH  - Positron-Emission Tomography/adverse effects/methods
MH  - Fetus/diagnostic imaging
MH  - Tomography, X-Ray Computed/methods
MH  - Radiation Dosage
OTO - NOTNLM
OT  - MIRD
OT  - PET
OT  - PET/CT
OT  - fetal dose
OT  - imaging
OT  - radiation physics
EDAT- 2022/10/11 06:00
MHDA- 2023/02/04 06:00
CRDT- 2022/10/10 15:23
PHST- 2022/02/02 00:00 [received]
PHST- 2022/08/23 00:00 [revised]
PHST- 2022/10/11 06:00 [pubmed]
PHST- 2023/02/04 06:00 [medline]
PHST- 2022/10/10 15:23 [entrez]
AID - jnumed.122.263959 [pii]
AID - 10.2967/jnumed.122.263959 [doi]
PST - ppublish
SO  - J Nucl Med. 2023 Feb;64(2):312-319. doi: 10.2967/jnumed.122.263959. Epub 2022 Sep 
      8.