PMID- 36217617
OWN - NLM
STAT- MEDLINE
DCOM- 20221012
LR  - 20221207
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 11
IP  - 9
DP  - 2022 Sep
TI  - Peripheral white blood cell subtypes and the development/progression of diabetic 
      macular edema in type 2 diabetic patients: a comparative study.
PG  - 2887-2896
LID - 10.21037/apm-22-962 [doi]
AB  - BACKGROUND: Inflammation and immune dysregulation are involved in the 
      pathogenesis of diabetic macular edema (DME). The progressive increase of 
      neutrophils in peripheral blood can lead to the increase of the number of 
      neutrophils in the retina, thus leading to the sustained damage of the retinal 
      vascular system and the destruction of the blood retinal barrier (BRB); 
      lymphocytes play a protective role in vascular diseases caused by type 2 diabetes 
      mellitus (T2DM). The purpose of this study was to study the relationship between 
      the changes of leukocytes and their classification in peripheral blood and the 
      occurrence and progression of DME in patients with T2DM. METHODS: A retrospective 
      analysis was made on 81 patients with T2DM with DME (DME group) hospitalized in 
      our hospital from January 2019 to December 2020. According to the morphological 
      characteristics of macular edema in optical coherence tomography (OCT), they were 
      divided into early DME group (n=33) and late DME group (n=48); 33 patients with 
      diabetes retinopathy (DR) but without DME matched in age and course of disease 
      served as the control group (NO-DME group). The clinical parameters assessed 
      included eye examination, OCT results, WBCs and subtypes, blood glucose, and 
      glycosylated hemoglobin. RESULTS: Compared with NO-DME group (n=33), Neutrophils% 
      in DME group (n=81) was higher (57.37+/-9.52 vs. 63.27+/-7.85; P=0.001); Monocyte% 
      (7.63+/-1.77 vs. 6.88+/-1.83; P=0.047) and lymphocyte% (30.35+/-9.51 vs. 27.26+/-6.59; 
      P=0.032) were decreased. The optimal model was obtained with R 4.0.5 software. 
      With other relevant variables being the same, females had a significantly 
      increased risk of DME (b=1.273, P=0.015), %neutrophils was significantly 
      associated with increased risk of DME (b=0.152, P=0.0006), and %lymphocytes was 
      significantly associated with a reduced risk of DME (b=-0.027, P=0.179). However, 
      in the early and late DME groups, no significant differences in biological 
      markers were found, and a high-quality model was not obtained. CONCLUSIONS: In 
      this preliminary study, %neutrophils is associated with increased risk of DME, 
      whereas %lymphocytes is associated with a reduced risk of DME.
FAU - Zhu, Yan
AU  - Zhu Y
AD  - Ophthalmology Department, Nantong First People's Hospital, Nantong, China.
FAU - Xu, Mudong
AU  - Xu M
AD  - Ophthalmology Department, Nantong First People's Hospital, Nantong, China.
FAU - Li, Junnan
AU  - Li J
AD  - Ophthalmology Department, Nantong First People's Hospital, Nantong, China.
FAU - Li, Junjie
AU  - Li J
AD  - Ophthalmology Department, Nantong First People's Hospital, Nantong, China.
FAU - Li, Lele
AU  - Li L
AD  - Ophthalmology Department, Nantong First People's Hospital, Nantong, China.
FAU - Zhou, Yue
AU  - Zhou Y
AD  - Ophthalmology Department, Nantong First People's Hospital, Nantong, China.
FAU - Song, Yu
AU  - Song Y
AD  - Ophthalmology Department, Nantong First People's Hospital, Nantong, China.
FAU - Cai, Qi
AU  - Cai Q
AD  - Ophthalmology Department, Nantong First People's Hospital, Nantong, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Biomarkers
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Retinopathy
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Leukocytes
MH  - *Macular Edema/complications/diagnosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - %lymphocytes
OT  - %neutrophils
OT  - Diabetic macular edema (DME)
OT  - optical coherence tomography (OCT)
OT  - white blood cells (WBC)
EDAT- 2022/10/12 06:00
MHDA- 2022/10/13 06:00
CRDT- 2022/10/11 02:23
PHST- 2022/06/28 00:00 [received]
PHST- 2022/09/08 00:00 [accepted]
PHST- 2022/10/11 02:23 [entrez]
PHST- 2022/10/12 06:00 [pubmed]
PHST- 2022/10/13 06:00 [medline]
AID - 10.21037/apm-22-962 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2022 Sep;11(9):2887-2896. doi: 10.21037/apm-22-962.