PMID- 36217832
OWN - NLM
STAT- MEDLINE
DCOM- 20221125
LR  - 20221125
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 34
IP  - 47
DP  - 2022 Nov
TI  - Direct Presentation of Tumor-Associated Antigens to Induce Adaptive Immunity by 
      Personalized Dendritic Cell-Mimicking Nanovaccines.
PG  - e2205950
LID - 10.1002/adma.202205950 [doi]
AB  - Dendritic cells (DCs)-based vaccines are an approved method for inducing potent 
      antigen-specific immune responses to eliminate tumor cells. However, this 
      promising strategy still faces challenges such as tumor-associated antigens 
      (TAAs) loading, lymph node homing, quality control, and other limitations. Here, 
      a personalized DC-mimicking nanovaccine (nanoDC) for stimulation of TAAs-specific 
      T cell populations is developed. The nanoDCs are fabricated using nanoparticles 
      with dendritic structure and membranes from mature bone-marrow-derived cells 
      (BMDCs). Mature BMDCs are stimulated by nanostructures assembled from Escherichia 
      coli and tumor cells to efficiently deliver TAAs and induce BMDCs maturation 
      through the stimulator of interferon genes (STING) pathway. By maintaining 
      co-stimulatory markers, molecules class I (MHC-I) antigen complexes and 
      lymphocyte homing receptors, nanoDCs efficiently migrate to lymph nodes and 
      generate potent antigen-specific T cell responses. Consequently, vaccination with 
      nanoDCs strongly inhibits the tumor growth and metastases formation in vivo. In 
      particular, nanoDCs can also induce memory T cells for long-term protective 
      immunity. This study demonstrates that nanoDCs can trigger adaptive immune 
      protection against tumors for personalized immunotherapy and precision medicine.
CI  - (c) 2022 Wiley-VCH GmbH.
FAU - Zhang, Jie
AU  - Zhang J
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology, Beijing, 100190, P. R. China.
AD  - University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
FAU - Fan, Biao
AU  - Fan B
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology, Beijing, 100190, P. R. China.
FAU - Cao, Guoliang
AU  - Cao G
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology, Beijing, 100190, P. R. China.
FAU - Huang, Wenping
AU  - Huang W
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology, Beijing, 100190, P. R. China.
AD  - University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
FAU - Jia, Fuhao
AU  - Jia F
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology, Beijing, 100190, P. R. China.
AD  - University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
FAU - Nie, Guangjun
AU  - Nie G
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology, Beijing, 100190, P. R. China.
AD  - University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
FAU - Wang, Hai
AU  - Wang H
AUID- ORCID: 0000-0002-1292-998X
AD  - CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS 
      Center for Excellence in Nanoscience, National Center for Nanoscience and 
      Technology, Beijing, 100190, P. R. China.
AD  - University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
LA  - eng
GR  - XDB36000000/Strategic Priority Research Program of Chinese Academy of Sciences/
GR  - 31971307/National Natural Science Foundation of China/
GR  - Start-Up Foundation of National Center for Nanoscience and Technology/
PT  - Journal Article
DEP - 20221018
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
RN  - 0 (Antigens, Neoplasm)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Dendritic Cells
MH  - Antigens, Neoplasm
MH  - Immunotherapy/methods
MH  - *Neoplasms
MH  - Adaptive Immunity
MH  - Mice, Inbred C57BL
OTO - NOTNLM
OT  - antigen presentation
OT  - cancer immunotherapy
OT  - dendritic cell
OT  - personalized vaccine
EDAT- 2022/10/12 06:00
MHDA- 2022/11/26 06:00
CRDT- 2022/10/11 04:03
PHST- 2022/10/01 00:00 [revised]
PHST- 2022/06/30 00:00 [received]
PHST- 2022/10/12 06:00 [pubmed]
PHST- 2022/11/26 06:00 [medline]
PHST- 2022/10/11 04:03 [entrez]
AID - 10.1002/adma.202205950 [doi]
PST - ppublish
SO  - Adv Mater. 2022 Nov;34(47):e2205950. doi: 10.1002/adma.202205950. Epub 2022 Oct 
      18.