PMID- 36220403
OWN - NLM
STAT- MEDLINE
DCOM- 20221111
LR  - 20221111
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 222
IP  - Pt B
DP  - 2022 Dec 1
TI  - The polysaccharides from the fruits of Lycium barbarum L. modify the gut 
      community profile and alleviate dextran sulfate sodium-induced colitis in mice.
PG  - 2244-2257
LID - S0141-8130(22)02247-4 [pii]
LID - 10.1016/j.ijbiomac.2022.10.015 [doi]
AB  - In the present study, the effects of a purified fraction of polysaccharides from 
      the fruits of Lycium barbarum L. (LBPs), named LBPs-4, on the dextran sodium 
      sulfate (DSS)-induced colitis in mice were evaluated. The results showed that 
      LBPs-4 decreased disease activity index score, prevented colon shortening and 
      reduced plasma levels of pro-inflammatory cytokines (tumor necrosis factor alpha 
      (TNF-alpha), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and 
      prostaglandin E2) in mice with colitis. LBPs-4 could increase the relative 
      abundances of Akkermansia and Bifidobacterium in gut microbiota, and it also 
      mitigated the intestinal barrier damage by upregulating the level of tight 
      junction protein ZO-1 and the number of goblet cells in colon. Moreover, the 
      results of in vitro culture indicated that the growth of Bifidobacterium longum 
      subsp. infantis CCX 19042 was promoted by LBPs-4, whereas the culture media of 
      LBPs-4 by Bacteroides ovatus with or without addition of mucin could enhance the 
      growth of Akkermansia muciniphila. Collectively, these results suggested that 
      LBPs-4 should be potential prebiotics for the treatment of colitis.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Zhou, Wangting
AU  - Zhou W
AD  - College of Food Science and Technology, Nanjing Agricultural University, Nanjing 
      210095, Jiangsu, China.
FAU - Kan, Xuhui
AU  - Kan X
AD  - College of Food Science and Technology, Nanjing Agricultural University, Nanjing 
      210095, Jiangsu, China.
FAU - Chen, Guijie
AU  - Chen G
AD  - College of Food Science and Technology, Nanjing Agricultural University, Nanjing 
      210095, Jiangsu, China.
FAU - Sun, Yi
AU  - Sun Y
AD  - College of Food Science and Technology, Nanjing Agricultural University, Nanjing 
      210095, Jiangsu, China.
FAU - Ran, Linwu
AU  - Ran L
AD  - Laboratory Animal Center of Ningxia Medical University, Yinchuan 750004, Ningxia, 
      China.
FAU - Yan, Yamei
AU  - Yan Y
AD  - Institute of Wolfberry Engineering and Technology, Ningxia Academy of Agriculture 
      and Forestry, Yinchuan 750004, Ningxia, China.
FAU - Mi, Jia
AU  - Mi J
AD  - Institute of Wolfberry Engineering and Technology, Ningxia Academy of Agriculture 
      and Forestry, Yinchuan 750004, Ningxia, China.
FAU - Lu, Lu
AU  - Lu L
AD  - Institute of Wolfberry Engineering and Technology, Ningxia Academy of Agriculture 
      and Forestry, Yinchuan 750004, Ningxia, China.
FAU - Zeng, Xiaoxiong
AU  - Zeng X
AD  - College of Food Science and Technology, Nanjing Agricultural University, Nanjing 
      210095, Jiangsu, China. Electronic address: zengxx@njau.edu.cn.
FAU - Cao, Youlong
AU  - Cao Y
AD  - Institute of Wolfberry Engineering and Technology, Ningxia Academy of Agriculture 
      and Forestry, Yinchuan 750004, Ningxia, China. Electronic address: 
      youlongck@126.com.
LA  - eng
PT  - Journal Article
DEP - 20221008
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 9042-14-2 (Dextran Sulfate)
RN  - 0 (Polysaccharides)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Lycium
MH  - Dextran Sulfate/adverse effects
MH  - Fruit
MH  - *Colitis/chemically induced/drug therapy/microbiology
MH  - Polysaccharides/adverse effects
MH  - Colon
MH  - Mice, Inbred C57BL
MH  - Disease Models, Animal
OTO - NOTNLM
OT  - Akkermansia muciniphila
OT  - Bifidobacterium longum subsp.infantis
OT  - Colitis
OT  - Gut microbiota
OT  - Lycium barbarum L.
OT  - Polysaccharides
COIS- Declaration of competing interest The authors have declared that there is no 
      conflict of interest.
EDAT- 2022/10/12 06:00
MHDA- 2022/11/15 06:00
CRDT- 2022/10/11 21:45
PHST- 2022/07/28 00:00 [received]
PHST- 2022/09/11 00:00 [revised]
PHST- 2022/10/03 00:00 [accepted]
PHST- 2022/10/12 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/10/11 21:45 [entrez]
AID - S0141-8130(22)02247-4 [pii]
AID - 10.1016/j.ijbiomac.2022.10.015 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2022 Dec 1;222(Pt B):2244-2257. doi: 
      10.1016/j.ijbiomac.2022.10.015. Epub 2022 Oct 8.