PMID- 36220436 OWN - NLM STAT- MEDLINE DCOM- 20221025 LR - 20230411 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 309 IP - Pt 2 DP - 2022 Dec TI - Association of serum per- and polyfluoroalkyl substances and gestational anemia during different trimesters in Zhuang ethnic pregnancy women of Guangxi, China. PG - 136798 LID - S0045-6535(22)03291-X [pii] LID - 10.1016/j.chemosphere.2022.136798 [doi] AB - BACKGROUND: Gestational anemia is a complication of pregnancy, and a low level of hemoglobin (Hb) has been linked to adverse pregnancy outcomes. Previous studies reported that PFASs were more strongly associated with Hb than red blood cells, indicating that Hb is more susceptible to the effect of PFASs. However, the evidences regarding the effects of per- and polyfluoroalkyl substances (PFASs) on gestational anemia are currently limited. Therefore, it is important to explore the effects of PFASs on anemia in Chinese pregnant women. METHODS: A total of 821 pregnant women were recruited between June 2015 and April 2019 in the Guangxi Zhuang Birth Cohort. The concentrations of PFASs were assessed in maternal serum before 12 gestational weeks. To determine both individual and combined associations of PFASs exposure with anemia in the three stages of pregnancy, binary logistic regression, Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) regression models were employed. RESULTS: In single-pollutant analysis, maternal exposure to perfluorododecanoic acid (PFDoA) and perfluoroheptanoic acid (PFHpA) were associated with anemia in the first trimester, exposure to PFHpA and perfluorobutanesulfonic acid (PFBS) were associated with anemia in the second trimester, and exposure to perfluorodecanoic acid (PFDA) and perfluorononanoic acid (PFNA) were associated with anemia in the third trimester. Notably, perfluoroundecanoic acid (PFUnA) had a nonlinear association with anemia in the third trimester. In multiple-pollutant analysis, a positive association of PFDoA with anemia in the first trimester and a negative association of PFBS with anemia in the second trimester were confirmed by BKMR. Exposure to PFASs mixture was not associated with anemia in all three trimesters. In WQS, there was a significantly negative association between the PFAS mixture and anemia in the second trimester. CONCLUSION: Maternal exposure to PFASs is associated with gestational anemia in different trimesters. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Liao, Qian AU - Liao Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Tang, Peng AU - Tang P AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Pan, Dongxiang AU - Pan D AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Song, Yanye AU - Song Y AD - The Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, Guangxi, China. FAU - Lei, Lei AU - Lei L AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Liang, Jun AU - Liang J AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Liu, Bihu AU - Liu B AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Lin, Mengrui AU - Lin M AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Huang, Huishen AU - Huang H AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Mo, Meile AU - Mo M AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Huang, Chengtuo AU - Huang C AD - Department of Physical Examination, Guangxi Tiandong Hospital of Traditional Chinese Medicine, Tiandong, 531500, Guangxi, China. FAU - Wei, Ming AU - Wei M AD - Department of Obstetrics and Gynecology, Child Hygiene, Maternal and Child Health Care Hospital of Tianyang District, Baise City, 542899, Guangxi, China. FAU - Liu, Shun AU - Liu S AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. Electronic address: liushun@gxmu.edu.cn. FAU - Huang, Dongping AU - Huang D AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. Electronic address: dongpinghuang@gxmu.edu.cn. FAU - Qiu, Xiaoqiang AU - Qiu X AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. Electronic address: xqqiu9999@163.com. LA - eng PT - Journal Article DEP - 20221008 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (perfluorobutanesulfonic acid) RN - 0 (Fluorocarbons) RN - 0 (Environmental Pollutants) SB - IM EIN - Chemosphere. 2023 Jul;329:138640. PMID: 37040672 MH - Humans MH - Female MH - Pregnancy MH - *Fluorocarbons MH - Pregnant Women MH - Bayes Theorem MH - China/epidemiology MH - *Environmental Pollutants/toxicity MH - Pregnancy Outcome MH - *Anemia/chemically induced/epidemiology OTO - NOTNLM OT - Gestational anemia OT - Gestational week OT - Hemoglobin OT - Joint effect OT - Per- and polyfluoroalkyl substance COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/10/12 06:00 MHDA- 2022/10/26 06:00 CRDT- 2022/10/11 21:45 PHST- 2022/07/02 00:00 [received] PHST- 2022/10/04 00:00 [revised] PHST- 2022/10/05 00:00 [accepted] PHST- 2022/10/12 06:00 [pubmed] PHST- 2022/10/26 06:00 [medline] PHST- 2022/10/11 21:45 [entrez] AID - S0045-6535(22)03291-X [pii] AID - 10.1016/j.chemosphere.2022.136798 [doi] PST - ppublish SO - Chemosphere. 2022 Dec;309(Pt 2):136798. doi: 10.1016/j.chemosphere.2022.136798. Epub 2022 Oct 8.