PMID- 36220523
OWN - NLM
STAT- MEDLINE
DCOM- 20221101
LR  - 20221103
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 190
DP  - 2022 Nov
TI  - Dynamic inflammatory changes of the neurovascular units after ischemic stroke.
PG  - 140-151
LID - S0361-9230(22)00272-6 [pii]
LID - 10.1016/j.brainresbull.2022.10.003 [doi]
AB  - Ischemic stroke (IS) is an acute brain injury and a major cause of disability and 
      mortality worldwide, resulting from permanent or temporary cerebral artery 
      occlusion. Thrombolysis and antithrombotic therapy or thrombectomy over a wider 
      therapeutic window led to reduced stroke mortality. However, the post-stroke 
      pathological mechanism is still elusive, involving sustaining inflammation and 
      cellular dysfunction, which hinders the recovery after IS. Thus, more attention 
      is shifting towards the complex interactions of the neurovascular unit (NVU) and 
      its important role in the progress of inflammation recently. This review 
      summarized the physiological function of each component of the NVU and their 
      functions on blood brain barrier permeability, cerebral blood flow regulation and 
      the inflammation progress after IS. In addition, we described the 
      inflammation-related pathological changes affected by the NVU and concluded that 
      the dysfunction of the NVU contributed to the inflammation progress after IS. 
      This review may provide ideas for the potential therapies targeting the NVU for 
      improving the prognosis of IS.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Meng, Jieyi
AU  - Meng J
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Peking University, Beijing 100191, China.
FAU - Zhang, Jiayi
AU  - Zhang J
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Peking University, Beijing 100191, China.
FAU - Fang, Jinyu
AU  - Fang J
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Peking University, Beijing 100191, China.
FAU - Li, Man
AU  - Li M
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Peking University, Beijing 100191, China.
FAU - Ding, Huiru
AU  - Ding H
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Peking University, Beijing 100191, China.
FAU - Zhang, Weiguang
AU  - Zhang W
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Peking University, Beijing 100191, China.
FAU - Chen, Chunhua
AU  - Chen C
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Peking University, Beijing 100191, China. Electronic address: 
      cch@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20221008
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
SB  - IM
MH  - Humans
MH  - *Ischemic Stroke
MH  - Brain/pathology
MH  - *Stroke/pathology
MH  - Blood-Brain Barrier/pathology
MH  - Inflammation/pathology
MH  - *Brain Ischemia
OTO - NOTNLM
OT  - Blood brain barrier
OT  - Inflammation
OT  - Ischemic stroke
OT  - Neurovascular unit
COIS- Conflict of interest disclosure The authors declare that they have no conflict of 
      interest.
EDAT- 2022/10/12 06:00
MHDA- 2022/11/02 06:00
CRDT- 2022/10/11 21:47
PHST- 2022/03/02 00:00 [received]
PHST- 2022/07/21 00:00 [revised]
PHST- 2022/10/04 00:00 [accepted]
PHST- 2022/10/12 06:00 [pubmed]
PHST- 2022/11/02 06:00 [medline]
PHST- 2022/10/11 21:47 [entrez]
AID - S0361-9230(22)00272-6 [pii]
AID - 10.1016/j.brainresbull.2022.10.003 [doi]
PST - ppublish
SO  - Brain Res Bull. 2022 Nov;190:140-151. doi: 10.1016/j.brainresbull.2022.10.003. 
      Epub 2022 Oct 8.