PMID- 36220617 OWN - NLM STAT- MEDLINE DCOM- 20221206 LR - 20221206 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 170 DP - 2022 Dec TI - Exposure to a mixture of personal care product and plasticizing chemicals in relation to reproductive hormones and menarche timing among 12-19 years old girls in NHANES 2013-2016. PG - 113463 LID - S0278-6915(22)00661-5 [pii] LID - 10.1016/j.fct.2022.113463 [doi] AB - The effects of co-exposure to personal care product and plasticizing chemicals (PCPPCs) on reproductive hormones and menarche timing has rarely been studied. We used Bayesian kernel machine regression (BKMR), adaptive least absolute shrinkage and selection operator (adaptive LASSO), and generalized linear model (GLM) to explore the mixture effects of 16 PCPPCs on reproductive hormones and early menarche among 297 girls aged 12-19 years in the National Health and Nutrition Examination Survey (NHANES) 2013-2016. In the BKMR, the mixture of PCPPCs was negatively and positively associated with testosterone (TT) and sex hormone-binding globulin (SHBG), respectively. In the adaptive LASSO, 2,5-dichlorophenol (2, 5-DCP), Mono (carboxyisoctyl) phthalate (MCOP), and Mono-benzyl phthalate (MBzP) were positively associated with estrogen (E2), whereas Mono-ethyl phthalate (MEP), Monoisobutyl phthalate (MiBP) and Mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) were inversely associated with E2. Bisphenol A (BPA) and MBzP were positively associated with SHBG, whereas Mono (carboxyisonony) phthalate (MCNP) and Mono (2-ethyl-5-carboxypentyl) phthalate (MECPP) were inversely associated with SHBG. In GLM, Benzophenone-3 (BZP) and MECPP were negatively associated with TT, whereas 2,4-dichlorophenol (2,4-DCP) revealed a positive association with early menarche onset. In conclusion, PCPPCs in the mixture and individually are associated with reproductive hormones and early menarche onset in girls. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Bigambo, Francis Manyori AU - Bigambo FM AD - State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. FAU - Zhang, Mingzhi AU - Zhang M AD - State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. FAU - Zhang, Jie AU - Zhang J AD - Department of Toxicology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China. FAU - Yang, Xu AU - Yang X AD - State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. FAU - Yu, Qiurun AU - Yu Q AD - State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. FAU - Wu, Di AU - Wu D AD - State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. FAU - Wang, Xu AU - Wang X AD - Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. Electronic address: sepnine@njmu.edu.cn. FAU - Xia, Yankai AU - Xia Y AD - State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. Electronic address: yankaixia@njmu.edu.cn. LA - eng PT - Journal Article DEP - 20221008 PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 RN - 6O7F7IX66E (phthalic acid) RN - 0 (Phthalic Acids) RN - 27NM8BNV1K (mono-benzyl phthalate) RN - 0 (Cosmetics) RN - 3XMK78S47O (Testosterone) RN - 0 (Environmental Pollutants) SB - IM MH - Female MH - Humans MH - Child MH - Adolescent MH - Young Adult MH - Adult MH - Nutrition Surveys MH - Menarche MH - Bayes Theorem MH - *Phthalic Acids MH - *Cosmetics MH - Testosterone MH - *Environmental Pollutants/analysis MH - Environmental Exposure/analysis OTO - NOTNLM OT - Adaptive LASSO regression OT - Bayesian kernel machine regression (BKMR) OT - Early menarche OT - Generalized linear model (GLM) OT - Mixture of PCPPCs OT - Reproductive hormone COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/10/12 06:00 MHDA- 2022/12/07 06:00 CRDT- 2022/10/11 21:49 PHST- 2022/03/09 00:00 [received] PHST- 2022/08/15 00:00 [revised] PHST- 2022/10/04 00:00 [accepted] PHST- 2022/10/12 06:00 [pubmed] PHST- 2022/12/07 06:00 [medline] PHST- 2022/10/11 21:49 [entrez] AID - S0278-6915(22)00661-5 [pii] AID - 10.1016/j.fct.2022.113463 [doi] PST - ppublish SO - Food Chem Toxicol. 2022 Dec;170:113463. doi: 10.1016/j.fct.2022.113463. Epub 2022 Oct 8.