PMID- 36223019
OWN - NLM
STAT- MEDLINE
DCOM- 20230216
LR  - 20230216
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 7
DP  - 2023 Feb
TI  - Importance of surface charge of soot nanoparticles in determining inhalation 
      toxicity in mice.
PG  - 18985-18997
LID - 10.1007/s11356-022-23444-4 [doi]
AB  - Physicochemical properties of nanoparticles are important in regulating 
      nanoparticle toxicity; however, the contribution of nanoparticle charge remains 
      unclear. The objective of this study was to investigate the pulmonary effects of 
      inhalation of charged soot nanoparticles. We established a stably charged 
      nanoparticle generation system for whole-body exposure in BALB/c mice, which 
      produced positively charged, negatively charged, and neutral soot nanoparticles 
      in a wide range of concentrations. After a 7-day exposure, pulmonary toxicity was 
      assessed, together with proteomics analysis. The charged soot nanoparticles on 
      average carried 1.17-1.35 electric charges, and the sizes for nanoparticles under 
      different charging conditions were all fixed at 69 ~ 72 nm. We observed that 
      charged soot nanoparticles induced cytotoxic LDH and increased lung permeability, 
      with the release of 8-isoprostane and caspase-3 and systemic IL-6 in mice, 
      especially for positively charged soot nanoparticles. Next, we observed that 
      positive-charged soot nanoparticles upregulated Eif2, Eif4, sirtuin, mammalian 
      target of rapamycin (mTOR), peroxisome proliferator-activated receptors (PPAR), 
      and HIPPO-related signaling pathways in the lungs compared with negatively 
      charged soot nanoparticles. HIF1alpha, sirt1, E-cadherin, and Yap were increased in 
      mice's lungs by positively charged soot nanoparticle exposure. In conclusion, 
      carbonaceous nanoparticles carrying electric ions, especially positive-charged, 
      are particularly toxic when inhaled and should be of concern in terms of 
      pulmonary health protection.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Hsiao, Ta-Chih
AU  - Hsiao TC
AD  - Graduate Institute of Environmental Engineering, National Taiwan University, 
      Taipei, Taiwan.
FAU - Han, Chia-Li
AU  - Han CL
AD  - Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei 
      Medical University, Taipei, Taiwan.
FAU - Yang, Tzu-Ting
AU  - Yang TT
AD  - Department of Environmental Engineering and Health, Yuanpei University of Medical 
      Technology, Hsin Chu City, Taiwan.
FAU - Lee, Yueh-Lun
AU  - Lee YL
AD  - Department of Microbiology and Immunology, School of Medicine, College of 
      Medicine, Taipei Medical University, Taipei, Taiwan.
FAU - Shen, Yu-Fang
AU  - Shen YF
AD  - Graduate Institute of Environmental Engineering, National Center University, 
      Tauyoun, Taiwan.
FAU - Jheng, Yu-Teng
AU  - Jheng YT
AD  - Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan 
      University, Taipei, Taiwan.
FAU - Lee, Chii-Hong
AU  - Lee CH
AD  - Department of Pathology, Taipei City Hospital Heping Fuyou Branch, Taipei, 
      Taiwan.
FAU - Chang, Jer-Hwa
AU  - Chang JH
AD  - School of Respiratory Therapy, College of Medicine, Taipei Medical University, 
      Taipei, Taiwan.
AD  - Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang 
      Hospital, Taipei Medical University, Taipei, Taiwan.
FAU - Chung, Kian Fan
AU  - Chung KF
AD  - National Heart and Lung Institute, Imperial College London, London, UK.
FAU - Kuo, Han-Pin
AU  - Kuo HP
AD  - Division of Pulmonary Medicine, Department of Internal Medicine, School of 
      Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
FAU - Chuang, Hsiao-Chi
AU  - Chuang HC
AUID- ORCID: 0000-0003-4651-5192
AD  - Department of Pathology, Taipei City Hospital Heping Fuyou Branch, Taipei, 
      Taiwan. chuanghc@tmu.edu.tw.
AD  - Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho 
      Hospital, Taipei Medical University, New Taipei City, Taiwan. 
      chuanghc@tmu.edu.tw.
AD  - Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei 
      Medical University, Taipei, Taiwan. chuanghc@tmu.edu.tw.
LA  - eng
GR  - 109-2314-B-038-093-MY3/Ministry of Science and Technology, Taiwan/
PT  - Journal Article
DEP - 20221012
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Soot)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Soot/chemistry
MH  - Lung
MH  - *Nanoparticles/toxicity/chemistry
MH  - Administration, Inhalation
MH  - Mammals
OTO - NOTNLM
OT  - Inflammation
OT  - Nanoparticle charge
OT  - Nanoparticles
OT  - Oxidative stress
OT  - Particulate matter
OT  - Polycyclic aromatic hydrocarbons
EDAT- 2022/10/13 06:00
MHDA- 2023/02/17 06:00
CRDT- 2022/10/12 11:19
PHST- 2022/07/19 00:00 [received]
PHST- 2022/09/30 00:00 [accepted]
PHST- 2022/10/13 06:00 [pubmed]
PHST- 2023/02/17 06:00 [medline]
PHST- 2022/10/12 11:19 [entrez]
AID - 10.1007/s11356-022-23444-4 [pii]
AID - 10.1007/s11356-022-23444-4 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Feb;30(7):18985-18997. doi: 
      10.1007/s11356-022-23444-4. Epub 2022 Oct 12.