PMID- 3622379
OWN - NLM
STAT- MEDLINE
DCOM- 19870928
LR  - 20131121
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 121
IP  - 3
DP  - 1987 Sep
TI  - 17 Beta-estradiol inhibits the oxidative metabolism of U937 cells indirectly via 
      lymphocytes.
PG  - 853-7
AB  - The effect of 17 beta-estradiol (E) on the oxidative metabolism of U937 cells was 
      studied. E had no direct effect on the proliferation, surface adherence, or 
      luminol-enhanced luminescence (LEL) of the U937 cells. Exposure of U937 cells to 
      lymphocyte-conditioned medium (LCM) and 1,25-dihydroxyvitamin D3 allowed a 
      maximal LEL response by cells stimulated with phorbol myristate acetate. In 
      contrast, LCM from lymphocytes exposed to E (LCM-E) did not stimulate LEL to the 
      same extent as did an equal volume of LCM. Increasing the E concentration in the 
      lymphocyte medium was associated with a dose-dependent reduction in the LEL 
      response of the U937 cells. Mixing equal quantities of LCM and LCM-E 
      significantly decreased LEL levels. LEL stimulated by LCM, gamma-interferon, or 
      differentiation-inducing factor was reduced by the presence of LCM-E. The 
      inhibitory action of LCM-E was reversible and metabolite specific. 17 alpha-E 
      produced an effect that was only one tenth the magnitude of the E effect. These 
      findings indicate that E can modulate the differentiation of phagocytes 
      indirectly by altering the synthesis and/or secretion of lymphokines.
FAU - Sivam, G
AU  - Sivam G
FAU - Cohen, M S
AU  - Cohen MS
FAU - Dodd, R C
AU  - Dodd RC
FAU - Gray, T K
AU  - Gray TK
LA  - eng
GR  - R01-AM-33320-03/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Culture Media)
RN  - 0 (Lymphokines)
RN  - 0 (Pyridazines)
RN  - 4TI98Z838E (Estradiol)
RN  - 5EXP385Q4F (Luminol)
RN  - FXC9231JVH (Calcitriol)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Calcitriol/pharmacology
MH  - Cell Differentiation/drug effects
MH  - Cell Line
MH  - Culture Media
MH  - Estradiol/*pharmacology
MH  - Humans
MH  - *Luminescent Measurements
MH  - Luminol/*pharmacology
MH  - Lymphocytes/drug effects/*physiology
MH  - Lymphokines/pharmacology
MH  - Oxidation-Reduction
MH  - Pyridazines/*pharmacology
MH  - Tetradecanoylphorbol Acetate
EDAT- 1987/09/01 00:00
MHDA- 1987/09/01 00:01
CRDT- 1987/09/01 00:00
PHST- 1987/09/01 00:00 [pubmed]
PHST- 1987/09/01 00:01 [medline]
PHST- 1987/09/01 00:00 [entrez]
AID - 10.1210/endo-121-3-853 [doi]
PST - ppublish
SO  - Endocrinology. 1987 Sep;121(3):853-7. doi: 10.1210/endo-121-3-853.