PMID- 36224003
OWN - NLM
STAT- MEDLINE
DCOM- 20221014
LR  - 20221028
IS  - 2768-6698 (Electronic)
IS  - 2768-6698 (Linking)
VI  - 27
IP  - 9
DP  - 2022 Aug 31
TI  - FDXR Gene Expression after in Vivo Radiation Exposure of Pediatric Patients 
      Undergoing Interventional Cardiology Procedures.
PG  - 255
LID - 10.31083/j.fbl2709255 [doi]
AB  - BACKGROUND: Ferredoxin reductase (FDXR) has already been reported as a promising 
      biomarker for estimating radiation doses in radiotherapy. This study aimed to 
      investigate the responsiveness of FDXR on pediatric population exposed to 
      ionizing radiation (X-rays) during pediatric interventional cardiology (IC) 
      procedures. PATIENTS AND METHODS: Peripheral blood was collected by venipuncture 
      from 24 pediatric donors before and 24 hours after the IC procedure. To estimate 
      the effective dose, demographic data and Air Kerma-Area Product (PKA) were 
      recorded for each patient. The relative quantification (RQ) of the FDXR gene in 
      irradiated patient blood samples compared to the non-irradiated blood samples was 
      determined using qPCR analysis. The relative values of FDXR were log- 
      transformed. RESULTS: The effective dose ranged from 0.002 mSv to 8.004 mSv. Over 
      this radiation exposure range, the FDXR gene expression varied randomly with the 
      effective dose. Up-regulation in FDXR expression was observed in 17 patients and 
      down-regulation in 7 patients. CONCLUSIONS: Further studies in a larger cohort of 
      pediatric patients along with the record of clinical data are needed to determine 
      whether FDXR gene expression is an effective biomarker for radiation exposure 
      estimation in pediatric imaging.
CI  - (c) 2022 The Author(s). Published by IMR Press.
FAU - Spyratou, Ellas
AU  - Spyratou E
AD  - 2nd Department of Radiology, Medical School, National and Kapodistrian University 
      of Athens, 11527 Athens, Greece.
FAU - Ploussi, Agapi
AU  - Ploussi A
AD  - 2nd Department of Radiology, Medical School, National and Kapodistrian University 
      of Athens, 11527 Athens, Greece.
FAU - Alafogiannis, Panagiotis
AU  - Alafogiannis P
AD  - Physics Department, School of Applied Mathematical and Physical Sciences, 
      National Technical University of Athens, 15780 Zografou, Athens, Greece.
FAU - Katifelis, Hector
AU  - Katifelis H
AD  - Department of Basic Medical Sciences, Laboratory of Biology, Medical School, 
      National and Kapodistrian University of Athens, 11527 Athens, Greece.
FAU - Apostolopoulou, Sotiria
AU  - Apostolopoulou S
AD  - Paediatric Cardiology and Adult with Congenital Heart Disease Department, Onassis 
      Cardiac Surgery Center, 17674 Athens, Greece.
FAU - Bagenakis, Georgios
AU  - Bagenakis G
AD  - Paediatric Cardiology and Adult with Congenital Heart Disease Department, Onassis 
      Cardiac Surgery Center, 17674 Athens, Greece.
FAU - Rammos, Spyridon
AU  - Rammos S
AD  - Paediatric Cardiology and Adult with Congenital Heart Disease Department, Onassis 
      Cardiac Surgery Center, 17674 Athens, Greece.
FAU - Papagiannis, Ioannis
AU  - Papagiannis I
AD  - Paediatric Cardiology and Adult with Congenital Heart Disease Department, Onassis 
      Cardiac Surgery Center, 17674 Athens, Greece.
FAU - Gazouli, Maria
AU  - Gazouli M
AD  - Department of Basic Medical Sciences, Laboratory of Biology, Medical School, 
      National and Kapodistrian University of Athens, 11527 Athens, Greece.
AD  - Department of Medical Physics, Medical School, National and Kapodistrian 
      University, 11527 Athens, Greece.
AD  - Department of Sciences, Hellenic Open University, 26335 Patra, Greece.
FAU - Seimenis, Ioannis
AU  - Seimenis I
AD  - Department of Medical Physics, Medical School, National and Kapodistrian 
      University, 11527 Athens, Greece.
FAU - Georgakilas, Alexandros G
AU  - Georgakilas AG
AD  - DNA Damage Laboratory, Department of Physics, School of Applied Mathematical and 
      Physical Sciences, Zografou Campus, National Technical University of Athens 
      (NTUA), 15780 Athens, Greece.
FAU - Efstathopoulos, Efstathios P
AU  - Efstathopoulos EP
AD  - 2nd Department of Radiology, Medical School, National and Kapodistrian University 
      of Athens, 11527 Athens, Greece.
AD  - Department of Sciences, Hellenic Open University, 26335 Patra, Greece.
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Front Biosci (Landmark Ed)
JT  - Frontiers in bioscience (Landmark edition)
JID - 101612996
RN  - 0 (Biomarkers)
RN  - 0 (Ferredoxins)
RN  - EC 1.- (Oxidoreductases)
SB  - IM
MH  - Biomarkers
MH  - *Cardiology
MH  - Child
MH  - Ferredoxins
MH  - Gene Expression
MH  - Humans
MH  - Oxidoreductases
MH  - *Radiation Exposure/adverse effects
OTO - NOTNLM
OT  - FDXR gene
OT  - ionizing radiation
OT  - pediatric interventional cardiology
COIS- The authors declare no conflict of interest. AGG is serving as one of the 
      Editorial Board members/Guest editors of this journal. We declare that AGG had no 
      involvement in the peer review of this article and has no access to information 
      regarding its peer review. Full responsibility for the editorial process for this 
      article was delegated to Taeg Kyu Kwon.
EDAT- 2022/10/13 06:00
MHDA- 2022/10/15 06:00
CRDT- 2022/10/12 21:30
PHST- 2022/06/12 00:00 [received]
PHST- 2022/07/19 00:00 [revised]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/10/12 21:30 [entrez]
PHST- 2022/10/13 06:00 [pubmed]
PHST- 2022/10/15 06:00 [medline]
AID - S2768-6701(22)00599-8 [pii]
AID - 10.31083/j.fbl2709255 [doi]
PST - ppublish
SO  - Front Biosci (Landmark Ed). 2022 Aug 31;27(9):255. doi: 10.31083/j.fbl2709255.