PMID- 36225301
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221014
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 13
DP  - 2022
TI  - Sex differences during a cold-stress test in normobaric and hypobaric hypoxia: A 
      randomized controlled crossover study.
PG  - 998665
LID - 10.3389/fphys.2022.998665 [doi]
LID - 998665
AB  - Cold and hypoxia are two stressors that are frequently combined and investigated 
      in the scientific literature. Despite the growing literature regarding normobaric 
      hypoxia (NH) and hypobaric hypoxia (HH), responses between females and males are 
      less often evaluated. Therefore, this study aims to investigate the physiological 
      sex differences following a cold-stress test under normoxia, normobaric- and 
      hypobaric hypoxia. A total of n = 10 females (24.8 +/- 5.1 years) and n = 10 males 
      (30.3 +/- 6.3 years) from a university population volunteered for this study. The 
      cold-stress test (CST) of the right hand (15 degrees C for 2 min) was performed using a 
      randomised crossover design in normobaric normoxia, NH and HH. The change (∆) 
      from baseline to post-CST up to 15 min was analysed for cutaneous vascular 
      conductance (CVC) and the hands' skin temperature, whilst the mean values across 
      time (post-CST up to 15 min) were assessed for peripheral oxygen saturation 
      (SpO(2)), thermal sensation- and comfort. Pressure pain threshold (PPT) was 
      assessed after the post-CST 15 min period. The hands' skin temperature drop was 
      higher (p = 0.01) in the female group (∆3.3 +/- 1.5 degrees C) compared to the male group 
      (∆1.9 +/- 0.9 degrees C) only in NH. Females (-0.9 +/- 0.5) rated this temperature drop in NH 
      to feel significantly colder (p = 0.02) compared to the males (-0.2 +/- 0.7). No 
      differences were observed between sexes in NN, NH, and HH for ∆CVC, SpO(2), 
      thermal comfort and PPT. In conclusion, females and males show similar reactions 
      after a CST under normoxia and hypoxia. Sex differences were observed in the 
      local skin temperature response and thermal sensation only in NH.
CI  - Copyright (c) 2022 Hohenauer, Taube, Freitag and Clijsen.
FAU - Hohenauer, Erich
AU  - Hohenauer E
AD  - Rehabilitation and Exercise Science Laboratory (RES lab), Department of Business 
      Economics, Health and Social Care, University of Applied Sciences and Arts of 
      Southern Switzerland, Landquart, Switzerland.
AD  - Department of Physiotherapy, International University of Applied Sciences THIM, 
      Landquart, Switzerland.
AD  - Department of Neurosciences and Movement Science, University of Fribourg, 
      Fribourg, Switzerland.
AD  - Department of Movement and Sport Sciences, Vrije Universiteit Brussel, Brussels, 
      Belgium.
FAU - Taube, Wolfgang
AU  - Taube W
AD  - Department of Neurosciences and Movement Science, University of Fribourg, 
      Fribourg, Switzerland.
FAU - Freitag, Livia
AU  - Freitag L
AD  - Rehabilitation and Exercise Science Laboratory (RES lab), Department of Business 
      Economics, Health and Social Care, University of Applied Sciences and Arts of 
      Southern Switzerland, Landquart, Switzerland.
FAU - Clijsen, Ron
AU  - Clijsen R
AD  - Rehabilitation and Exercise Science Laboratory (RES lab), Department of Business 
      Economics, Health and Social Care, University of Applied Sciences and Arts of 
      Southern Switzerland, Landquart, Switzerland.
AD  - Department of Physiotherapy, International University of Applied Sciences THIM, 
      Landquart, Switzerland.
AD  - Department of Movement and Sport Sciences, Vrije Universiteit Brussel, Brussels, 
      Belgium.
AD  - Department of Health, Bern University of Applied Sciences, Berne, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20220923
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC9549379
OTO - NOTNLM
OT  - cold
OT  - cold and hypoxia
OT  - hypoxia
OT  - physiology
OT  - sex difference
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/14 06:00
MHDA- 2022/10/14 06:01
PMCR- 2022/09/23
CRDT- 2022/10/13 02:27
PHST- 2022/07/20 00:00 [received]
PHST- 2022/09/05 00:00 [accepted]
PHST- 2022/10/13 02:27 [entrez]
PHST- 2022/10/14 06:00 [pubmed]
PHST- 2022/10/14 06:01 [medline]
PHST- 2022/09/23 00:00 [pmc-release]
AID - 998665 [pii]
AID - 10.3389/fphys.2022.998665 [doi]
PST - epublish
SO  - Front Physiol. 2022 Sep 23;13:998665. doi: 10.3389/fphys.2022.998665. eCollection 
      2022.