PMID- 36225875
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221014
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Association of healthy lifestyles on the risk of hypertension, type 2 diabetes 
      mellitus, and their comorbidity among subjects with dyslipidemia.
PG  - 1006379
LID - 10.3389/fnut.2022.1006379 [doi]
LID - 1006379
AB  - BACKGROUND: Adherence to a healthy lifestyle could reduce the risk of 
      hypertension and diabetes in general populations; however, whether the 
      associations exist in subjects with dyslipidemia remains unclear. This study 
      aimed to investigate the integrated effect of lifestyle factors on the risk of 
      hypertension, type 2 diabetes mellitus (T2DM), and their comorbidity among 
      subjects with dyslipidemia. METHODS: In total of 9,339 subjects with dyslipidemia 
      were recruited from the baseline survey of the Guangzhou Heart Study. A 
      questionnaire survey and medical examination were performed. The healthy 
      lifestyle score (HLS) was derived from five factors: smoking, alcohol drinking, 
      diet, body mass index, and leisure-time physical activity. Odds ratios (ORs) with 
      95% confidence interval (95% CI) were calculated by using the logistic regression 
      model and the multinomial logistic regression after adjusting for confounders. 
      RESULTS: The prevalence of hypertension, T2DM, and their comorbidity was 47.65, 
      16.02, and 10.10%, respectively. Subjects with a higher HLS were associated with 
      a lower risk of hypertension, T2DM, and their comorbidity. In comparison to the 
      subjects with 0-2 HLS, the adjusted ORs for subjects with five HLS was 0.48 (95% 
      CI: 0.40-0.57) and 0.67 (95% CI: 0.54-0.84) for hypertension and T2DM. Compared 
      with subjects with 0-2 HLS and neither hypertension nor T2DM, those with five HLS 
      had a lower risk of suffering from only one disease (OR: 0.48, 95% CI: 0.40-0.57) 
      and their comorbidity (OR: 0.35, 95% CI: 0.26-0.47). CONCLUSIONS: The results 
      suggest that the more kinds of healthy lifestyle, the lower the risk of 
      hypertension, T2DM, and their comorbidity among subjects with dyslipidemia. 
      Preventive strategies incorporating lifestyle factors may provide a more feasible 
      approach for the prevention of main chronic diseases.
CI  - Copyright (c) 2022 Hu, Zheng, Duan, Zhou, Huang, Lao, Zhao, Li, Xue, Zhao, Deng and 
      Liu.
FAU - Hu, Peng
AU  - Hu P
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
AD  - Department of Epidemiology, School of Public Health, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Zheng, Murui
AU  - Zheng M
AD  - Department of Community Health, Guangzhou Center for Disease Control and 
      Prevention, Guangzhou, China.
FAU - Duan, Xueru
AU  - Duan X
AD  - Department of Epidemiology, School of Public Health, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Zhou, Huanning
AU  - Zhou H
AD  - Department of Chronic Disease, Guangzhou Yuexiu District Center for Disease 
      Control and Prevention, Guangzhou, China.
FAU - Huang, Jun
AU  - Huang J
AD  - Department of Geriatrics, Institute of Geriatrics, Guangdong Provincial People's 
      Hospital, Guangdong Academy of Medical Science, Guangzhou, China.
FAU - Lao, Lixian
AU  - Lao L
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Science, Guangzhou, 
      China.
FAU - Zhao, Yue
AU  - Zhao Y
AD  - Department of Epidemiology, School of Public Health, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Li, Yi
AU  - Li Y
AD  - Department of Epidemiology, School of Public Health, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Xue, Meng
AU  - Xue M
AD  - Department of Epidemiology, School of Public Health, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Zhao, Wenjing
AU  - Zhao W
AD  - School of Public Health and Emergency Management, Southern University of Science 
      and Technology, Shenzhen, China.
FAU - Deng, Hai
AU  - Deng H
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Science, Guangzhou, 
      China.
FAU - Liu, Xudong
AU  - Liu X
AD  - School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220926
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9550234
OTO - NOTNLM
OT  - comorbidity
OT  - diabetes
OT  - hypertension
OT  - lifestyle
OT  - subjects with dyslipidemia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/14 06:00
MHDA- 2022/10/14 06:01
PMCR- 2022/01/01
CRDT- 2022/10/13 02:40
PHST- 2022/07/29 00:00 [received]
PHST- 2022/09/09 00:00 [accepted]
PHST- 2022/10/13 02:40 [entrez]
PHST- 2022/10/14 06:00 [pubmed]
PHST- 2022/10/14 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.1006379 [doi]
PST - epublish
SO  - Front Nutr. 2022 Sep 26;9:1006379. doi: 10.3389/fnut.2022.1006379. eCollection 
      2022.