PMID- 36225916
OWN - NLM
STAT- MEDLINE
DCOM- 20221014
LR  - 20221017
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Case Report: Immune reconstitution inflammatory syndrome after hematopoietic stem 
      cell transplantation for severe combined immunodeficiency.
PG  - 960749
LID - 10.3389/fimmu.2022.960749 [doi]
LID - 960749
AB  - We report a case of immune reconstitution inflammatory syndrome (IRIS) after 
      hematopoietic stem cell transplantation (HSCT). The patient had sever bacillus 
      Calmette-Guerin (BCG) vaccine-caused disseminated infection and had received 
      allogeneic HSCT for X-linked severe combined immunodeficiency disease. After 
      HSCT, complicated by treatment-responding veno-occlusive disease and acute 
      graft-versus-host disease, at the time when immunosuppressants were withdrawn, 
      the patient experienced recurrent fever accompanied by elevated inflammatory 
      indicators. After receiving glucocorticoids and ibuprofen, the patient's 
      condition improved, and a diagnosis with BCG-related IRIS was made.
CI  - Copyright (c) 2022 Liu, Huo, Dai, Wu, Qin, Mao and Wang.
FAU - Liu, Shuangjun
AU  - Liu S
AD  - Beijing Children's Hospital, Capital Medical University, Beijing, China.
FAU - Huo, Feng
AU  - Huo F
AD  - Beijing Children's Hospital, Capital Medical University, Beijing, China.
FAU - Dai, Guorui
AU  - Dai G
AD  - Beijing Children's Hospital, Capital Medical University, Beijing, China.
FAU - Wu, Jie
AU  - Wu J
AD  - Beijing Children's Hospital, Capital Medical University, Beijing, China.
FAU - Qin, Maoquan
AU  - Qin M
AD  - Beijing Children's Hospital, Capital Medical University, Beijing, China.
FAU - Mao, Huawei
AU  - Mao H
AD  - Beijing Children's Hospital, Capital Medical University, Beijing, China.
FAU - Wang, Quan
AU  - Wang Q
AD  - Beijing Children's Hospital, Capital Medical University, Beijing, China.
LA  - eng
PT  - Case Reports
DEP - 20220926
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (BCG Vaccine)
RN  - 0 (Immunosuppressive Agents)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - BCG Vaccine/adverse effects
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - Ibuprofen
MH  - *Immune Reconstitution Inflammatory Syndrome/diagnosis/etiology
MH  - Immunosuppressive Agents
MH  - *Severe Combined Immunodeficiency
PMC - PMC9548620
OTO - NOTNLM
OT  - BCG disseminated tuberculosis
OT  - HSCT = hematopoietic stem cell transplant
OT  - IL2RG
OT  - IRIS - immune reconstitution inflammatory syndrome
OT  - severe combined immunodeficiency
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/14 06:00
MHDA- 2022/10/15 06:00
PMCR- 2022/01/01
CRDT- 2022/10/13 02:41
PHST- 2022/06/03 00:00 [received]
PHST- 2022/09/06 00:00 [accepted]
PHST- 2022/10/13 02:41 [entrez]
PHST- 2022/10/14 06:00 [pubmed]
PHST- 2022/10/15 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.960749 [doi]
PST - epublish
SO  - Front Immunol. 2022 Sep 26;13:960749. doi: 10.3389/fimmu.2022.960749. eCollection 
      2022.