PMID- 36226334
OWN - NLM
STAT- MEDLINE
DCOM- 20230721
LR  - 20230724
IS  - 1943-572X (Electronic)
IS  - 0003-4894 (Print)
IS  - 0003-4894 (Linking)
VI  - 132
IP  - 9
DP  - 2023 Sep
TI  - Clinical Predictors of Symptom Improvement Following Eustachian Tube Balloon 
      Dilation.
PG  - 1032-1039
LID - 10.1177/00034894221129912 [doi]
AB  - OBJECTIVE: This study aims to identify clinical predictors of treatment response 
      to Eustachian Tube Balloon Dilation (ETBD) as measured by changes in Eustachian 
      Tube Dysfunction Questionnaire-7 (ETDQ-7) scores. METHODS: One hundred thirteen 
      patients who underwent ETBD at an institution from 2017 to 2021 completed ETDQ-7 
      pre- and post-operatively. We conducted multivariable regression analyses with 
      ETDQ-7 normalization (<2.1 post-op), minimum clinically important difference 
      (MCID) (>0.5 pre-op - post-op), and quantitative improvement in ETDQ-7 score as 
      outcome variables. Pre-operative ETDQ-7 score, tympanogram type, chronic otitis 
      media, chronic rhinosinusitis (CRS), inferior turbinate hypertrophy, deviated 
      septum, allergic rhinitis, and rhinorrhea were included as covariates. Models 
      controlled for age, sex, ethnicity, prior ear or sinus surgery, and follow-up 
      duration. RESULTS: The mean age was 49 years old. 51% were females, and all 
      patients had pre-operative ETDQ-7 above 2.1. After a mean follow-up period of 
      13 months, 77% achieved MCID and 37% had normalized. Higher pre-operative ETDQ-7 
      score was associated with greater ETDQ-7 score improvement (B = 0.60, 95% 
      CI = [0.37, 0.83]) and greater odds of achieving MCID (aOR = 1.65; 95% 
      CI = [1.06, 2.59]). A history of CRS improved chances of achieving MCID 
      (aOR = 4.53; 95% CI = [1.11, 18.55]) and a history of chronic otitis media 
      predicted increased odds of ETDQ-7 normalization (aOR = 2.88; 95% CI = [1.09, 
      7.58]). CONCLUSIONS: Our findings suggest that ETBD was highly effective among 
      patients with pre-operative ETDQ-7 above 2.1. Furthermore, higher pre-operative 
      ETDQ-7 score, CRS, and chronic otitis media predicted more favorable symptomatic 
      benefit from ETBD. These factors may be important to consider when counseling 
      potential candidates for this procedure.
FAU - Yang, Hong-Ho
AU  - Yang HH
AUID- ORCID: 0000-0003-2032-3141
AD  - Department of Head and Neck Surgery, David Geffen School of Medicine at 
      University of California, Los Angeles, Los Angeles, CA, USA.
FAU - Alonso, Jose
AU  - Alonso J
AD  - Department of Head and Neck Surgery, David Geffen School of Medicine at 
      University of California, Los Angeles, Los Angeles, CA, USA.
FAU - Ishiyama, Akira
AU  - Ishiyama A
AD  - Department of Head and Neck Surgery, David Geffen School of Medicine at 
      University of California, Los Angeles, Los Angeles, CA, USA.
FAU - Gopen, Quinton S
AU  - Gopen QS
AD  - Department of Head and Neck Surgery, David Geffen School of Medicine at 
      University of California, Los Angeles, Los Angeles, CA, USA.
FAU - Suh, Jeffrey D
AU  - Suh JD
AD  - Department of Head and Neck Surgery, David Geffen School of Medicine at 
      University of California, Los Angeles, Los Angeles, CA, USA.
FAU - Wang, Marilene B
AU  - Wang MB
AD  - Department of Head and Neck Surgery, David Geffen School of Medicine at 
      University of California, Los Angeles, Los Angeles, CA, USA.
FAU - Wells, Christine
AU  - Wells C
AD  - Office of Advanced Research and Computing, University of California, Los Angeles, 
      Los Angeles, CA, USA.
FAU - Wung, Vivian
AU  - Wung V
AD  - Department of Head and Neck Surgery, David Geffen School of Medicine at 
      University of California, Los Angeles, Los Angeles, CA, USA.
FAU - Lee, Jivianne T
AU  - Lee JT
AD  - Department of Head and Neck Surgery, David Geffen School of Medicine at 
      University of California, Los Angeles, Los Angeles, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20221012
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
SB  - IM
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Male
MH  - *Eustachian Tube/surgery
MH  - Dilatation/methods
MH  - Hearing Tests
MH  - *Sinusitis/diagnosis/therapy/complications
MH  - Endoscopy
MH  - *Ear Diseases/diagnosis/therapy
MH  - Chronic Disease
MH  - Treatment Outcome
PMC - PMC10359951
OTO - NOTNLM
OT  - ETDQ-7
OT  - Eustachian tube
OT  - Eustachian tube balloon dilation
OT  - chronic rhinosinusitis
OT  - otitis media
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2022/10/14 06:00
MHDA- 2023/07/21 06:43
PMCR- 2023/07/21
CRDT- 2022/10/13 02:55
PHST- 2023/07/21 06:43 [medline]
PHST- 2022/10/14 06:00 [pubmed]
PHST- 2022/10/13 02:55 [entrez]
PHST- 2023/07/21 00:00 [pmc-release]
AID - 10.1177_00034894221129912 [pii]
AID - 10.1177/00034894221129912 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2023 Sep;132(9):1032-1039. doi: 
      10.1177/00034894221129912. Epub 2022 Oct 12.