PMID- 36227848
OWN - NLM
STAT- MEDLINE
DCOM- 20230202
LR  - 20230215
IS  - 1535-4989 (Electronic)
IS  - 1044-1549 (Linking)
VI  - 68
IP  - 2
DP  - 2023 Feb
TI  - Adenovirus-mediated Overexpression of FcgammaRIIB Attenuates Pulmonary Inflammation 
      and Fibrosis.
PG  - 213-227
LID - 10.1165/rcmb.2022-0056OC [doi]
AB  - Progressive fibrosing interstitial lung diseases (PF-ILDs) result in high 
      mortality and lack effective therapies. The pathogenesis of PF-ILDs involves 
      macrophages driving inflammation and irreversible fibrosis. Fc-gamma receptors 
      (FcgammaRs) regulate macrophages and inflammation, but their roles in PF-ILDs remain 
      unclear. We characterized the expression of FcgammaRs and found upregulated FcgammaRIIB 
      in human and mouse lungs after exposure to silica. FcgammaRIIB deficiency aggravated 
      lung dysfunction, inflammation, and fibrosis in silica-exposed mice. Using 
      single-cell transcriptomics and in vitro experiments, FcgammaRIIB was found in 
      alveolar macrophages, where it regulated the expression of fibrosis-related genes 
      Spp1 and Ctss. In mice with macrophage-specific overexpression of FcgammaRIIB and in 
      mice treated with adenovirus by intratracheal instillation to upregulate FcgammaRIIB, 
      silica-induced functional and histological changes were ameliorated. Our data 
      from three genetic models and a therapeutic model suggest that FcgammaRIIB plays a 
      protective role that can be enhanced by adenoviral overexpression, representing a 
      potential therapeutic strategy for PF-ILDs.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - Department of Pulmonary and Critical Care Medicine, The First Hospital of Shanxi 
      Medical University, Taiyuan, China.
AD  - Department of Physiology and.
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
AD  - National Health Commission Key Laboratory of Pneumoconiosis, Taiyuan, China.
FAU - Cao, Zhujie
AU  - Cao Z
AD  - Department of Physiology and.
FAU - Hou, Lin
AU  - Hou L
AD  - Department of Physiology and.
FAU - Song, Meiyue
AU  - Song M
AD  - Department of Physiology and.
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
FAU - Zhou, Yitian
AU  - Zhou Y
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
FAU - Chen, Yiling
AU  - Chen Y
AD  - Department of Physiology and.
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Xi'an Jiao tong University, Xi'an, China; and.
FAU - Hu, Huiyuan
AU  - Hu H
AD  - Department of Physiology and.
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Xi'an Jiao tong University, Xi'an, China; and.
FAU - Hou, Yangfeng
AU  - Hou Y
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - Department of Physiology and.
FAU - Li, Bolun
AU  - Li B
AD  - Department of Physiology and.
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
FAU - Song, Xiaomin
AU  - Song X
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
FAU - Ge, Weipeng
AU  - Ge W
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
FAU - Li, Baicun
AU  - Li B
AD  - Department of Physiology and.
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
AD  - Department of Pulmonary and Critical Care Medicine, Center of Respiratory 
      Medicine, China-Japan Friendship Hospital, Beijing, China.
FAU - Jiang, Xuehan
AU  - Jiang X
AD  - Department of Physiology and.
FAU - Yang, Jie
AU  - Yang J
AD  - Department of Physiology and.
FAU - Song, Dingyun
AU  - Song D
AD  - Department of Pulmonary and Critical Care Medicine, Center of Respiratory 
      Medicine, China-Japan Friendship Hospital, Beijing, China.
FAU - Zhang, Xinri
AU  - Zhang X
AD  - Department of Pulmonary and Critical Care Medicine, The First Hospital of Shanxi 
      Medical University, Taiyuan, China.
AD  - National Health Commission Key Laboratory of Pneumoconiosis, Taiyuan, China.
FAU - Pang, Junling
AU  - Pang J
AD  - Department of Physiology and.
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
FAU - Zhang, Tiantian
AU  - Zhang T
AD  - Department of Physiology and.
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
FAU - Zhang, Hong
AU  - Zhang H
AD  - Department of Physiology and.
FAU - Yang, Peiran
AU  - Yang P
AUID- ORCID: 0000-0002-4635-1215
AD  - Department of Physiology and.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Pulmonary and Critical Care Medicine, The First Hospital of Shanxi 
      Medical University, Taiyuan, China.
AD  - Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, 
      Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking 
      Union Medical College, Beijing, China.
FAU - Wang, Chen
AU  - Wang C
AD  - Department of Pulmonary and Critical Care Medicine, The First Hospital of Shanxi 
      Medical University, Taiyuan, China.
AD  - Department of Physiology and.
AD  - National Health Commission Key Laboratory of Pneumoconiosis, Taiyuan, China.
AD  - Department of Pulmonary and Critical Care Medicine, Center of Respiratory 
      Medicine, China-Japan Friendship Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Cell Mol Biol
JT  - American journal of respiratory cell and molecular biology
JID - 8917225
RN  - 0 (Receptors, IgG)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
CIN - Am J Respir Cell Mol Biol. 2023 Feb;68(2):129-130. PMID: 36315436
MH  - Humans
MH  - Animals
MH  - Mice
MH  - Adenoviridae/genetics/metabolism
MH  - *Pneumonia/genetics
MH  - Inflammation/genetics/metabolism
MH  - Receptors, IgG/genetics/metabolism
MH  - *Lung Diseases, Interstitial
MH  - Fibrosis
MH  - Silicon Dioxide
OTO - NOTNLM
OT  - FcgammaRIIB
OT  - Spp1
OT  - macrophages
OT  - pulmonary fibrosis
OT  - pulmonary function
EDAT- 2022/10/14 06:00
MHDA- 2023/02/03 06:00
CRDT- 2022/10/13 13:34
PHST- 2022/10/14 06:00 [pubmed]
PHST- 2023/02/03 06:00 [medline]
PHST- 2022/10/13 13:34 [entrez]
AID - 10.1165/rcmb.2022-0056OC [doi]
PST - ppublish
SO  - Am J Respir Cell Mol Biol. 2023 Feb;68(2):213-227. doi: 10.1165/rcmb.2022-0056OC.