PMID- 36231240
OWN - NLM
STAT- MEDLINE
DCOM- 20221017
LR  - 20230120
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 19
DP  - 2022 Sep 21
TI  - Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A 
      Systematic Review and Meta-Analysis.
LID - 10.3390/ijerph191911943 [doi]
LID - 11943
AB  - Oral health is an integral component of general health and well-being but might 
      be undermined among children living with HIV (CLWH) due to the condition itself 
      or the antiretroviral therapy (ART) received. This review summarises the current 
      evidence and compares the oral health status of the CLWH who were treatment-naive 
      with those undergoing different ART medications. Fourteen studies were included 
      in the final qualitative and quantitative analyses. This review identified no 
      significant difference in the prevalence of caries, periodontal conditions, and 
      tooth development between both groups. Orofacial opportunistic infections were 
      more prevalent in the CLWH without ART. Children undergoing ART with a duration 
      longer than 3 years had a significantly lower prevalence of oral candidiasis and 
      CD4+ T-cell counts. However, due to the insufficient number of well-administered 
      case-control studies with adequate sample size, the quality of the evidence in 
      all outcomes was of very low certainty.
FAU - Lam, Phoebe Pui Ying
AU  - Lam PPY
AD  - Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, 
      Pokfulam, Hong Kong.
FAU - Zhou, Ni
AU  - Zhou N
AD  - School of Stomatology, Kunming Medical University, Kunming 650032, China.
FAU - Yiu, Cynthia Kar Yung
AU  - Yiu CKY
AUID- ORCID: 0000-0003-4090-6205
AD  - Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, 
      Pokfulam, Hong Kong.
FAU - Wong, Hai Ming
AU  - Wong HM
AUID- ORCID: 0000-0003-3411-6442
AD  - Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, 
      Pokfulam, Hong Kong.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20220921
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - CD4 Lymphocyte Count
MH  - *Candidiasis, Oral
MH  - Child
MH  - *HIV Infections/complications/drug therapy/epidemiology
MH  - Humans
MH  - Oral Health
MH  - Prevalence
PMC - PMC9565507
OTO - NOTNLM
OT  - HIV
OT  - adolescents
OT  - antiretroviral therapy
OT  - children
OT  - meta-analysis
OT  - oral health
COIS- The authors declare no conflicts of interest.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/18 06:00
PMCR- 2022/09/21
CRDT- 2022/10/14 01:56
PHST- 2022/08/23 00:00 [received]
PHST- 2022/09/16 00:00 [revised]
PHST- 2022/09/19 00:00 [accepted]
PHST- 2022/10/14 01:56 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/18 06:00 [medline]
PHST- 2022/09/21 00:00 [pmc-release]
AID - ijerph191911943 [pii]
AID - ijerph-19-11943 [pii]
AID - 10.3390/ijerph191911943 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Sep 21;19(19):11943. doi: 
      10.3390/ijerph191911943.