PMID- 36231907
OWN - NLM
STAT- MEDLINE
DCOM- 20221017
LR  - 20230117
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 19
DP  - 2022 Oct 2
TI  - The Influence of HLA Alleles on the Affective Distress Profile.
LID - 10.3390/ijerph191912608 [doi]
LID - 12608
AB  - (1) Background: Affective distress can be triggered by aggressive stimuli with an 
      unfavorable role for the individual. Some of the factors that lead to the 
      development and evolution of a mental disorder can be genetic. The aim of this 
      study is to determine some correlations between the human leukocyte antigen (HLA) 
      genes and the affective distress profile (PDA). (2) Methods: A psychological 
      assessment and testing tool for anxiety was applied to 115 people. The 
      low-resolution HLA alleles of class I (HLA-A, HLA-B, and HLA-C) and class II 
      (HLA-DRB1 and HLA-DQB1) were identified by the PCR technique after DNA extraction 
      from the blood. Depending on the PDA, the subjects were divided into two groups: 
      a group with a low PDA and another one with a medium and high PDA. The IBM SPSS 
      software was used to compare the frequency of HLA alleles between the two groups. 
      (3) Results: The univariate analysis revealed a significant association of the 
      HLA-A locus (A*01, A*30), HLA-B (B*08), and HLA-DRB1 (DRB1*11) with the low PDA 
      group and of the HLA-A locus (A*32), HLA-B (B*52), and HLA-C (C*12) with the 
      medium and high PDA group. (4) Conclusions: The present study highlighted 
      potential associations between HLA alleles and anxiety disorders.
FAU - Vica, Mihaela Laura
AU  - Vica ML
AUID- ORCID: 0000-0003-0811-0821
AD  - Department of Cellular and Molecular Biology, "Iuliu Hatieganu" University of 
      Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
AD  - Institute of Legal Medicine, 400006 Cluj-Napoca, Romania.
FAU - Delcea, Cristian
AU  - Delcea C
AUID- ORCID: 0000-0003-0667-2898
AD  - Institute of Legal Medicine, 400006 Cluj-Napoca, Romania.
AD  - Faculty of Psychology, "Tibiscus" University, 300559 Timisoara, Romania.
AD  - Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 
      400012 Cluj-Napoca, Romania.
FAU - Dumitrel, Gabriela Alina
AU  - Dumitrel GA
AUID- ORCID: 0000-0002-2097-5230
AD  - Faculty of Industrial Chemistry and Environmental Engineering, Polytechnic 
      University, 300223 Timisoara, Romania.
FAU - Vuscan, Mihaela Elvira
AU  - Vuscan ME
AD  - Department of Cellular and Molecular Biology, "Iuliu Hatieganu" University of 
      Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
AD  - Institute of Legal Medicine, 400006 Cluj-Napoca, Romania.
FAU - Matei, Horea Vladi
AU  - Matei HV
AUID- ORCID: 0000-0003-2051-3973
AD  - Department of Cellular and Molecular Biology, "Iuliu Hatieganu" University of 
      Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
AD  - Institute of Legal Medicine, 400006 Cluj-Napoca, Romania.
FAU - Teodoru, Cosmin Adrian
AU  - Teodoru CA
AD  - Clinical Surgical Department, Faculty of Medicine, "Lucian Blaga" University, 
      550002 Sibiu, Romania.
FAU - Siserman, Costel Vasile
AU  - Siserman CV
AD  - Institute of Legal Medicine, 400006 Cluj-Napoca, Romania.
AD  - Department of Legal Medicine, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, 400012 Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
DEP - 20221002
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - DNA
MH  - Gene Frequency
MH  - *HLA-A Antigens/genetics
MH  - HLA-B Antigens
MH  - *HLA-C Antigens/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Humans
PMC - PMC9564508
OTO - NOTNLM
OT  - HLA
OT  - affective distress
OT  - anxiety
OT  - univariate analysis
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/18 06:00
PMCR- 2022/10/02
CRDT- 2022/10/14 02:02
PHST- 2022/09/10 00:00 [received]
PHST- 2022/09/26 00:00 [revised]
PHST- 2022/09/28 00:00 [accepted]
PHST- 2022/10/14 02:02 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/18 06:00 [medline]
PHST- 2022/10/02 00:00 [pmc-release]
AID - ijerph191912608 [pii]
AID - ijerph-19-12608 [pii]
AID - 10.3390/ijerph191912608 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Oct 2;19(19):12608. doi: 
      10.3390/ijerph191912608.