PMID- 36232165
OWN - NLM
STAT- MEDLINE
DCOM- 20221017
LR  - 20230113
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 19
DP  - 2022 Oct 8
TI  - Oral Health Status of Children and Adolescents Living with HIV Undergoing 
      Antiretroviral Therapy: A Systematic Review and Meta-Analysis.
LID - 10.3390/ijerph191912864 [doi]
LID - 12864
AB  - Antiretroviral therapy (ART) increases the survival of HIV-infected children, but 
      might also bring in oral health-related side effects and increase their risks of 
      oral diseases. The review compared the oral health status of children living with 
      HIV (CLWH) undergoing ART with healthy controls. Dual independent screening and 
      study selection from four electronic databases and manual searches, data 
      extraction, risk of bias assessment, and quality-of-evidence evaluation with 
      Grading of Recommendations Assessment Development and Evaluation were performed. 
      Twelve studies were included in qualitative and quantitative analysis. CLWH 
      taking ART had a significantly higher prevalence of periodontal diseases (OR = 
      3.11, 95% CI 1.62-5.97), mucosal hyperpigmentation (OR = 20.35, 95% CI 
      3.86-107.39), and orofacial-related opportunistic infections than healthy 
      controls. No significant differences regarding caries prevalence and tooth 
      development were identified. Those with CD4+ T-cell counts below 250 cells/mm(3) 
      were more likely to manifest opportunistic infections, while medication duration 
      had minimal influence on the prevalence of orofacial opportunistic infections. 
      The current findings did not identify HIV and antiretroviral status as 
      predisposing factors to dental caries, but affirmed the associated increased risk 
      of periodontal diseases, mucosal hyperpigmentation and candidiasis.
FAU - Lam, Phoebe Pui Ying
AU  - Lam PPY
AD  - Paediatric Dentistry, Faculty of Dentistry, the University of Hong Kong, 
      Pokfulam, Hong Kong SAR, China.
FAU - Zhou, Ni
AU  - Zhou N
AD  - School of Stomatology, Kunming Medical University, Kunming 650032, China.
FAU - Wong, Hai Ming
AU  - Wong HM
AUID- ORCID: 0000-0003-3411-6442
AD  - Paediatric Dentistry, Faculty of Dentistry, the University of Hong Kong, 
      Pokfulam, Hong Kong SAR, China.
FAU - Yiu, Cynthia Kar Yung
AU  - Yiu CKY
AUID- ORCID: 0000-0003-4090-6205
AD  - Paediatric Dentistry, Faculty of Dentistry, the University of Hong Kong, 
      Pokfulam, Hong Kong SAR, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20221008
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Dental Caries/epidemiology
MH  - *HIV Infections/complications/drug therapy/epidemiology
MH  - Humans
MH  - *Hyperpigmentation
MH  - *Opportunistic Infections
MH  - Oral Health
MH  - *Periodontal Diseases/epidemiology
PMC - PMC9564723
OTO - NOTNLM
OT  - HIV
OT  - antiretroviral therapy
OT  - children
OT  - meta-analysis
OT  - oral health
OT  - systematic review
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/18 06:00
PMCR- 2022/10/08
CRDT- 2022/10/14 02:04
PHST- 2022/08/16 00:00 [received]
PHST- 2022/09/28 00:00 [revised]
PHST- 2022/10/06 00:00 [accepted]
PHST- 2022/10/14 02:04 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/18 06:00 [medline]
PHST- 2022/10/08 00:00 [pmc-release]
AID - ijerph191912864 [pii]
AID - ijerph-19-12864 [pii]
AID - 10.3390/ijerph191912864 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Oct 8;19(19):12864. doi: 
      10.3390/ijerph191912864.