PMID- 36233311
OWN - NLM
STAT- MEDLINE
DCOM- 20221017
LR  - 20221019
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 19
DP  - 2022 Oct 9
TI  - Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a 
      Molecular to a Clinical Perspective.
LID - 10.3390/ijms231912010 [doi]
LID - 12010
AB  - The contribution of choroidal vasculature to the pathogenesis of age-related 
      macular degeneration (AMD) has been long debated. The present narrative review 
      aims to discuss the primary molecular and choroidal structural changes occurring 
      with aging and AMD with a brief overview of the principal multimodal imaging 
      modalities and techniques that enable the optimal in vivo visualization of 
      choroidal modifications. The molecular aspects that target the choroid in AMD 
      mainly involve human leukocyte antigen (HLA) expression, complement 
      dysregulation, leukocyte interaction at Bruch's membrane, and mast cell 
      infiltration of the choroid. A mechanistic link between high-risk genetic loci 
      for AMD and mast cell recruitment has also been recently demonstrated. Recent 
      advances in multimodal imaging allow more detailed visualization of choroidal 
      structure, identifying alterations that may expand our comprehension of aging and 
      AMD development.
FAU - Fragiotta, Serena
AU  - Fragiotta S
AUID- ORCID: 0000-0002-6214-6270
AD  - Department of Neurosciences, Mental Health and Sense Organs (NESMOS), 
      Ophthalmology Unit, St. Andrea Hospital, University of Rome "La Sapienza", 00189 
      Rome, Italy.
FAU - Scuderi, Luca
AU  - Scuderi L
AD  - Department of Sense Organs, University Sapienza of Rome, 00161 Rome, Italy.
FAU - Iodice, Clemente Maria
AU  - Iodice CM
AD  - Department of Neurosciences, Mental Health and Sense Organs (NESMOS), 
      Ophthalmology Unit, St. Andrea Hospital, University of Rome "La Sapienza", 00189 
      Rome, Italy.
FAU - Rullo, Daria
AU  - Rullo D
AD  - Department of Neurosciences, Mental Health and Sense Organs (NESMOS), 
      Ophthalmology Unit, St. Andrea Hospital, University of Rome "La Sapienza", 00189 
      Rome, Italy.
FAU - Di Pippo, Mariachiara
AU  - Di Pippo M
AUID- ORCID: 0000-0002-1089-2060
AD  - Department of Neurosciences, Mental Health and Sense Organs (NESMOS), 
      Ophthalmology Unit, St. Andrea Hospital, University of Rome "La Sapienza", 00189 
      Rome, Italy.
FAU - Maugliani, Elisa
AU  - Maugliani E
AD  - Department of Neurosciences, Mental Health and Sense Organs (NESMOS), 
      Ophthalmology Unit, St. Andrea Hospital, University of Rome "La Sapienza", 00189 
      Rome, Italy.
FAU - Abdolrahimzadeh, Solmaz
AU  - Abdolrahimzadeh S
AUID- ORCID: 0000-0003-0920-8732
AD  - Department of Sense Organs, University Sapienza of Rome, 00161 Rome, Italy.
LA  - eng
GR  - AR22117A81528669/Sapienza University of Rome/
PT  - Journal Article
PT  - Review
DEP - 20221009
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Aging/physiology
MH  - Bruch Membrane
MH  - *Choroid/metabolism
MH  - Humans
MH  - *Macular Degeneration/metabolism
PMC - PMC9570412
OTO - NOTNLM
OT  - age-related macular degeneration
OT  - aging
OT  - choroid
OT  - choroidal vascularity index
OT  - retina
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/18 06:00
PMCR- 2022/10/09
CRDT- 2022/10/14 02:14
PHST- 2022/07/20 00:00 [received]
PHST- 2022/08/26 00:00 [revised]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2022/10/14 02:14 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/18 06:00 [medline]
PHST- 2022/10/09 00:00 [pmc-release]
AID - ijms231912010 [pii]
AID - ijms-23-12010 [pii]
AID - 10.3390/ijms231912010 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Oct 9;23(19):12010. doi: 10.3390/ijms231912010.