PMID- 36233564
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221019
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 19
DP  - 2022 Sep 26
TI  - Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of 
      Cytokines in Migraine with and without Aura.
LID - 10.3390/jcm11195696 [doi]
LID - 5696
AB  - The aim of the study was to clarify correlations between body mass index (BMI), 
      blood pressure (BP), and serum levels of cytokines in female migraine patients. A 
      total of 14 migraineurs with aura, and 12 without aura during their interictal 
      period were compared with 25 controls. Interleukin-8 (IL-8), soluble 
      intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion 
      molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), interferon gamma 
      (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor 
      alpha (TGF-alpha), and plasminogen activator inhibitor-1 (PAI-1) were measured. 
      Migraineurs have elevated levels of IL-8, but decreased serum levels of PAI-1 and 
      sICAM-1 during the interictal period, regardless of aura. BMI correlates with BP, 
      and also with IFN-gamma and MMP-9 only in patients with aura. There are three 
      correlations in migraine patients with aura that are absent in patients without 
      aura: between IL-8 and PAI-1; MMP-9 and IL-8; and IL-8 and sICAM-1. Migraineurs 
      without aura, on the other hand, have correlations that patients with aura do not 
      have (between PAI-1 and MCP-1, sICAM-1; between MMP-9 and sICAM-1, MCP-1; between 
      TGF-alpha and PAI-1, MMP-9, sICAM-1; between sICAM-1 and MMP-9, PAI-1, MCP-1; as well 
      as between sVCAM-1 and MCP-1). PAI-1, TGF, and MMP-9 could be used as biomarkers 
      to distinguish migraineurs from healthy individuals.
FAU - Plinta, Aelita
AU  - Plinta A
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
FAU - Tretjakovs, Peteris
AU  - Tretjakovs P
AUID- ORCID: 0000-0001-9446-0558
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
FAU - Svirskis, Simons
AU  - Svirskis S
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
FAU - Logina, Inara
AU  - Logina I
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
FAU - Gersone, Gita
AU  - Gersone G
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
FAU - Jurka, Antra
AU  - Jurka A
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
FAU - Mikelsone, Indra
AU  - Mikelsone I
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
FAU - Blumfelds, Leons
AU  - Blumfelds L
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
FAU - Mackevics, Vitolds
AU  - Mackevics V
AUID- ORCID: 0000-0002-9991-2768
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
FAU - Bahs, Guntis
AU  - Bahs G
AD  - Faculty of Medicine, Riga Stradins University, 16 Dzirciema Str., LV-1007 Riga, 
      Latvia.
LA  - eng
PT  - Journal Article
DEP - 20220926
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9572946
OTO - NOTNLM
OT  - aura
OT  - blood pressure
OT  - body mass index
OT  - cytokines
OT  - migraine
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/15 06:01
PMCR- 2022/09/26
CRDT- 2022/10/14 02:16
PHST- 2022/08/20 00:00 [received]
PHST- 2022/09/19 00:00 [revised]
PHST- 2022/09/22 00:00 [accepted]
PHST- 2022/10/14 02:16 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/15 06:01 [medline]
PHST- 2022/09/26 00:00 [pmc-release]
AID - jcm11195696 [pii]
AID - jcm-11-05696 [pii]
AID - 10.3390/jcm11195696 [doi]
PST - epublish
SO  - J Clin Med. 2022 Sep 26;11(19):5696. doi: 10.3390/jcm11195696.