PMID- 36233781
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221019
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 19
DP  - 2022 Oct 7
TI  - Association Study of the SLC1A2 (rs4354668), SLC6A9 (rs2486001), and SLC6A5 
      (rs2000959) Polymorphisms in Major Depressive Disorder.
LID - 10.3390/jcm11195914 [doi]
LID - 5914
AB  - The membrane excitatory amino acid transporter 2 (EAAT2), encoded by SLC1A2, is 
      responsible for the uptake and redistribution of synaptic glutamate. Glycine 
      modulates excitatory neurotransmission. The clearance of synaptic glycine is 
      performed by glycine transporters encoded by SLC6A9 and SLC6A5. Higher synaptic 
      glycine and glutamate levels could enhance the activation of NMDA receptors and 
      counteract the hypofunction of glutamate neurotransmission described in major 
      depressive disorder (MDD). The aim of the study was to assess whether 
      polymorphisms of SCL1A2 (rs4354668), SCL6A5 (rs2000959), and SCL6A9 (rs2486001) 
      play a role in the development of MDD and its clinical picture in the Polish 
      population. The study group consisted of 161 unrelated Caucasian patients with 
      MDD and 462 healthy unrelated individuals for control. Polymorphisms were 
      genotyped with PCR-RLFP assay. We observed that the frequency of genotype CC and 
      allele C of the SLC1A2 polymorphism rs4354668 was twice as high in the MDD group 
      as in control. Such differences were not detected in SLC6A5 and SLC6A9 
      polymorphisms. No statistically significant association of the studied SNPs 
      (Single Nucleotide Polymorphisms) on clinical variables of the MDD was observed. 
      The current study indicates an association of polymorphism rs4354668 in SCL1A2 
      with depression occurrence in the Polish population; however, further studies 
      with larger samples should be performed to clarify these findings.
FAU - Rodek, Patryk
AU  - Rodek P
AUID- ORCID: 0000-0003-1800-6745
AD  - Department and Clinic of Adult Psychiatry, Faculty of Medical Sciences, Medical 
      University of Silesia, Ziolowa 45, 40-635 Katowice, Poland.
FAU - Kowalczyk, Malgorzata
AU  - Kowalczyk M
AD  - Department of Medical Genetics, Faculty of Pharmaceutical Sciences, Medical 
      University of Silesia, Jednosci 8, 41-200 Sosnowiec, Poland.
FAU - Kowalski, Jan
AU  - Kowalski J
AD  - Department of Medical Genetics, Faculty of Pharmaceutical Sciences, Medical 
      University of Silesia, Jednosci 8, 41-200 Sosnowiec, Poland.
FAU - Owczarek, Aleksander
AU  - Owczarek A
AUID- ORCID: 0000-0003-1179-6932
AD  - Health Promotion and Obesity Management Unit, Department of Pathophysiology, 
      Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 
      15, 40-752 Katowice, Poland.
FAU - Choreza, Piotr
AU  - Choreza P
AD  - Department of Statistics, Faculty of Pharmaceutical Sciences in Sosnowiec, 
      Medical University of Silesia, 41-200 Katowice, Poland.
FAU - Kucia, Krzysztof
AU  - Kucia K
AUID- ORCID: 0000-0001-5618-2833
AD  - Department and Clinic of Adult Psychiatry, Faculty of Medical Sciences, Medical 
      University of Silesia, Ziolowa 45, 40-635 Katowice, Poland.
LA  - eng
GR  - KNW-1-019/N/5/0/Medical University of Silesia/
PT  - Journal Article
DEP - 20221007
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9571074
OTO - NOTNLM
OT  - MDD
OT  - depression
OT  - excitatory amino acid transporter 2
OT  - glutamate system
OT  - glycine transporter 1
OT  - glycine transporter 2
OT  - polymorphism
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/15 06:01
PMCR- 2022/10/07
CRDT- 2022/10/14 02:18
PHST- 2022/06/30 00:00 [received]
PHST- 2022/08/15 00:00 [revised]
PHST- 2022/10/04 00:00 [accepted]
PHST- 2022/10/14 02:18 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/15 06:01 [medline]
PHST- 2022/10/07 00:00 [pmc-release]
AID - jcm11195914 [pii]
AID - jcm-11-05914 [pii]
AID - 10.3390/jcm11195914 [doi]
PST - epublish
SO  - J Clin Med. 2022 Oct 7;11(19):5914. doi: 10.3390/jcm11195914.