PMID- 36235617
OWN - NLM
STAT- MEDLINE
DCOM- 20221017
LR  - 20221019
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 19
DP  - 2022 Sep 24
TI  - Trimethylamine N-Oxide (TMAO) and Indoxyl Sulfate Concentrations in Patients with 
      Alcohol Use Disorder.
LID - 10.3390/nu14193964 [doi]
LID - 3964
AB  - BACKGROUND: Trimethylamine N-oxide (TMAO) and indoxyl sulfate (IS) are produced 
      by the microbiota and the liver, and can contribute to brain aging and impaired 
      cognitive function. This study aims to examine serum TMAO and IS concentrations 
      in patients with alcohol-use disorder (AUD) at the entry for alcohol withdrawal, 
      and the relationships with several biological, neuropsychological, and clinical 
      parameters. METHODS: TMAO and IS were quantified in thirty AUD inpatients and 
      fifteen healthy controls (HC). The severities of AUD and alcohol withdrawal 
      syndrome (AWS), and general cognitive abilities were assessed in AUD patients. 
      RESULTS: TMAO concentrations did not differ between HC and AUD patients. Several 
      biomarkers assessing nutritional status and liver function were significantly 
      different in AUD patients with the lowest TMAO concentrations compared to other 
      AUD patients. IS concentration was significantly lower in AUD patients and a 
      significant positive predictor of serum prealbumin variation during the acute 
      phase of alcohol withdrawal. No relationship was observed between the 
      concentrations of these metabolites and the severities of alcohol dependence, 
      AWS, or cognitive deficits. CONCLUSIONS: Our data suggest that AUD patients with 
      low concentrations of TMAO or IS should probably benefit from a personalized 
      refeeding program during the acute phase of alcohol withdrawal.
FAU - Coulbault, Laurent
AU  - Coulbault L
AD  - Physiopathology and Imaging of Neurological Disorder (PhIND), Cyceron, Institut 
      National de la Sante et de la Recherche Biomedicale (INSERM), Institut Blood and 
      Brain @ Caen Normandie, Normandie University, Universite de Caen (UNICAEN), 14000 
      Caen, France.
AD  - Biochemistry Department, Caen University Hospital, 14000 Caen, France.
FAU - Laniepce, Alice
AU  - Laniepce A
AUID- ORCID: 0000-0001-5421-7182
AD  - Centre de Recherche sur les Fonctionnements et Dysfonctionnements psychologiques 
      (CRFDP, EA7475), Normandie University, Universite de Rouen (UNIROUEN), 76000 
      Rouen, France.
FAU - Segobin, Shailendra
AU  - Segobin S
AD  - Physiopathology and Imaging of Neurological Disorder (PhIND), Cyceron, Institut 
      National de la Sante et de la Recherche Biomedicale (INSERM), Institut Blood and 
      Brain @ Caen Normandie, Normandie University, Universite de Caen (UNICAEN), 14000 
      Caen, France.
FAU - Boudehent, Celine
AU  - Boudehent C
AD  - Addictology Department, Caen University Hospital, 14000 Caen, France.
FAU - Cabe, Nicolas
AU  - Cabe N
AUID- ORCID: 0000-0002-8051-0742
AD  - Physiopathology and Imaging of Neurological Disorder (PhIND), Cyceron, Institut 
      National de la Sante et de la Recherche Biomedicale (INSERM), Institut Blood and 
      Brain @ Caen Normandie, Normandie University, Universite de Caen (UNICAEN), 14000 
      Caen, France.
AD  - Addictology Department, Caen University Hospital, 14000 Caen, France.
FAU - Pitel, Anne Lise
AU  - Pitel AL
AD  - Physiopathology and Imaging of Neurological Disorder (PhIND), Cyceron, Institut 
      National de la Sante et de la Recherche Biomedicale (INSERM), Institut Blood and 
      Brain @ Caen Normandie, Normandie University, Universite de Caen (UNICAEN), 14000 
      Caen, France.
LA  - eng
GR  - RPV10004EEA/Agence Nationale pour la Recherche/
GR  - RPH10015EEA/Conseil Regional de Basse-Normandie/
GR  - RPE10001EEA/Mission Interministerielle de Lutte contre les Drogues et les 
      Conduites Addictives/
PT  - Journal Article
DEP - 20220924
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Methylamines)
RN  - 0 (Prealbumin)
RN  - FLD0K1SJ1A (trimethyloxamine)
RN  - N187WK1Y1J (Indican)
SB  - IM
MH  - *Alcoholism
MH  - Biomarkers
MH  - Humans
MH  - Indican
MH  - Methylamines
MH  - Prealbumin
MH  - *Substance Withdrawal Syndrome
PMC - PMC9572718
OTO - NOTNLM
OT  - alcohol
OT  - alcohol used disorder
OT  - cognition
OT  - indoxyl sulfate
OT  - liver
OT  - trimethylamine N-oxide
COIS- The authors declare no conflict of interest.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/18 06:00
PMCR- 2022/09/24
CRDT- 2022/10/14 02:31
PHST- 2022/08/10 00:00 [received]
PHST- 2022/09/14 00:00 [revised]
PHST- 2022/09/21 00:00 [accepted]
PHST- 2022/10/14 02:31 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/18 06:00 [medline]
PHST- 2022/09/24 00:00 [pmc-release]
AID - nu14193964 [pii]
AID - nutrients-14-03964 [pii]
AID - 10.3390/nu14193964 [doi]
PST - epublish
SO  - Nutrients. 2022 Sep 24;14(19):3964. doi: 10.3390/nu14193964.