PMID- 36237763
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221015
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 9
DP  - 2022 Sep
TI  - An Unusual Association Between Metformin and Nightmares: A Case Report.
PG  - e28974
LID - 10.7759/cureus.28974 [doi]
LID - e28974
AB  - Metformin remains the oral drug of choice for patients with type 2 diabetes 
      mellitus (T2DM). It is an ideal anti-diabetic drug for maintaining good glycemic 
      control in diabetics. However, the side effect profile of metformin varies from 
      minor or no effects to substantial impact on the GI tract. In addition, metformin 
      is rarely known for its association with nightmares. Here we present the case of 
      a newly diagnosed 40-year-old diabetic who developed recurrent nightmares within 
      a week of starting metformin treatment. The patient had no previous history of 
      psychiatric or sleep disorders. However, it was the first time he had experienced 
      such recurrent nightmares, especially after the start of 500 mg metformin thrice 
      a day. Based on the Naranjo Adverse Drug Reaction (ADR) Probability Scale, and 
      sudden onset and disappearance of nightmares after metformin initiation and 
      discontinuation made metformin the primary cause of his nightmares.
CI  - Copyright (c) 2022, Voloshyna et al.
FAU - Voloshyna, Diana
AU  - Voloshyna D
AD  - School of Medicine, University of Michigan, Ann Arbor, USA.
FAU - Sandhu, Qudsia I
AU  - Sandhu QI
AD  - Medicine, Ghazi Khan Medical College, Dera Ghazi Khan, PAK.
FAU - Khan, Saima
AU  - Khan S
AD  - Internal Medicine, Sir Syed College of Medical Sciences for Girls, Clifton, PAK.
FAU - Bseiso, Anan
AU  - Bseiso A
AD  - College of Medicine, Al-Quds University, Jerusalem, PSE.
FAU - Mengar, Jaina
AU  - Mengar J
AD  - Medicine and Surgery, Government Medical College and New Civil Hospital, Surat, 
      IND.
FAU - Nayudu, Nirupama
AU  - Nayudu N
AD  - Internal Medicine, Zhengzhou University, Zhengzhou, CHN.
FAU - Kumar, Rajesh
AU  - Kumar R
AD  - Medicine and Surgery, Jinnah Sindh Medical University, Karachi, PAK.
FAU - Khemani, Deepa
AU  - Khemani D
AD  - Medicine and Surgery, Jinnah Sindh Medical University, Karachi, PAK.
FAU - Usama, Muhammad
AU  - Usama M
AD  - Neurology, Sheikh Zayed Medical College, Rahim Yar Khan, Rahim Yar Khan, PAK.
LA  - eng
PT  - Case Reports
DEP - 20220909
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9548325
OTO - NOTNLM
OT  - abnormal dreams
OT  - bizzare and vivid dreams
OT  - diabetes
OT  - metformin
OT  - metformin side effects
OT  - nightmares
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/15 06:01
PMCR- 2022/09/09
CRDT- 2022/10/14 02:55
PHST- 2022/09/09 00:00 [accepted]
PHST- 2022/10/14 02:55 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/15 06:01 [medline]
PHST- 2022/09/09 00:00 [pmc-release]
AID - 10.7759/cureus.28974 [doi]
PST - epublish
SO  - Cureus. 2022 Sep 9;14(9):e28974. doi: 10.7759/cureus.28974. eCollection 2022 Sep.