PMID- 36237797
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221015
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 9
DP  - 2022 Sep
TI  - Role of Serum Homocysteine and Outcome in Patients With Traumatic Brain Injury.
PG  - e28968
LID - 10.7759/cureus.28968 [doi]
LID - e28968
AB  - Background There have been indications of a correlation between serum 
      homocysteine (Hcy) levels and poor patient outcomes in traumatic brain injury 
      (TBI). Thus, we aimed to explore the role of serum Hcy in influencing the outcome 
      post TBI. Methods A case-control study was conducted at Liaquat University of 
      Medical and Health Sciences (LUMHS) between January 15, 2022 and July 1, 2022. 
      All patients between the ages of 18 and 75 years who presented with TBI, 
      irrespective of severity, were included in the study. All patients with 
      neurological disorders and infections, including but not limited to cerebral 
      tuberculosis, Alzheimer's disease, epilepsy, brain cancer, Parkinson's, and 
      stroke, were excluded from the study. For comparison, healthy controls with 
      similar demographics were enrolled in the study. All patients and controls 
      underwent biochemical evaluation of serum Hcy and neurological assessment at 
      presentation. In addition, all sociodemographic and clinical parameters, 
      including the Glasgow Outcome Score (GOS), were collected in a predefined pro 
      forma. Results A total of 175 patients were included who had experienced TBIs, 
      along with an equal number of healthy controls. The most common etiology was road 
      traffic accidents in 82 (46.9%) patients. The mean Glasgow Coma Score (GCS) at 
      presentation was 5.78 +/- 1.72. The mean Hcy levels were 31.4 +/- 7.97 micromol/L in TBI 
      patients and 11.12 +/- 5.87 micromol/L in the control healthy patients (p=0.001). It 
      was found that the severity of hyperhomocysteinemia (HHcy) was significantly 
      related to the worst outcome possible, i.e., death (p=0.001). Conclusion The 
      study concluded that patients who had suffered from a TBI had significantly 
      higher serum Hcy levels. Furthermore, the study highlighted that the patients 
      with the worst outcomes had more severe hyperhomocysteinemia (HHcy) than those 
      with better outcomes. Moreover, patients with low GOS scores were more likely to 
      have HHcy.
CI  - Copyright (c) 2022, Amini et al.
FAU - Amini, Humayoun
AU  - Amini H
AD  - Cardiology, Liaquatian Academic and Research Society, Hyderabad, PAK.
FAU - Hewadmal, Hewad
AU  - Hewadmal H
AD  - Cardiology, Sheikh Zayed Hospital and Medical College, Rahim Yar Khan, PAK.
FAU - Rasuli, Sayed Farhad
AU  - Rasuli SF
AD  - Laparoscopic Surgery, Liaquatian Academic and Research Society, Hyderabad, PAK.
FAU - Shahriar, Chowdhury S
AU  - Shahriar CS
AD  - Internal Medicine, Liaquatian Academic and Research Society, Hyderabad, PAK.
FAU - Fattah, Abdul
AU  - Fattah A
AD  - Internal Medicine, Indus Medical College, Tando Muhammad Khan, PAK.
FAU - Kavanoor Sridhar, Hariharan
AU  - Kavanoor Sridhar H
AD  - Anaesthesiology, Liaquatian Academic and Research Society, Hyderabad, PAK.
FAU - Khan, Marjan
AU  - Khan M
AD  - Internal Medicine, Marshfield Clinic Health System, Marshfield, USA.
FAU - Bhat, Sadaf
AU  - Bhat S
AD  - Internal Medicine, Liaquat University of Medical and Health Sciences, Hyderabad, 
      PAK.
FAU - Talpur, Abdul Subhan
AU  - Talpur AS
AD  - Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, PAK.
FAU - Qadar, Laila Tul
AU  - Qadar LT
AD  - Internal Medicine, Dow University of Health Sciences, Karachi, PAK.
LA  - eng
PT  - Journal Article
DEP - 20220909
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9548089
OTO - NOTNLM
OT  - glasgow outcome score
OT  - homocysteine levels
OT  - hyperhomocysteinemia
OT  - road traffic injuries
OT  - traumatic brain injury
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/15 06:01
PMCR- 2022/09/09
CRDT- 2022/10/14 02:56
PHST- 2022/09/09 00:00 [accepted]
PHST- 2022/10/14 02:56 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/15 06:01 [medline]
PHST- 2022/09/09 00:00 [pmc-release]
AID - 10.7759/cureus.28968 [doi]
PST - epublish
SO  - Cureus. 2022 Sep 9;14(9):e28968. doi: 10.7759/cureus.28968. eCollection 2022 Sep.