PMID- 36238945
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221015
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 13
DP  - 2022
TI  - Meta-analysis of structural and functional brain abnormalities in schizophrenia 
      with persistent negative symptoms using activation likelihood estimation.
PG  - 957685
LID - 10.3389/fpsyt.2022.957685 [doi]
LID - 957685
AB  - BACKGROUND: Persistent negative symptoms (PNS) include both primary and secondary 
      negative symptoms that persist after adequate treatment, and represent an unmet 
      therapeutic need. Published magnetic resonance imaging (MRI) evidence of 
      structural and resting-state functional brain abnormalities in schizophrenia with 
      PNS has been inconsistent. Thus, the purpose of this meta-analysis is to identify 
      abnormalities in structural and functional brain regions in patients with PNS 
      compared to healthy controls. METHODS: We systematically searched PubMed, Web of 
      Science, and Embase for structural and functional imaging studies based on five 
      research methods, including voxel-based morphometry (VBM), diffusion tensor 
      imaging (DTI), functional connectivity (FC), the amplitude of low-frequency 
      fluctuation or fractional amplitude of low-frequency fluctuation (ALFF/fALFF), 
      and regional homogeneity (ReHo). Afterward, we conducted a coordinate-based 
      meta-analysis by using the activation likelihood estimation algorithm. RESULTS: 
      Twenty-five structural MRI studies and thirty-two functional MRI studies were 
      included in the meta-analyses. Our analysis revealed the presence of structural 
      alterations in patients with PNS in some brain regions including the bilateral 
      insula, medial frontal gyrus, anterior cingulate gyrus, left amygdala, superior 
      temporal gyrus, inferior frontal gyrus, cingulate gyrus and middle temporal 
      gyrus, as well as functional differences in some brain regions including the 
      bilateral precuneus, thalamus, left lentiform nucleus, posterior cingulate gyrus, 
      medial frontal gyrus, and superior frontal gyrus. CONCLUSION: Our study suggests 
      that structural brain abnormalities are consistently located in the prefrontal, 
      temporal, limbic and subcortical regions, and functional alterations are 
      concentrated in the thalamo-cortical circuits and the default mode network (DMN). 
      This study provides new insights for targeted treatment and intervention to delay 
      further progression of negative symptoms. SYSTEMATIC REVIEW REGISTRATION: 
      [https://www.crd.york.ac.uk/prospero/], identifier [CRD42022338669].
CI  - Copyright (c) 2022 Zhu, Wang, Zhou, Fang, Huang, Xie, Ge, Yan, Zhang and Chen.
FAU - Zhu, Tingting
AU  - Zhu T
AD  - Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Wang, Zixu
AU  - Wang Z
AD  - Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Zhou, Chao
AU  - Zhou C
AD  - Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Fang, Xinyu
AU  - Fang X
AD  - Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Huang, Chengbing
AU  - Huang C
AD  - Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - Department of Psychiatry, The Third People's Hospital of Huai'an, Huaian, China.
FAU - Xie, Chunming
AU  - Xie C
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine 
      Southeast University, Nanjing, China.
FAU - Ge, Honglin
AU  - Ge H
AD  - Institute of Neuropsychiatry, The Affiliated Brain Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Yan, Zheng
AU  - Yan Z
AD  - Institute of Neuropsychiatry, The Affiliated Brain Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Zhang, Xiangrong
AU  - Zhang X
AD  - Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing 
      Medical University, Nanjing, China.
AD  - The Affiliated Xuzhou Oriental Hospital of Xuzhou Medical University, Xuzhou, 
      China.
FAU - Chen, Jiu
AU  - Chen J
AD  - Institute of Neuropsychiatry, The Affiliated Brain Hospital of Nanjing Medical 
      University, Nanjing, China.
LA  - eng
PT  - Systematic Review
DEP - 20220927
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC9552970
OTO - NOTNLM
OT  - functional MRI
OT  - meta-analysis
OT  - persistent negative symptoms
OT  - schizophrenia
OT  - structural MRI
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/15 06:01
PMCR- 2022/09/27
CRDT- 2022/10/14 03:14
PHST- 2022/05/31 00:00 [received]
PHST- 2022/09/05 00:00 [accepted]
PHST- 2022/10/14 03:14 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/15 06:01 [medline]
PHST- 2022/09/27 00:00 [pmc-release]
AID - 10.3389/fpsyt.2022.957685 [doi]
PST - epublish
SO  - Front Psychiatry. 2022 Sep 27;13:957685. doi: 10.3389/fpsyt.2022.957685. 
      eCollection 2022.