PMID- 36239783
OWN - NLM
STAT- MEDLINE
DCOM- 20230308
LR  - 20230308
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 280
IP  - 4
DP  - 2023 Apr
TI  - Transcutaneous electrical acupoint stimulation for suspected laryngopharyngeal 
      reflux disease.
PG  - 1815-1825
LID - 10.1007/s00405-022-07698-9 [doi]
AB  - PURPOSE: To determine the efficacy of transcutaneous electrical acupoint 
      stimulation (TEAS) combined with proton pump inhibitor (PPI) therapy on symptoms 
      and signs of patients with suspected laryngopharyngeal reflux disease (LPRD). 
      METHODS: This was a prospective randomized controlled study. Seventy patients 
      with reflux symptom index (RSI) > 13 and reflux finding score (RFS) > 7 were 
      recruited and received PPI alone (control group) or TEAS combined with PPI 
      (experimental group) for 12 weeks. Patients in the experimental group received 
      TEAS at Tiantu (RN22), Renying (ST9), and Neiguan (PC6) once a day, five times a 
      week. RSI, RFS, throat pain visual analog score (VAS), and LPR-health-related 
      quality-of-life (LPR-HRQL) scores were evaluated at baseline and after 4 and 
      12 weeks. RESULTS: The decreases in total RSI and RFS, along with several 
      subscores, were significantly higher in the experimental group than in the 
      control group after 12 weeks (P < 0.05). The throat pain VAS and LPR-HRQL scores 
      decreased significantly at 4 and 12 weeks after treatment in both groups, with 
      significant differences between the groups (P < 0.001). No severe adverse events 
      occurred, and the rates of adverse events were similar between the two groups. 
      CONCLUSION: Compared with PPI alone, TEAS combined with PPI showed a 
      significantly greater improvement in symptoms, signs, and quality of life in the 
      treatment of LPRD without increasing the occurrence of adverse effects. 
      Therefore, TEAS could serve as a useful and safe treatment method for LPRD. TRIAL 
      REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2100046755.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Shen, Hailong
AU  - Shen H
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui, 
      230000, People's Republic of China.
FAU - Han, Yanxun
AU  - Han Y
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui, 
      230000, People's Republic of China.
FAU - Yao, Changyu
AU  - Yao C
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui, 
      230000, People's Republic of China.
FAU - Tao, Ye
AU  - Tao Y
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui, 
      230000, People's Republic of China.
FAU - Wu, Jing
AU  - Wu J
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui, 
      230000, People's Republic of China.
FAU - Gao, Chaobing
AU  - Gao C
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui, 
      230000, People's Republic of China.
FAU - Wu, Feihu
AU  - Wu F
AD  - Department of Otolaryngology, The First Affiliated Hospital of Anhui University 
      of Chinese Medicine, Hefei, People's Republic of China.
FAU - Liu, Yehai
AU  - Liu Y
AUID- ORCID: 0000-0003-3977-2481
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital 
      of Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui, 
      230000, People's Republic of China. liuyehai@ahmu.edu.cn.
LA  - eng
GR  - AHWJ2021b160/the Scientific Research Project of the Anhui Provincial Health 
      Commission/
GR  - KJ2018ZD021/the 2018 University Scientific Research Project/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20221014
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
CIN - Eur Arch Otorhinolaryngol. 2022 Nov 11;:. PMID: 36357611
MH  - Humans
MH  - *Laryngopharyngeal Reflux/therapy/drug therapy
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Prospective Studies
MH  - Quality of Life
MH  - Acupuncture Points
OTO - NOTNLM
OT  - Laryngopharyngeal reflux disease
OT  - Proton pump inhibitor
OT  - Transcutaneous electrical acupoint stimulation
OT  - Treatment
EDAT- 2022/10/15 06:00
MHDA- 2023/03/09 06:00
CRDT- 2022/10/14 11:14
PHST- 2022/08/29 00:00 [received]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2023/03/09 06:00 [medline]
PHST- 2022/10/14 11:14 [entrez]
AID - 10.1007/s00405-022-07698-9 [pii]
AID - 10.1007/s00405-022-07698-9 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2023 Apr;280(4):1815-1825. doi: 
      10.1007/s00405-022-07698-9. Epub 2022 Oct 14.