PMID- 36240190
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20221019
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 10
DP  - 2022
TI  - Noninvasive evaluation of the hemodynamic status in patients after heart 
      transplantation or left ventricular assist device implantation.
PG  - e0275977
LID - 10.1371/journal.pone.0275977 [doi]
LID - e0275977
AB  - INTRODUCTION: Hemodynamic assessment is crucial after heart transplantation (HTX) 
      or left ventricular assist device (LVAD) implantation. Gold-standard is invasive 
      assessment via thermodilution (TD). Noninvasive pulse contour analysis (NPCA) is 
      a new technology that is supposed to determine hemodynamics completely 
      noninvasive. We aimed to validate this technology in HTX and LVAD patients and 
      conducted a prospective single-center cohort study. METHODS: Patients after HTX 
      or LVAD implantation underwent right heart catheterization including TD. NPCA 
      using the CNAP Monitor (V.5.2.14; CNSystems Medizintechnik AG, Graz, Austria) was 
      performed simultaneously. Three TD measurements were compared with simultaneous 
      NPCA measurements for hemodynamic assessment. To describe the agreement between 
      TD and NPCA, Bland-Altman analysis was done. RESULTS: In total, 28 patients were 
      prospectively enrolled (HTX: n = 10, LVAD: n = 18). Bland-Altman analysis 
      revealed a mean bias of +1.05 l/min (limits of agreement +/- 4.09 l/min, percentage 
      error 62.1%) for cardiac output (CO). In LVAD patients, no adequate NPCA signal 
      could be obtained. In 5 patients (27.8%), any NPCA signal could be detected, but 
      was considered as low signal quality. CONCLUSION: In conclusion, according to our 
      limited data in a small cohort of HTX and LVAD patients, NPCA using the CNAP 
      Monitor seems not to be suitable for noninvasive evaluation of the hemodynamic 
      status.
FAU - Roth, Sebastian
AU  - Roth S
AD  - Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, 
      Germany.
FAU - Fox, Henrik
AU  - Fox H
AUID- ORCID: 0000-0002-2187-8715
AD  - Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, 
      Ruhr Universitat Bochum, Bad Oeynhausen, Germany.
AD  - Heart Failure Department, Herz- und Diabeteszentrum NRW, Ruhr-Universitat Bochum, 
      Bad Oeynhausen, Germany.
FAU - M'Pembele, Rene
AU  - M'Pembele R
AD  - Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, 
      Germany.
FAU - Morshuis, Michiel
AU  - Morshuis M
AD  - Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, 
      Ruhr Universitat Bochum, Bad Oeynhausen, Germany.
AD  - Heart Failure Department, Herz- und Diabeteszentrum NRW, Ruhr-Universitat Bochum, 
      Bad Oeynhausen, Germany.
FAU - Lurati Buse, Giovanna
AU  - Lurati Buse G
AD  - Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, 
      Germany.
FAU - Hollmann, Markus W
AU  - Hollmann MW
AUID- ORCID: 0000-0001-8248-0244
AD  - Department of Anesthesiology, Amsterdam University Medical Center (AUMC), 
      Amsterdam, The Netherlands.
FAU - Huhn, Ragnar
AU  - Huhn R
AUID- ORCID: 0000-0002-3114-7190
AD  - Department of Anesthesiology, University Hospital Duesseldorf, Duesseldorf, 
      Germany.
AD  - Department of Anesthesiology, Kerckhoff Heart and Lung Center, Bad Nauheim, 
      Germany.
FAU - Bitter, Thomas
AU  - Bitter T
AD  - Department of Pneumology and Respiratory Medicine, Staedtisches Klinikum 
      Braunschweig, Braunschweig, Germany.
LA  - eng
PT  - Journal Article
DEP - 20221014
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Cohort Studies
MH  - *Heart Failure/surgery
MH  - *Heart Transplantation
MH  - *Heart-Assist Devices
MH  - Hemodynamics
MH  - Humans
MH  - Prospective Studies
PMC - PMC9565384
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/19 06:00
PMCR- 2022/10/14
CRDT- 2022/10/14 13:43
PHST- 2021/09/15 00:00 [received]
PHST- 2022/09/27 00:00 [accepted]
PHST- 2022/10/14 13:43 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/10/14 00:00 [pmc-release]
AID - PONE-D-21-29889 [pii]
AID - 10.1371/journal.pone.0275977 [doi]
PST - epublish
SO  - PLoS One. 2022 Oct 14;17(10):e0275977. doi: 10.1371/journal.pone.0275977. 
      eCollection 2022.