PMID- 36240634 OWN - NLM STAT- MEDLINE DCOM- 20221116 LR - 20230103 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 317 DP - 2022 Nov TI - Deep brain stimulation in obsessive-compulsive disorder: Results from meta-analysis. PG - 114869 LID - S0165-1781(22)00461-9 [pii] LID - 10.1016/j.psychres.2022.114869 [doi] AB - The aim of this work is to investigate the effectiveness of Deep Brain Stimulation (DBS) in patients with severe Obsessive Compulsive Disorder (OCD) who are resistant to pharmacological treatments, focusing on obsessive compulsive, depressive and anxiety symptoms as well as global function. A systematic review and meta-analysis including 25 studies (without language restrictions) from between 2003 and 2020 was performed. A total of 303 patients were evaluated twice (before and after DBS). After DBS treatment OCD patients with resistance to pharmacological treatments showed a significant improvement of obsessive-compulsive symptoms (25 studies; SMD=2.39; 95% CI, 1.91 to 2.87; P<0.0001), depression (9 studies; SMD= 1.19; 95%CI, 0.84 to 1.54; P<0.0001), anxiety (5 studies; SMD=1.00; 95%CI, 0.32 to 1.69; P=0.004) and functionality (7 studies; SMD=-3.51; 95%CI, -5.00 to -2.02; P=0.005) measured by the standardized scales: Yale Brown Obsessive Compulsive Scale (YBOCS), Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A) and Global Assessment of Function (GAF). Publication bias were discarded by using funnel plot. The main conclusions of this meta-analysis highlight the statistically significant effectiveness of DBS in patients with severe OCD who are resistant to conventional pharmacological treatments, underlying its role in global functioning apart from obsessive-compulsive symptoms. CI - Copyright (c) 2022. Published by Elsevier B.V. FAU - Cruz, Sheila AU - Cruz S AD - Child and Adolescent Mental Health Service, Jaen University Hospital Complex, Jaen, Spain. FAU - Gutierrez-Rojas, Luis AU - Gutierrez-Rojas L AD - Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Department of Psychiatry, University of Granada, Granada, Spain; Psychiatry Service, Hospital San Cecilio, Granada, Spain. Electronic address: gutierrezrojasl@hotmail.com. FAU - Gonzalez-Domenech, Pablo AU - Gonzalez-Domenech P AD - Department of Psychiatry, University of Granada, Granada, Spain. FAU - Diaz-Atienza, Francisco AU - Diaz-Atienza F AD - Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Department of Psychiatry, University of Granada, Granada, Spain; Child and Adolescent Mental Health Service, Granada Virgen de las Nieves University Hospital, Granada, Spain. FAU - Martinez-Ortega, Jose M AU - Martinez-Ortega JM AD - Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain; Department of Psychiatry, University of Granada, Granada, Spain. FAU - Jimenez-Fernandez, Sara AU - Jimenez-Fernandez S AD - Child and Adolescent Mental Health Service, Jaen University Hospital Complex, Jaen, Spain; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, Spain. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20220928 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Humans MH - *Deep Brain Stimulation/methods MH - *Obsessive-Compulsive Disorder/diagnosis MH - Anxiety MH - Treatment Outcome OTO - NOTNLM OT - Anxiety OT - Deep brain stimulation OT - Depression OT - Meta-analysis OT - Obsessive compulsive disorder COIS- Declaration of Competing Interest The researchers report no biomedical financial interests or potential conflicts of interests. EDAT- 2022/10/15 06:00 MHDA- 2022/11/18 06:00 CRDT- 2022/10/14 18:22 PHST- 2022/02/08 00:00 [received] PHST- 2022/09/25 00:00 [revised] PHST- 2022/09/26 00:00 [accepted] PHST- 2022/10/15 06:00 [pubmed] PHST- 2022/11/18 06:00 [medline] PHST- 2022/10/14 18:22 [entrez] AID - S0165-1781(22)00461-9 [pii] AID - 10.1016/j.psychres.2022.114869 [doi] PST - ppublish SO - Psychiatry Res. 2022 Nov;317:114869. doi: 10.1016/j.psychres.2022.114869. Epub 2022 Sep 28.