PMID- 36240684
OWN - NLM
STAT- MEDLINE
DCOM- 20221025
LR  - 20221025
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 16
IP  - 10
DP  - 2022 Oct
TI  - The efficacy of vitamin B(12) supplementation for treating vitamin B(12) 
      deficiency and peripheral neuropathy in metformin-treated type 2 diabetes 
      mellitus patients: A systematic review.
PG  - 102634
LID - S1871-4021(22)00248-X [pii]
LID - 10.1016/j.dsx.2022.102634 [doi]
AB  - BACKGROUND AND AIMS: Metformin-treated type 2 diabetes mellitus (T2DM) patients 
      are at higher risk of vitamin B(12) deficiency and more severe neuropathy 
      symptoms. There is still no guideline suggesting vitamin B(12) supplementation 
      for this population. This study aimed to analyze the efficacy of vitamin B(12) 
      supplementation in this population. METHOD: Studies reporting the efficacy of 
      vitamin B(12) supplementation in metformin-treated T2DM patients were 
      systematically searched in PubMed, Cochrane, EBSCOHost, and Scopus following the 
      Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 
      guideline. Additional relevant studies were searched manually through citations. 
      Study quality and risk of bias were assessed using suitable tools. RESULTS: Seven 
      clinical trials with a total of 506 participants were included. Using the 
      Cochrane's Risk of Bias 2 tools for clinical trials, 4 studies were assessed to 
      have high risk of bias and 3 studies had low risk of bias. There were 5 studies 
      that measured changes in serum vitamin B(12) level, all of which reported a 
      statistically significant increase after supplementation. Significant reductions 
      in homocysteine after supplementation were found in 2 studies. Its effect on 
      neuropathy symptoms was still unclear, with 2 studies reporting a significant 
      improvement and 1 study reporting no significant effect. CONCLUSIONS: The results 
      of this systematic review support the implementation of vitamin B(12) 
      supplementation for metformin-treated T2DM to prevent or treat vitamin B(12) 
      deficiency and neuropathy. More high-quality clinical studies are required to 
      generate quantitative analysis and to encourage supplementation in available 
      guidelines.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Pratama, Samuel
AU  - Pratama S
AD  - Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia. 
      Electronic address: samuel.pratama@gmail.com.
FAU - Lauren, Brigitta Cindy
AU  - Lauren BC
AD  - Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia.
FAU - Wisnu, Wismandari
AU  - Wisnu W
AD  - Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Division 
      of Endocrine, Metabolic and Diabetes, Internal Medicine Department, Dr. Cipto 
      Mangunkusumo Hospital, Jakarta, 10430, Indonesia.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20221002
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 9100L32L2N (Metformin)
RN  - P6YC3EG204 (Vitamin B 12)
RN  - 0 (Hypoglycemic Agents)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 0 (Vitamins)
SB  - IM
MH  - Humans
MH  - *Metformin/therapeutic use
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Vitamin B 12/therapeutic use
MH  - Hypoglycemic Agents/therapeutic use
MH  - *Vitamin B 12 Deficiency/drug therapy/etiology
MH  - *Peripheral Nervous System Diseases
MH  - Homocysteine
MH  - Dietary Supplements
MH  - Vitamins/therapeutic use
OTO - NOTNLM
OT  - (S): type 2 diabetes mellitus
OT  - Metformin
OT  - Peripheral neuropathy
OT  - Vitamin B(12) deficiency
OT  - Vitamin B(12) supplementation
COIS- Declaration of competing interest There is no conflict of interest regarding the 
      publication of this manuscript for all authors.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/26 06:00
CRDT- 2022/10/14 18:26
PHST- 2022/06/30 00:00 [received]
PHST- 2022/09/20 00:00 [revised]
PHST- 2022/09/25 00:00 [accepted]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/26 06:00 [medline]
PHST- 2022/10/14 18:26 [entrez]
AID - S1871-4021(22)00248-X [pii]
AID - 10.1016/j.dsx.2022.102634 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2022 Oct;16(10):102634. doi: 10.1016/j.dsx.2022.102634. 
      Epub 2022 Oct 2.