PMID- 36240893
OWN - NLM
STAT- MEDLINE
DCOM- 20221111
LR  - 20221111
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 222
IP  - Pt B
DP  - 2022 Dec 1
TI  - Skin-adaptive film dressing with smart-release of growth factors accelerated 
      diabetic wound healing.
PG  - 2729-2743
LID - S0141-8130(22)02295-4 [pii]
LID - 10.1016/j.ijbiomac.2022.10.054 [doi]
AB  - The general treatment of diabetic wound was use of wound dressings to absorb 
      excess exudate. However, traditional wound dressings neither mimic the skin-like 
      properties nor easily be withdrawn from the wound. Herein, the skin-adaptive 
      three-layered films (AGB) dressing has been designed by alternatively depositing 
      phenylboronic acid-grafted gamma-PGA (PBA-PGA) and polyvinyl alcohol (PVA). The 
      thickness of AGB film was only 479 mum and its flexibility was obviously 
      strengthen by the boronic ester cross-linking. Besides, the dry AGB film was 
      conveniently adhered to the fresh wound, where its adhesive force reached to 
      1267 +/- 330 mN. Moreover, the adhered AGB film was easily peeled without any 
      second damage after hydration. An anti-inflammatory tripeptide (KPV) and 
      epidermal growth factor (EGF) as biologic factors were respectively encapsulated 
      in the bottom layer and the middle-top two layers of AGB film. KPV was firstly 
      released within 3 day and EGF was subsequently released in a glucose-responsive 
      manner. AGB film containing KPV and EGF (K-E-AGB) could significantly improve the 
      repair rate of full-thickness skin wound on diabetic mice. The mechanism of wound 
      healing was associated with inflammatory inhibition, angiogenesis and collagen 
      deposition. Collectively, skin-adaptive film may be a promising dressing as 
      delivery of biologic factors for the chronic wound.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Zhao, Yingzheng
AU  - Zhao Y
AD  - Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325035, China. Electronic address: 
      pharmtds@163.com.
FAU - Huang, Lantian
AU  - Huang L
AD  - Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325035, China.
FAU - Lin, Gaolong
AU  - Lin G
AD  - Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325035, China.
FAU - Tong, Mengqi
AU  - Tong M
AD  - Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325035, China.
FAU - Xie, Yilin
AU  - Xie Y
AD  - Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325035, China.
FAU - Pan, Hanxiao
AU  - Pan H
AD  - Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325035, China.
FAU - Shangguan, Jianxun
AU  - Shangguan J
AD  - Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325035, China.
FAU - Yao, Qing
AU  - Yao Q
AD  - Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325035, China.
FAU - Xu, Shihao
AU  - Xu S
AD  - Department of Ultrasonography, the First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325000, China. Electronic address: 
      dcxshvip@163.com.
FAU - Xu, Helin
AU  - Xu H
AD  - Department of Pharmaceutics, School of Pharmaceutical Sciences, Wenzhou Medical 
      University, Wenzhou City, Zhejiang Province 325035, China. Electronic address: 
      xhlpharm1214@126.com.
LA  - eng
PT  - Journal Article
DEP - 20221012
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Epidermal Growth Factor/pharmacology
MH  - Wound Healing
MH  - *Diabetes Mellitus, Experimental/metabolism
MH  - Bandages
MH  - Collagen/chemistry
OTO - NOTNLM
OT  - Diabetic wound
OT  - Growth factors
OT  - Layer-by-layer film
EDAT- 2022/10/15 06:00
MHDA- 2022/11/15 06:00
CRDT- 2022/10/14 19:23
PHST- 2022/08/20 00:00 [received]
PHST- 2022/09/29 00:00 [revised]
PHST- 2022/10/06 00:00 [accepted]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/10/14 19:23 [entrez]
AID - S0141-8130(22)02295-4 [pii]
AID - 10.1016/j.ijbiomac.2022.10.054 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2022 Dec 1;222(Pt B):2729-2743. doi: 
      10.1016/j.ijbiomac.2022.10.054. Epub 2022 Oct 12.