PMID- 36241333
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20221018
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 298
DP  - 2022 Dec 15
TI  - The design of multi-responsive nanohydrogel networks of chitosan for controlled 
      drug delivery.
PG  - 120143
LID - S0144-8617(22)01048-7 [pii]
LID - 10.1016/j.carbpol.2022.120143 [doi]
AB  - High swelling hydrogel networks (HSHNs) are materials with the ability to high 
      swelling and outstanding candidates for sustained drug delivery systems (DDSs). 
      The present paper demonstrates three different chitosan nanohydrogel networks 
      (CNHN I-III) prepared through covalent and non-covalent interactions. These 
      hydrogels have a high swelling ratio (up to 38-fold their dry weight) in various 
      conditions. Two types of these hydrogels (CNHN I and II), swelled rapidly in an 
      acidic environment, were able to successfully load an extraordinary amount (up to 
      95 %) of a model drug doxorubicin hydrochloride (DOX.HCl) at a 1:1 ratio 
      (wt./wt.). The CNHN III had substantial swelling in pH 7.4, with a loading 
      capacity of 92 % 5-fluorouracil (5-FU) at a 1:1 ratio (wt./wt.). The CNHN I and 
      II have been considered for systemic drug delivery, while the CNHN III is one of 
      the best candidates for oral drug delivery.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Omrani, Mohsen
AU  - Omrani M
AD  - Research Laboratory of Green Organic Synthesis & Polymers, Department of 
      Chemistry, Iran University of Science and Technology, 16846-13114 Tehran, Iran.
FAU - Naimi-Jamal, M Reza
AU  - Naimi-Jamal MR
AD  - Research Laboratory of Green Organic Synthesis & Polymers, Department of 
      Chemistry, Iran University of Science and Technology, 16846-13114 Tehran, Iran. 
      Electronic address: naimi@iust.ac.ir.
FAU - Far, Bahareh Farasati
AU  - Far BF
AD  - Research Laboratory of Green Organic Synthesis & Polymers, Department of 
      Chemistry, Iran University of Science and Technology, 16846-13114 Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220923
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Drug Carriers)
RN  - 0 (Hydrogels)
RN  - 80168379AG (Doxorubicin)
RN  - 9012-76-4 (Chitosan)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - *Chitosan
MH  - Doxorubicin
MH  - Drug Carriers
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Fluorouracil
MH  - Hydrogels
MH  - Hydrogen-Ion Concentration
OTO - NOTNLM
OT  - Covalent and non-covalent interactions
OT  - Ionic H-bond
OT  - Multi-responsive nanohydrogel networks
OT  - Oral drug delivery
OT  - Systemic drug delivery
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/19 06:00
CRDT- 2022/10/14 21:04
PHST- 2022/05/07 00:00 [received]
PHST- 2022/09/17 00:00 [revised]
PHST- 2022/09/20 00:00 [accepted]
PHST- 2022/10/14 21:04 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
AID - S0144-8617(22)01048-7 [pii]
AID - 10.1016/j.carbpol.2022.120143 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2022 Dec 15;298:120143. doi: 10.1016/j.carbpol.2022.120143. Epub 
      2022 Sep 23.