PMID- 36242062
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221019
IS  - 2056-5909 (Print)
IS  - 2056-5909 (Electronic)
IS  - 2056-5909 (Linking)
VI  - 28
IP  - 1
DP  - 2022 Oct 15
TI  - Prediction of cardiovascular events by central blood pressure using radial 
      tonometry in type 2 diabetes mellitus patients.
PG  - 31
LID - 10.1186/s40885-022-00212-7 [doi]
LID - 31
AB  - BACKGROUND: High blood pressure (BP) and type 2 diabetes mellitus (T2DM) are 
      major causes of atherosclerotic cardiovascular disease (ASCVD) and heart failure 
      (HF). Central blood pressure (CBP) is more predictive of ASCVD than is brachial 
      BP; however, an association of CBP with ASCVD has not been found in T2DM 
      patients. We evaluated the impact of CBP and the association between optimal 
      level of noninvasively measured CBP and office BP in T2DM patients based on 
      composite outcome of ASCVD, HF, and complications of hypertension. METHODS: 
      Patients were enrolled from June 2011 to December 2015 and were followed up 
      through December 2019. CBP was measured using radial tonometry. The primary 
      endpoints were composite outcome of ASCVD, HF, and hypertension-induced 
      complications such as left ventricular hypertrophy, retinopathy, and proteinuria. 
      RESULTS: During the 6.5-year follow-up period, 515 patients were enrolled in the 
      study. A total of 92 patients (17.9%) developed primary endpoints. The mean age 
      of subjects was 61.3 +/- 12.1 years and 55% (n = 283) were male. Patients who 
      developed primary endpoints were older (65.3 +/- 9.5 years vs. 60.5 +/- 12.4 years) 
      and had lower high-density lipoprotein (36.6 +/- 9.4 mg/dL vs. 41.8 +/- 11.1 mg/dL), 
      higher CBP (123.6 +/- 20.6 mmHg vs. 118.0 +/- 20.6 mmHg), and higher pulse pressure 
      (61.3 +/- 16.6 mmHg vs. 56.5 +/- 15.1 mmHg) than subjects without primary endpoint 
      development. After adjustment for various risk factors, CBP was an independent 
      predictor for primary endpoints (hazard ratio, 1.14; 95% confidence interval, 
      1.02-1.27; P = 0.016). In addition, the association of CBP and primary endpoints 
      showed a U-shaped curve with the lowest incidence at CBP 118 mmHg and systolic BP 
      about 128 mmHg. CONCLUSIONS: We show the importance of CBP measurements in T2DM 
      patients and present a cutoff value for ASCVD events and hypertension-induced 
      complications.
CI  - (c) 2022. The Author(s).
FAU - Kim, Min-Sik
AU  - Kim MS
AUID- ORCID: 0000-0001-6434-2630
AD  - Division of Cardiology, Department of Internal Medicine, College of Medicine, St. 
      Vincent's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
FAU - Cha, Seon-Ah
AU  - Cha SA
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, 
      Seoul, Republic of Korea.
FAU - Kim, Gee-Hee
AU  - Kim GH
AUID- ORCID: 0000-0002-0279-7370
AD  - Division of Cardiology, Department of Internal Medicine, College of Medicine, St. 
      Vincent's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. 
      jiheekim@catholic.ac.kr.
AD  - College of Medicine, Catholic Research Institute for Intractable Cardiovascular 
      Disease, The Catholic University of Korea, Seoul, Republic of Korea. 
      jiheekim@catholic.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20221015
PL  - England
TA  - Clin Hypertens
JT  - Clinical hypertension
JID - 101669508
PMC - PMC9569105
OTO - NOTNLM
OT  - Atherosclerotic cardiovascular disease risk assessment
OT  - Central blood pressure
OT  - Hypertension
COIS- The authors declare that they have no competing interests.
EDAT- 2022/10/15 06:00
MHDA- 2022/10/15 06:01
PMCR- 2022/10/15
CRDT- 2022/10/14 23:50
PHST- 2021/12/13 00:00 [received]
PHST- 2022/06/07 00:00 [accepted]
PHST- 2022/10/14 23:50 [entrez]
PHST- 2022/10/15 06:00 [pubmed]
PHST- 2022/10/15 06:01 [medline]
PHST- 2022/10/15 00:00 [pmc-release]
AID - 10.1186/s40885-022-00212-7 [pii]
AID - 212 [pii]
AID - 10.1186/s40885-022-00212-7 [doi]
PST - epublish
SO  - Clin Hypertens. 2022 Oct 15;28(1):31. doi: 10.1186/s40885-022-00212-7.