PMID- 36243118
OWN - NLM
STAT- MEDLINE
DCOM- 20221114
LR  - 20221114
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 310
DP  - 2022 Dec 1
TI  - Polycystic ovary syndrome (PCOS) increases the risk of subsequent gestational 
      diabetes mellitus (GDM): A novel therapeutic perspective.
PG  - 121069
LID - S0024-3205(22)00769-X [pii]
LID - 10.1016/j.lfs.2022.121069 [doi]
AB  - Polycystic ovary syndrome (PCOS) is a multifactorial disorder that harms both the 
      reproductive as well as metabolic health of women. In addition, PCOS is a leading 
      symptom of infertility in women. Nevertheless, PCOS-afflicted women who are 
      fortunate enough to become pregnant unfortunately have an increased risk of 
      pregnancy complications, such as gestational diabetes mellitus (GDM), preterm 
      birth, etc. Many people believe GDM disappears after childbirth, despite the fact 
      that GDM is a warning symptom of type 2 diabetes mellitus (T2DM), metabolic 
      syndrome, and cardiovascular disease (CVD). According to growing evidence, GDM 
      complicates 40 % of PCOS pregnancies, suggesting that PCOS is a risk factor for 
      GDM. Hence, PCOS is a lifelong disorder that can eventually lead to various 
      long-term health complications, including chronic menstrual irregularity, 
      infertility, endometrial hyperplasia, and endometrial cancer. Thus, it's an 
      undeniable scientific fact that both PCOS and GDM are significantly associated 
      with each other. However, most studies on the risk of GDM in PCOS patients are 
      retrospective, hence inconclusive evidence exists as to whether PCOS per se is a 
      risk factor for GDM or any other factor associated. Henceforth, we intend to get 
      a better therapeutic perspective of the maternal health complications associated 
      with PCOS and GDM.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Choudhury, Abbas Alam
AU  - Choudhury AA
AD  - Department of Bio-Medical Sciences, School of Bio Sciences and Technology, 
      Vellore Institute of Technology, Vellore 632 014, Tamil Nadu, India. Electronic 
      address: abbas.choudhury@gmail.com.
FAU - Rajeswari, V Devi
AU  - Rajeswari VD
AD  - Department of Bio-Medical Sciences, School of Bio Sciences and Technology, 
      Vellore Institute of Technology, Vellore 632 014, Tamil Nadu, India. Electronic 
      address: vdevirajeswari@vit.ac.in.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221013
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
SB  - IM
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Humans
MH  - Female
MH  - *Diabetes, Gestational
MH  - *Polycystic Ovary Syndrome/complications
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Retrospective Studies
MH  - *Premature Birth
MH  - Risk Factors
MH  - *Infertility
OTO - NOTNLM
OT  - Diabetes
OT  - GDM
OT  - Infertility
OT  - Metabolic
OT  - PCOS
OT  - Reproductive
COIS- Declaration of competing interest The authors have declared that there is no 
      conflict of interest in publishing this article.
EDAT- 2022/10/16 06:00
MHDA- 2022/11/15 06:00
CRDT- 2022/10/15 19:33
PHST- 2022/09/06 00:00 [received]
PHST- 2022/10/03 00:00 [revised]
PHST- 2022/10/07 00:00 [accepted]
PHST- 2022/10/16 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/10/15 19:33 [entrez]
AID - S0024-3205(22)00769-X [pii]
AID - 10.1016/j.lfs.2022.121069 [doi]
PST - ppublish
SO  - Life Sci. 2022 Dec 1;310:121069. doi: 10.1016/j.lfs.2022.121069. Epub 2022 Oct 
      13.